CR immune protection?

[Guest guest]

Hi All,

Within the pdf-available below Medline abstract and brief full text excerpt

below,

CR is discussed regarding it protection of the immune system, it seems.

How CR compares with other immune loss intervention procedures may be

informative.

Salvador J, EJ, Ershler R, Ershler WB.

Future challenges in analysis and treatment of human immune senescence.

Immunol Allergy Clin North Am. 2003 Feb;23(1):133-48. Review.

PMID: 12645883

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=12645883 & query_hl=28

.... Numerous interventions have been used in an attempt to enhance immune

function

in old age (Table 1). Thymic hormones, other hormones, mediations, and cytokines

have been proposed as immunoenhancing agents, but none of these has gained

clinical

acceptance [83,84]. In animals, calorie restriction without undernutrition

clearly

prolongs life and is associated with immune competence into late life [85–88],

but

the benefits of calorie restriction in man remain unknown. Caloric restriction

studies in longer-lived species (eg, nonhuman primates [89,90]) have been

ongoing

for almost a decade; the National Institute on Aging has just initiated support

for

similar dietary intervention studies in humans [91].

Table 1 Methods of immune reconstitution

............................

Laboratory animals Clinical studies

.............................

Selective

Interleukin-2 FE NT

Vaccines FE FE

Intravenous immunoglobulin NT NT

Nutritional components (eg, Vitamin E, zinc) FE FE

Global

Organ transplantation (eg, thymus, spleen and bone marrow) FE NT

Caloric restriction FE, LE NT (trials underway)

Global nutritional supplementation FE, LE FE

Exercise FE FE

..............................

Abbreviations: FE, functional enhancement; LE, lifespan extending; NT, not

tested.

....

[85] Weindruch R, Walford RL.

Dietary restriction in mice beginning at 1 year of age.

Science 1982;215:1415–8.

[86] Masoro EJ.

Dietary restriction and aging.

J Am Geriatr Soc 1993;41:994–9.

[87] Weindruch R.

Caloric restriction and aging.

Sci Am 1996;274:46–52.

[88] Orr WC, Sohal RS.

Extension of life-span by overexpression of superoxide dismutase and catalase in

Drosophila melanogaster.

Science 1994;263(5150):1128–30.

[89] Roth GS, Ingram DK, Lane MA.

Caloric restriction in primates and relevance to humans.

Ann N Y Acad Sci 2001;928:305–15.

[90] Kemnitz JW, Weindruch R, Roecker EB, et al.

Dietary restriction of adult male rhesus monkeys: design, methodology, and

preliminary findings from the first year of study.

J Gerontol 1993;48(1):B17 26.

[91] Warner HR, Ingram D, RA, et al.

Program for testing biological interventions to promote healthy aging.

Mech Ageing Dev 2000;115:199–207.

Al Pater, PhD; email: old542000@...

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