Guest guest Posted September 29, 2005 Report Share Posted September 29, 2005 Hi All, How closely is the altered expression of genes affected by CR shown by its memetics? The results may impress. See the not pdf-available abstract of the paper below. Dhahbi JM, Mote PL, Fahy GM, Spindler SR. Identification of potential caloric restriction mimetics by microarray profiling. Physiol Genomics. 2005 Sep 27; [Epub ahead of print] PMID: 16189280 To facilitate the development of assays for the discovery of pharmaceuticals capable of mimicking the effects of caloric restriction on life- and healthspan (CR mimetics), we evaluated the effectiveness of glucoregulatory and putative cancer chemopreventatives in reproducing the hepatic gene-expression profile produced by long-term CR (LTCR) using Affymetrix microarrays. We have shown that CR initiated late in life begins to extend lifespan, reduce cancer as a cause of death, and reproduce ~three quarters of the genomic effects of LTCR in 8 weeks (CR8). Eight weeks of metformin treatment was superior to CR8 at reproducing LTCR-like gene expression changes, maintaining a superior number of such changes over a broad range of statistical stringencies, and producing more gene ontology terms overlapping those produced by LTCR. Consistent with these results, metformin has been shown to reduce cancer incidence in mice and humans. Phenformin, a chemical cousin of metformin, extends lifespan and reduces tumor incidence in mice. Taken together, these results indicate that gene-expression biomarkers can be used to identify promising candidate CR mimetics. Al Pater, PhD; email: old542000@... __________________________________ - PC Magazine Editors' Choice 2005 http://mail. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 29, 2005 Report Share Posted September 29, 2005 Hi Al: Of course we would all be delighted if we could take a supplement that would have the same effects on lifespan as CR. But given all the bad things that are being said about what body fat, just by way of its existence, does to cause all kinds of trouble, one wonders whether the mimetic would also have to reduce body fat ............ without restraint of food intake. That would seem to be a tall order if the -Benedict kind of analyses of the relationship between food intake a body weight are meaningful - I.E. that for any level of caloric intake sustained on average over a long period there is a corresponding equilibrium body weight AEE (all else equal). How can we eat as much as we want, take a CR mimetic supplement, and not have excessive body fat? If there's a way I'd sure like to know about it. Rodney. --- In , Al Pater <old542000@y...> wrote: > Hi All, > > How closely is the altered expression of genes affected by CR shown by its memetics? > The results may impress. > > See the not pdf-available abstract of the paper below. > > Dhahbi JM, Mote PL, Fahy GM, Spindler SR. > Identification of potential caloric restriction mimetics by microarray profiling. > Physiol Genomics. 2005 Sep 27; [Epub ahead of print] > PMID: 16189280 > > To facilitate the development of assays for the discovery of pharmaceuticals capable > of mimicking the effects of caloric restriction on life- and healthspan (CR > mimetics), we evaluated the effectiveness of glucoregulatory and putative cancer > chemopreventatives in reproducing the hepatic gene-expression profile produced by > long-term CR (LTCR) using Affymetrix microarrays. We have shown that CR initiated > late in life begins to extend lifespan, reduce cancer as a cause of death, and > reproduce ~three quarters of the genomic effects of LTCR in 8 weeks (CR8). Eight > weeks of metformin treatment was superior to CR8 at reproducing LTCR-like gene > expression changes, maintaining a superior number of such changes over a broad range > of statistical stringencies, and producing more gene ontology terms overlapping > those produced by LTCR. Consistent with these results, metformin has been shown to > reduce cancer incidence in mice and humans. Phenformin, a chemical cousin of > metformin, extends lifespan and reduces tumor incidence in mice. Taken together, > these results indicate that gene-expression biomarkers can be used to identify > promising candidate CR mimetics. > > Al Pater, PhD; email: old542000@y... > > > > __________________________________ > - PC Magazine Editors' Choice 2005 > http://mail. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 29, 2005 Report Share Posted September 29, 2005 Hi Al: Of course we would all be delighted if we could take a supplement that would have the same effects on lifespan as CR. But given all the bad things that are being said about what body fat, just by way of its existence, does to cause all kinds of trouble, one wonders whether the mimetic would also have to reduce body fat ............ without restraint of food intake. That would seem to be a tall order if the -Benedict kind of analyses of the relationship between food intake a body weight are meaningful - I.E. that for any level of caloric intake sustained on average over a long period there is a corresponding equilibrium body weight AEE (all else equal). How can we eat as much as we want, take a CR mimetic supplement, and not have excessive body fat? If there's a way I'd sure like to know about it. Rodney. --- In , Al Pater <old542000@y...> wrote: > Hi All, > > How closely is the altered expression of genes affected by CR shown by its memetics? > The results may impress. > > See the not pdf-available abstract of the paper below. > > Dhahbi JM, Mote PL, Fahy GM, Spindler SR. > Identification of potential caloric restriction mimetics by microarray profiling. > Physiol Genomics. 2005 Sep 27; [Epub ahead of print] > PMID: 16189280 > > To facilitate the development of assays for the discovery of pharmaceuticals capable > of mimicking the effects of caloric restriction on life- and healthspan (CR > mimetics), we evaluated the effectiveness of glucoregulatory and putative cancer > chemopreventatives in reproducing the hepatic gene-expression profile produced by > long-term CR (LTCR) using Affymetrix microarrays. We have shown that CR initiated > late in life begins to extend lifespan, reduce cancer as a cause of death, and > reproduce ~three quarters of the genomic effects of LTCR in 8 weeks (CR8). Eight > weeks of metformin treatment was superior to CR8 at reproducing LTCR-like gene > expression changes, maintaining a superior number of such changes over a broad range > of statistical stringencies, and producing more gene ontology terms overlapping > those produced by LTCR. Consistent with these results, metformin has been shown to > reduce cancer incidence in mice and humans. Phenformin, a chemical cousin of > metformin, extends lifespan and reduces tumor incidence in mice. Taken together, > these results indicate that gene-expression biomarkers can be used to identify > promising candidate CR mimetics. > > Al Pater, PhD; email: old542000@y... > > > > __________________________________ > - PC Magazine Editors' Choice 2005 > http://mail. Quote Link to comment Share on other sites More sharing options...
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