High-fat verus high carbohydrate CR

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Hi All,

See the not pdf-available below paper that seems to say that low- versus

high-carbohydrate diets affect the distribution of body composition. Is it

better to

have more body fat and body weight with the high-fat diet? Insulin sensitivity

being less with the high-carbohydrate diet seemed to suggest the diet might be

preferential.

McNeel RL, Mersmann HJ.

Low- and high-carbohydrate diets: body composition differences in rats.

Obes Res. 2005 Oct;13(10):1651-60.

PMID: 16286512

.... energy expenditure (EE) after isoenergetic, energy-restricted intake of

low-carbohydrate/high-fat/high-protein (LC) and

high-carbohydrate/low-fat/moderate-protein (HC) diets.

RESEARCH METHODS AND PROCEDURES: Ten-week old female Sprague-Dawley rats were

fed a

high-fat diet ad libitum for 8 weeks to induce weight gain and fat deposition.

Weight-matched rats were then assigned to isoenergetic LC (Atkins) and HC

(American

Dietary Association Exchange) diets for 10 weeks at 65% of ad libitum energy

intake.

RESULTS: There was no significant difference in the serum lipid profiles or

amount

of body weight lost between the HC and LC groups, whereas a higher insulin

sensitivity index (p < 0.01) resulted from the HC compared with the LC diet.

Compared with the post-restriction LC group, the HC group demonstrated (p <

0.05)

higher EE during active hours, lower mRNA levels for the lipogenic genes

peroxisome

proliferator-activated receptor gamma2, lipoprotein lipase, and, adipocyte fatty

acid binding protein, decreased adipocyte cell volume, and decreased fat mass.

DISCUSSION: Results indicated down-regulation of lipogenic genes, decreased fat

mass, and, therefore, improved body composition in the post-restriction HC

compared

with the LC group. The small mean differences between the two diet groups (p =

0.11)

in 24-hour EE over the 10 weeks of diet intervention would account for the

majority

of the lower mean body weights in the post-restriction HC group. These data

suggest

that macronutrient composition of the diet influences body composition and

indicate

a distinction between HC and LC diets.

Al Pater, PhD; email: old542000@...

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