Any More Input on Alternate Day Feeding?

[Guest guest]

Hi folks:

Alternate day feeding (ADF) may have a number of advantages over

seven-day-per-week CRON. For a start that is how many of the mouse

caloric restriction experiments were conducted. Given how much

longer the mice lived it doesn't seem likely that it could be harmful.

I am not on an ADF routine at the moment. But I might be motivated

to fast Monday, Wednesday and Friday if I had more input. So if you

are doing it, or have information about it, please post anything you

think might be helpful. TIA.

Rodney.

[Guest guest]

Hi folks:

Here is a very recent paper by Mattson et al. on the topic.

" Cardioprotection by intermittent fasting in rats.

Ahmet I, Wan R, Mattson MP, Lakatta EG, Talan M.

Laboratory of Cardiovascular Sciences, National Institute on Aging,

Intramural Research Program, National Institutes of Health,

Baltimore, MD, USA.

BACKGROUND: Intermittent fasting (IF), a dietary regimen in which

food is available only every other day, increases the life span and

reduces the incidence of age-associated diseases in rodents. We have

reported neuroprotective effects of IF against ischemic injury of the

brain. In this study, we examined the effects of IF on ischemic

injury of the heart in rats. METHODS AND RESULTS: After 3 months of

IF or regular every-day feeding (control) diets started in 2-month-

old rats, myocardial infarction (MI) was induced by coronary artery

ligation. Twenty-four hours after MI, its size in the IF group was 2-

fold smaller, the number of apoptotic myocytes in the area at risk

was 4-fold less, and the inflammatory response was significantly

reduced compared with the control diet group. Serial echocardiography

revealed that during 10 weeks after MI (with continuation of the IF

regimen), the left ventricular (LV) remodeling and MI expansion that

were observed in the control diet group were absent in the IF group.

In a subgroup of animals with similar MI size at 1 week after MI,

further observation revealed less remodeling, better LV function, and

no MI expansion in the IF group compared with the control group.

CONCLUSIONS: IF protects the heart from ischemic injury and

attenuates post-MI cardiac remodeling, likely via antiapoptotic and

antiinflammatory mechanisms. " PMID: 16275865

Rodney.

--- In , " Rodney " <perspect1111@y...>

wrote:

>

> Hi folks:

>

> Alternate day feeding (ADF) may have a number of advantages over

> seven-day-per-week CRON. For a start that is how many of the mouse

> caloric restriction experiments were conducted. Given how much

> longer the mice lived it doesn't seem likely that it could be

harmful.

>

> I am not on an ADF routine at the moment. But I might be motivated

> to fast Monday, Wednesday and Friday if I had more input. So if

you

> are doing it, or have information about it, please post anything

you

> think might be helpful. TIA.

>

> Rodney.

>

[Guest guest]

Hi folks:

Here is a very recent paper by Mattson et al. on the topic.

" Cardioprotection by intermittent fasting in rats.

Ahmet I, Wan R, Mattson MP, Lakatta EG, Talan M.

Laboratory of Cardiovascular Sciences, National Institute on Aging,

Intramural Research Program, National Institutes of Health,

Baltimore, MD, USA.

BACKGROUND: Intermittent fasting (IF), a dietary regimen in which

food is available only every other day, increases the life span and

reduces the incidence of age-associated diseases in rodents. We have

reported neuroprotective effects of IF against ischemic injury of the

brain. In this study, we examined the effects of IF on ischemic

injury of the heart in rats. METHODS AND RESULTS: After 3 months of

IF or regular every-day feeding (control) diets started in 2-month-

old rats, myocardial infarction (MI) was induced by coronary artery

ligation. Twenty-four hours after MI, its size in the IF group was 2-

fold smaller, the number of apoptotic myocytes in the area at risk

was 4-fold less, and the inflammatory response was significantly

reduced compared with the control diet group. Serial echocardiography

revealed that during 10 weeks after MI (with continuation of the IF

regimen), the left ventricular (LV) remodeling and MI expansion that

were observed in the control diet group were absent in the IF group.

In a subgroup of animals with similar MI size at 1 week after MI,

further observation revealed less remodeling, better LV function, and

no MI expansion in the IF group compared with the control group.

CONCLUSIONS: IF protects the heart from ischemic injury and

attenuates post-MI cardiac remodeling, likely via antiapoptotic and

antiinflammatory mechanisms. " PMID: 16275865

Rodney.

--- In , " Rodney " <perspect1111@y...>

wrote:

>

> Hi folks:

>

> Alternate day feeding (ADF) may have a number of advantages over

> seven-day-per-week CRON. For a start that is how many of the mouse

> caloric restriction experiments were conducted. Given how much

> longer the mice lived it doesn't seem likely that it could be

harmful.

>

> I am not on an ADF routine at the moment. But I might be motivated

> to fast Monday, Wednesday and Friday if I had more input. So if

you

> are doing it, or have information about it, please post anything

you

> think might be helpful. TIA.

>

> Rodney.

>