Positive yo-yo results

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Hi All,

The above was a bit of a blast of past in terms of difficulties accessing the

archives. However, it may be refreshing to at least some to reiterate the

possible

benefits of stressing the CR regime via ups and downs in CR and weight. It may

have

been that the moderate CR employed disallowed the full potential of

straightforward,

continuous CR. Maybe, the added stress of the yo-yo diet amplified the moderate

effect. The system used was rather unnatural and might reduce the lifespan of

the

mice.

The mouse mammary tumor virus was used only for expression of transforming

growth

factor-alpha.

The full text is available free to all at the below site.

Cleary MP, son MK, FC, Getzin SC, Grande JP, Maihle NJ.

Weight-cycling decreases incidence and increases latency of mammary tumors to a

greater extent than does chronic caloric restriction in mouse mammary tumor

virus-transforming growth factor-alpha female mice.

Cancer Epidemiol Biomarkers Prev. 2002 Sep;11(9):836-43.

PMID: 12223427

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=12223427 & query_hl=7

http://cebp.aacrjournals.org/cgi/content/full/11/9/836

Al Pater, PhD; email: old542000@...

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