Fish fats vs insulin resistance

[Guest guest]

Hi All,

Our library has not yet received this issue of J Nutr, but the abstract

suggested

that reducing the n-6/n-3 fatty acid ratio with healthy fish fat benefited

insulin

dynamics.

Dietary (n-3) Long Chain Polyunsaturated Fatty Acids Prevent Sucrose-Induced

Insulin

Resistance in Rats

Ghafoorunissa, Ahamed Ibrahim, Laxmi Rajkumar, and Vani Acharya

J. Nutr. 2005;135 2634-2638

This study was designed to determine the effect of substituting (n-3) long-chain

PUFAs (LCPUFAs) for linoleic acid and hence decreasing the (n-6):(n-3) fatty

acid

ratio on sucrose-induced insulin resistance in rats. Weanling male Wistar rats

were

fed casein-based diets containing 100 g/kg fat for 12 wk. Insulin resistance was

induced by replacing starch (ST) with sucrose (SU). The dietary fats were

formulated

with groundnut oil, palmolein, and fish oil to provide the following ratios of

(n-6):(n-3) fatty acids: 210 (ST-210, SU-210), 50 (SU-50), 10 (SU-10), and 5

(SU-5).

Compared with starch (ST-210), sucrose feeding (SU-210) significantly increased

the

plasma insulin and triglyceride concentrations and the plasma insulin area under

the

curve (AUC) in response to an oral glucose load. Adipocytes isolated from rats

fed

SU-210 had greater lipolytic rate, lower insulin stimulated glucose transport,

and

lower insulin-mediated antilipolysis than those from rats fed ST-210. Decreasing

the

dietary (n-6):(n-3) ratio in sucrose-fed rats (SU-10 and SU-5) normalized the

plasma

insulin concentration and the AUC of insulin after a glucose load. The

sucrose-induced increase in plasma triglyceride concentration was normalized in

rats

fed SU-50, SU-10 and SU-5. Further, sucrose-induced alterations in adipocyte

lipolysis and antilipolysis were partially reversed and glucose transport

improved

in rats fed diets SU-5 and SU-10. In diaphragm phospholipids, decreasing the

(n-6):(n-3) ratio in the diet increased the concentration of (n-3) LCPUFAs with

concomitant decreases in the concentration of (n-6) LCPUFAs. These results

suggest

that (n-3) LCPUFAs at a level of 2.6 g/kg diet [0.56% energy (n-3) LCPUFAs,

(n-6):(n-3) ratio = 10] may prevent sucrose-induced insulin resistance by

improving

peripheral insulin sensitivity.

Al Pater, PhD; email: old542000@...

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