Female kidney cancer less with alcohol

[Guest guest]

Hi All,

See the pdf-available not yet in Medline abstract for a paper showing that

female

kidney cancer is actually reduced with moderate alcohol intake, which is

contrary to

the general rule for cancers.

Alcohol consumption and risk of renal cell carcinoma: A prospective study of

Swedish

women

International Journal of Cancer Volume 117, Issue 5, (p 848-853)

Bahram Rashidkhani, Agneta Åkesson, Per Lindblad, Alicja Wolk

Published Online: 14 Jun 2005

Previous literature, although not consistent, suggests that moderate alcohol

consumption might be associated with decreased risk of renal cell carcinoma

(RCC) in

women. Thus, we examined the association between alcohol intake and the

incidence of

RCC by analyzing data from the Swedish Mammography Cohort, a population-based

prospective cohort of 59,237 women, aged 40-76 years, who, at baseline in

1987-1990,

were cancer free and had completed a food-frequency questionnaire including

questions about alcohol consumption. Through June 30, 2004, 132 incident cases

of

RCC were diagnosed. We used the proportional hazards model to estimate age

and

body mass index (BMI) adjusted rate ratios (RRs) and their 95% confidence

intervals

(CIs). Women who consumed >4.3 grams per day of alcohol (ethanol) had

nonsignificantly lower risk of RCC than did women who consumed <2.5 g/d (RR =

0.71,

95% CI 0.42-1.19); among women 55 years of age at entry into the cohort,

corresponding risk estimates were RR = 0.33, 95% CI 0.10-1.05, p for trend =

0.04

and among women with BMI >25 kg/m2, RR = 0.30, 95% CI 0.09-0.97, p for trend =

0.04.

Consistent with these findings, women who drank 1 or more servings of total

alcoholic beverages per week had lower RCC risk than did women who drank less

(RR =

0.62, 95% CI 0.41-0.94); the corresponding estimate for women 55 years of age

was RR

= 0.44, 95% CI 0.22-0.88. Results from our prospective cohort study of

middle-aged

and elderly women indicate that moderate alcohol consumption may be associated

with

decreased risk of RCC.

Al Pater, PhD; email: old542000@...

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