Spindler metformin /CR spins

[Guest guest]

Hi All,

See:

' " It looks almost exactly like calorie restriction in its effects, " said

Spindler with University of California-Riverside. " And so we're hopeful that

that

one drug might have similar effects on lifespan and on health. "

But they caution, it's not known how metformin would affect healthy people.

" I hope that healthy non-diabetic people won't begin buying metformin and taking

it, " Spindler said. " I think anytime you start experimenting on yourself that

you're

entering dangerous territory. " '

in:

http://www.komotv.com/healthwatch/story.asp?ID=39729

for the latest spins on metformin by Dr. S Spindler.

Al Pater, PhD; email: old542000@...

__________________________________

- PC Magazine Editors' Choice 2005

http://mail.

[Guest guest]

PS:

Hi All,

How closely is the altered expression of genes affected by CR shown by its

memetics?

The results may impress.

See the not pdf-available abstract of the paper below.

Dhahbi JM, Mote PL, Fahy GM, Spindler SR.

Identification of potential caloric restriction mimetics by microarray

profiling.

Physiol Genomics. 2005 Sep 27; [Epub ahead of print]

PMID: 16189280

To facilitate the development of assays for the discovery of pharmaceuticals

capable

of mimicking the effects of caloric restriction on life- and healthspan (CR

mimetics), we evaluated the effectiveness of glucoregulatory and putative cancer

chemopreventatives in reproducing the hepatic gene-expression profile produced

by

long-term CR (LTCR) using Affymetrix microarrays. We have shown that CR

initiated

late in life begins to extend lifespan, reduce cancer as a cause of death, and

reproduce ~three quarters of the genomic effects of LTCR in 8 weeks (CR8). Eight

weeks of metformin treatment was superior to CR8 at reproducing LTCR-like gene

expression changes, maintaining a superior number of such changes over a broad

range

of statistical stringencies, and producing more gene ontology terms overlapping

those produced by LTCR. Consistent with these results, metformin has been shown

to

reduce cancer incidence in mice and humans. Phenformin, a chemical cousin of

metformin, extends lifespan and reduces tumor incidence in mice. Taken together,

these results indicate that gene-expression biomarkers can be used to identify

promising candidate CR mimetics.

Al Pater, PhD; email: old542000@...

__________________________________

- PC Magazine Editors' Choice 2005

http://mail.

[Guest guest]

PS:

Hi All,

How closely is the altered expression of genes affected by CR shown by its

memetics?

The results may impress.

See the not pdf-available abstract of the paper below.

Dhahbi JM, Mote PL, Fahy GM, Spindler SR.

Identification of potential caloric restriction mimetics by microarray

profiling.

Physiol Genomics. 2005 Sep 27; [Epub ahead of print]

PMID: 16189280

To facilitate the development of assays for the discovery of pharmaceuticals

capable

of mimicking the effects of caloric restriction on life- and healthspan (CR

mimetics), we evaluated the effectiveness of glucoregulatory and putative cancer

chemopreventatives in reproducing the hepatic gene-expression profile produced

by

long-term CR (LTCR) using Affymetrix microarrays. We have shown that CR

initiated

late in life begins to extend lifespan, reduce cancer as a cause of death, and

reproduce ~three quarters of the genomic effects of LTCR in 8 weeks (CR8). Eight

weeks of metformin treatment was superior to CR8 at reproducing LTCR-like gene

expression changes, maintaining a superior number of such changes over a broad

range

of statistical stringencies, and producing more gene ontology terms overlapping

those produced by LTCR. Consistent with these results, metformin has been shown

to

reduce cancer incidence in mice and humans. Phenformin, a chemical cousin of

metformin, extends lifespan and reduces tumor incidence in mice. Taken together,

these results indicate that gene-expression biomarkers can be used to identify

promising candidate CR mimetics.

Al Pater, PhD; email: old542000@...

__________________________________

- PC Magazine Editors' Choice 2005

http://mail.

[Guest guest]

Too late on metformin. Some folks have been taking it and promoting it's anti-aging effects for years....to wit, Ward Dean, MD. See his metformin statement cirica 1998:

http://www.vrp.com/art/551.asp

On 10/14/05, Al Pater <old542000@...> wrote:

PS:Hi All,How closely is the altered expression of genes affected by CR shown by its memetics?

The results may impress.See the not pdf-available abstract of the paper below.Dhahbi JM, Mote PL, Fahy GM, Spindler SR.Identification of potential caloric restriction mimetics by microarray profiling.

Physiol Genomics. 2005 Sep 27; [Epub ahead of print]PMID: 16189280To facilitate the development of assays for the discovery of pharmaceuticals capableof mimicking the effects of caloric restriction on life- and healthspan (CR

mimetics), we evaluated the effectiveness of glucoregulatory and putative cancerchemopreventatives in reproducing the hepatic gene-expression profile produced bylong-term CR (LTCR) using Affymetrix microarrays. We have shown that CR initiated

late in life begins to extend lifespan, reduce cancer as a cause of death, andreproduce ~three quarters of the genomic effects of LTCR in 8 weeks (CR8). Eightweeks of metformin treatment was superior to CR8 at reproducing LTCR-like gene

expression changes, maintaining a superior number of such changes over a broad rangeof statistical stringencies, and producing more gene ontology terms overlappingthose produced by LTCR. Consistent with these results, metformin has been shown to

reduce cancer incidence in mice and humans. Phenformin, a chemical cousin ofmetformin, extends lifespan and reduces tumor incidence in mice. Taken together,these results indicate that gene-expression biomarkers can be used to identify

promising candidate CR mimetics.Al Pater, PhD; email: old542000@...__________________________________ - PC Magazine Editors' Choice 2005

http://mail.

[Guest guest]

Too late on metformin. Some folks have been taking it and promoting it's anti-aging effects for years....to wit, Ward Dean, MD. See his metformin statement cirica 1998:

http://www.vrp.com/art/551.asp

On 10/14/05, Al Pater <old542000@...> wrote:

PS:Hi All,How closely is the altered expression of genes affected by CR shown by its memetics?

The results may impress.See the not pdf-available abstract of the paper below.Dhahbi JM, Mote PL, Fahy GM, Spindler SR.Identification of potential caloric restriction mimetics by microarray profiling.

Physiol Genomics. 2005 Sep 27; [Epub ahead of print]PMID: 16189280To facilitate the development of assays for the discovery of pharmaceuticals capableof mimicking the effects of caloric restriction on life- and healthspan (CR

mimetics), we evaluated the effectiveness of glucoregulatory and putative cancerchemopreventatives in reproducing the hepatic gene-expression profile produced bylong-term CR (LTCR) using Affymetrix microarrays. We have shown that CR initiated

late in life begins to extend lifespan, reduce cancer as a cause of death, andreproduce ~three quarters of the genomic effects of LTCR in 8 weeks (CR8). Eightweeks of metformin treatment was superior to CR8 at reproducing LTCR-like gene

expression changes, maintaining a superior number of such changes over a broad rangeof statistical stringencies, and producing more gene ontology terms overlappingthose produced by LTCR. Consistent with these results, metformin has been shown to

reduce cancer incidence in mice and humans. Phenformin, a chemical cousin ofmetformin, extends lifespan and reduces tumor incidence in mice. Taken together,these results indicate that gene-expression biomarkers can be used to identify

promising candidate CR mimetics.Al Pater, PhD; email: old542000@...__________________________________ - PC Magazine Editors' Choice 2005

http://mail.