Fish oil and CR reduces inflammation markers 94%

[Guest guest]

Hi all,

Mouse study published in the journal Life Sciences shows

combined calorie-restriction and fish oil lowered inflammation

markers by as much as 94%.

" . . . . fish oil and/or a 40 per cent reduced food intake, ie.

calorie-restriction, effectively suppressed age-related inflammatory

process. . . . "

Regards,

Dave

link and full text:

http://www.nutraingredients.com/news/ng.asp?

n=67195 & m=1NIE420 & c=lqeudkujayvvlpc

More fish oil, fewer calories to reduce inflammation

20/04/2006- A low-calorie diet, rich in fish oil could reduce the

markers of inflammation by as much as 90 per cent, according to the

results of an animal study.

Chronic inflammation, brought about by an over-expression or lack of

control of the normal protective mechanism, can lead to a range of

inflammatory related disease, particularly cardiovascular disease.

The new study, published in the journal Life Sciences (Vol. 78, pp.

2523-2532), looked at the effects of fish oil and/or a calorie-

restricted diet on various markers of inflammation for old and young

female mice.

The diets were adopted when the mice were two months old and

formulated to contain either corn oil (5 per cent) or fish oil (5 per

cent containing DHA, EPA, palmitic acid), and the calorie-restriction

diets (60 per cent) were fed the same levels of fish or corn oil as

the controls.

At the end of the study the researchers measured various markers of

inflammation, such as levels of lipid oxidation, and concentrations

of reactive superoxide species, prostaglandins, and leukotriene B4,

for both the young mice (four months old) and old mice (nine months

old).

Mice eating the corn oil diet had superoxides levels about 18 per

cent higher than corn oil fed young mice. Young mice receiving the

fish oil-containing diet had superoxides levels almost 60 per cent

lower. Calorie-restricted young mice had a 35 per cent level of

superoxides, while young mice consuming the calorie-restricted fish

oil diet had levels 90 per cent lower than the young controls.

The effect of calorie-restriction and fish oil on superoxide

concentrations was also significant in the older mice. Both dietary

interventions reduced levels of reactive superoxide reduced by 94 per

cent.

Similar reductions were observed for both prostaglandin production

levels and the age-related production of leukotriene B4.

" The major findings of our present study are that dietary fish oil

and/or a 40 per cent reduced food intake, ie. calorie-restriction,

effectively suppressed age-related inflammatory process, " wrote the

authors, led by Hae Young Chung from Pusan National University, Korea.

" One other interesting finding is that fish oil feeding seems more

effective than calorie-restriction in its antioxidative and anti-

inflammatory effects, " they said.

The researchers also measured the expression of pro-inflammatory COX-

2 and iNOS on gene expression. Both were suppressed compared to the

corn oil, normal diet control mice.

The suppression of both COX-2 and iNOS reduced the expression of the

pro-inflammatory prostaglandin and leukotriene, both of which are

established mediators of inflammation.

The results of the study are in-line with previous research looking

at either calorie-restriction or omega-3 fatty acids on markers of

inflammation.

A study published recently in the Journal of the American College of

Cardiology (Vol. 47, Issue 2, pp. 398-402) reported that a calorie-

restricted diet could slow down heart aging and prolong the lifespan

of people. However, an accompanying editorial questioned whether the

majority of people would be able to adopt and sustain such a strict

diet.