High —> low PSA with prostate cancer

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Hi All,

The not pdf-available or in Medline yet below paper found that having a low

prostate

specific antigen does not mean the cancer all-clear for the prostate gland.

Prostate Cancer and Prostatic Diseases (2005) 8, 349–352.

doi:10.1038/sj.pcan.4500819; published online 12 July 2005

J L Boddy, D J Pike, S Al-Hayek, N Shaida and P R Malone

An elevated PSA, which normalizes, does not exclude the presence of prostate

cancer

Abstract

The purpose of this study was to determine the incidence of prostate cancer in

patients who have an elevated referral prostate-specific antigen (PSA), which

subsequently falls to within their normal age-specific reference range prior to

prostate biopsy. The study demonstrated that of the 160 patients recruited, 21

(13%)

had a repeat PSA level which had fallen back to within their normal range. Five

of

these 21 patients (24%) were diagnosed with prostate cancer following biopsy,

two of

whom had a benign prostate examination. The study, therefore, demonstrates that

normalisation of the PSA level prior to biopsy does not exclude the presence of

prostate cancer even when the prostate feels benign.

Al Pater, PhD; email: old542000@...

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