Re: Notice of Joint Bulk Purchase of >99% Resveratrol

[Guest guest]

Hi ,

I can't access the studies (I'd like to read them if possible, but it's

not critical).

Can you please tell me what the difference was between the two dosages?

Ten times the amount is a pretty big jump IMO.

TIA,

Dave

Antonik Wakfer wrote:

>

> Notice of Joint Bulk Purchase of >99% Resveratrol

>

> Participants are being sought for a joint bulk purchase of >99% pure

> fully synthetic trans-resveratrol from the exact same company (Orchid

> Chemicals and Pharmaceuticals Ltd of Chennai, India) that supplied the

> resveratrol used in the last two major published mouse feeding studies

> http://pmid.us/17086191 <http://pmid.us/17086191>

> http://pmid.us/17112576. <http://pmid.us/17112576.> In these studies

> trans-resveratrol, at human equivalent daily dosages of 5 and 50 mg/kg

> respectively, was shown to have major beneficial effects as a calorie

> restriction mimetic, and on enhanced mitochondrial activity resulting

> in more energy and stamina respectively. The pure synthetic has the

> advantage that it is completely free from plant contaminants which may

> have negative effects, while being exactly the same chemical as occurs

> in nature in red wine (among other sources). In order to obtain a

> supply of trans-resveratrol for myself and other interested parties, I

> am seeking others to join me in a large bulk purchase so that together

> we may get the far lower price per gram that the supplier will give

> for a large order. I have already successfully received and

> distributed to the initial joint purchase participants 4 kg from

> Orchid which is in the process of producing a large new batch to be

> ready by mid March 2007. This notice is for the purpose of increasing

> the amount that will be ordered at that time, if anyone should be

> interested.

>

> Here are the terms of this add-on commitment for new joint bulk

> purchase participants.

>

> Terms and Conditions of Joint Bulk Purchase as of Jan 18, 2007

>

> Pricing

>

> 100 grams @ $4.00 per gram,

> 200 grams @ $3.65 per gram,

> 300 grams @ $3.40 per gram,

> 400 grams @ $3.25 per gram,

> 500 grams @ $3.15 per gram.

>

> Packaging

>

> All purchases are packaged in 50 or 100 gm amounts in polypropylene

> (PP) zip-lock bags with all air expelled before the bag is closed. PP

> bags are much more moisture and air proof than are polyethylene (PE)

> bags (the standard that one gets at the supermarket). Each PP bag is

> placed in a zip-lock PE sandwich bag for added protection. Multiple

> bags are then placed into a bubble envelope which is then placed

> inside a USPS flat rate priority mail envelope for shipments of 200

> grams or less and a priority box for more than that. (For those

> outside the US things will be done a little differently as appropriate

> to your import needs.)

>

> Storage, handling and Dosage

>

> If the bags are kept in a freezer (all processes are slower at a lower

> temperature), and inside a light proof container (dark bottle or HDPE

> container), then research, reading and discussions with others

> suggests that there will be little degradation over a period of 2

> years. The mice researchers stated nothing about storage in nitrogen

> during the experiment and most of the storage time was in a

> refrigerator mixed with chow. During actual usage everyone would be

> wise to expel all air from the bag whenever it is reclosed after

> getting some out of it.

>

> When you remove some resveratrol from a larger package, only remove

> enough to last for, say, ten days or 2 weeks at a time and, when not

> in use, keep it in a small PP ziplock bag in a dark bottle in the

> refrigerator. Small PP zip-lock bags will be enclosed with every

> shipment package for the purpose of keeping this smaller in-use amount

> in the refrigerator.

>

> As for dosage, standard dosage increasing procedures for any new

> chemical suggests that it will be safest to start at 0.5 mg/kg daily

> and double every 2 weeks until you reach at least 5 mg/kg (which is

> what Dr Sinclair takes and what I am taking), but this is really

> a matter of individual choice and desire for experimentation. With

> respect to upper limits of dosage, note that there is no evidence of

> toxicity for resveratrol even at a human equivalent dosage of 75 mg/kg

> - http://pmid.us/15329443. <http://pmid.us/15329443.>

>

> Shipping and payment

>

> All prices include priority mail (USPS) shipping to US addresses and a

> copy of the Certificate of Analysis (COA) of the product.

> Insurance of package costs extra.

> Out of US shipping incurs a $25 surcharge (only $15 to Canada) with no

> customs entry guarantees.

> Email me your full legal name, physical and postal addresses, phone

> number and amount desired.

> Be prepared to pay in advance by check or money order in early March

> when the next order with Orchid will need to be placed and prepaid,

> since this is a joint bulk purchase and must be prepaid.

> I will email you when I need prepayment in March.

>

> Responsibility for Loss

>

> Everyone should be aware that although all joint purchasers received

> their allotted share of the first partial shipment, there is always

> some possibility that an entire future shipment, or merely a shipment

> to a particular joint purchaser, will be lost. Although as the

> coordinator of this prepaid joint bulk purchase I promise to do

> everything that I possibly can to prevent any such loss, I do not bear

> any responsibility for refunding any money in the case of any such loss.

>

> -- Wakfer

>

> MoreLife for the rational - http://morelife.org <http://morelife.org>

> Reality based tools for more life in quantity and quality

> The Self-Sovereign Individual Project - http://selfsip.org

> <http://selfsip.org>

> Rational freedom by self-sovereignty & social contracting

>

>

--

This is your brain on politics:

http://www.sciencedaily.com/releases/2006/01/060131092225.htm

Yep! You've been an annoying zombie all these years.

[Guest guest]

Hi Group:

This is the same bulk purchase that I announced to the group a short

time ago through . Some of you are already committed to part of

this next part of the purchase with me, as I have committed

already. I've read the studies, Dave and this is the same

Resveratrol used in them wherein impressive results were obtained.

.. At 07:51 PM 1/18/2007, you wrote:

>Hi ,

>

>I can't access the studies (I'd like to read them if possible, but it's

>not critical).

>

>Can you please tell me what the difference was between the two dosages?

>Ten times the amount is a pretty big jump IMO.

>

>TIA,

>

>Dave

>

> Antonik Wakfer wrote:

> >

> > Notice of Joint Bulk Purchase of >99% Resveratrol

> >

> > Participants are being sought for a joint bulk purchase of >99% pure

> > fully synthetic trans-resveratrol from the exact same company (Orchid

> > Chemicals and Pharmaceuticals Ltd of Chennai, India) that supplied the

> > resveratrol used in the last two major published mouse feeding studies

> > <http://pmid.us/17086191>http://pmid.us/17086191 <http://pmid.us/17086191>

> > <http://pmid.us/17112576.>http://pmid.us/17112576.

> <http://pmid.us/17112576.> In these studies

> > trans-resveratrol, at human equivalent daily dosages of 5 and 50 mg/kg

> > respectively, was shown to have major beneficial effects as a calorie

> > restriction mimetic, and on enhanced mitochondrial activity resulting

> > in more energy and stamina respectively. The pure synthetic has the

> > advantage that it is completely free from plant contaminants which may

> > have negative effects, while being exactly the same chemical as occurs

> > in nature in red wine (among other sources). In order to obtain a

> > supply of trans-resveratrol for myself and other interested parties, I

> > am seeking others to join me in a large bulk purchase so that together

> > we may get the far lower price per gram that the supplier will give

> > for a large order. I have already successfully received and

> > distributed to the initial joint purchase participants 4 kg from

> > Orchid which is in the process of producing a large new batch to be

> > ready by mid March 2007. This notice is for the purpose of increasing

> > the amount that will be ordered at that time, if anyone should be

> > interested.

> >

> > Here are the terms of this add-on commitment for new joint bulk

> > purchase participants.

> >

> > Terms and Conditions of Joint Bulk Purchase as of Jan 18, 2007

> >

> > Pricing

> >

> > 100 grams @ $4.00 per gram,

> > 200 grams @ $3.65 per gram,

> > 300 grams @ $3.40 per gram,

> > 400 grams @ $3.25 per gram,

> > 500 grams @ $3.15 per gram.

> >

> > Packaging

> >

> > All purchases are packaged in 50 or 100 gm amounts in polypropylene

> > (PP) zip-lock bags with all air expelled before the bag is closed. PP

> > bags are much more moisture and air proof than are polyethylene (PE)

> > bags (the standard that one gets at the supermarket). Each PP bag is

> > placed in a zip-lock PE sandwich bag for added protection. Multiple

> > bags are then placed into a bubble envelope which is then placed

> > inside a USPS flat rate priority mail envelope for shipments of 200

> > grams or less and a priority box for more than that. (For those

> > outside the US things will be done a little differently as appropriate

> > to your import needs.)

> >

> > Storage, handling and Dosage

> >

> > If the bags are kept in a freezer (all processes are slower at a lower

> > temperature), and inside a light proof container (dark bottle or HDPE

> > container), then research, reading and discussions with others

> > suggests that there will be little degradation over a period of 2

> > years. The mice researchers stated nothing about storage in nitrogen

> > during the experiment and most of the storage time was in a

> > refrigerator mixed with chow. During actual usage everyone would be

> > wise to expel all air from the bag whenever it is reclosed after

> > getting some out of it.

> >

> > When you remove some resveratrol from a larger package, only remove

> > enough to last for, say, ten days or 2 weeks at a time and, when not

> > in use, keep it in a small PP ziplock bag in a dark bottle in the

> > refrigerator. Small PP zip-lock bags will be enclosed with every

> > shipment package for the purpose of keeping this smaller in-use amount

> > in the refrigerator.

> >

> > As for dosage, standard dosage increasing procedures for any new

> > chemical suggests that it will be safest to start at 0.5 mg/kg daily

> > and double every 2 weeks until you reach at least 5 mg/kg (which is

> > what Dr Sinclair takes and what I am taking), but this is really

> > a matter of individual choice and desire for experimentation. With

> > respect to upper limits of dosage, note that there is no evidence of

> > toxicity for resveratrol even at a human equivalent dosage of 75 mg/kg

> > - <http://pmid.us/15329443.>http://pmid.us/15329443.

> <http://pmid.us/15329443.>

> >

> > Shipping and payment

> >

> > All prices include priority mail (USPS) shipping to US addresses and a

> > copy of the Certificate of Analysis (COA) of the product.

> > Insurance of package costs extra.

> > Out of US shipping incurs a $25 surcharge (only $15 to Canada) with no

> > customs entry guarantees.

> > Email me your full legal name, physical and postal addresses, phone

> > number and amount desired.

> > Be prepared to pay in advance by check or money order in early March

> > when the next order with Orchid will need to be placed and prepaid,

> > since this is a joint bulk purchase and must be prepaid.

> > I will email you when I need prepayment in March.

> >

> > Responsibility for Loss

> >

> > Everyone should be aware that although all joint purchasers received

> > their allotted share of the first partial shipment, there is always

> > some possibility that an entire future shipment, or merely a shipment

> > to a particular joint purchaser, will be lost. Although as the

> > coordinator of this prepaid joint bulk purchase I promise to do

> > everything that I possibly can to prevent any such loss, I do not bear

> > any responsibility for refunding any money in the case of any such loss.

> >

> > -- Wakfer

> >

> > MoreLife for the rational -

> <http://morelife.org>http://morelife.org <http://morelife.org>

> > Reality based tools for more life in quantity and quality

> > The Self-Sovereign Individual Project -

> <http://selfsip.org>http://selfsip.org

> > <http://selfsip.org>

> > Rational freedom by self-sovereignty & social contracting

> >

> >

>

>--

>This is your brain on politics:

>

><http://www.sciencedaily.com/releases/2006/01/060131092225.htm>http://www.scien\

cedaily.com/releases/2006/01/060131092225.htm

>

>Yep! You've been an annoying zombie all these years.

>

>

[Guest guest]

> >

> > Notice of Joint Bulk Purchase of >99% Resveratrol

> >

> > Participants are being sought for a joint bulk purchase of >99% pure

> > fully synthetic trans-resveratrol from the exact same company (Orchid

> > Chemicals and Pharmaceuticals Ltd of Chennai, India) that supplied the

> > resveratrol used in the last two major published mouse feeding studies

> > http://pmid.us/17086191 <http://pmid.us/17086191>

> > http://pmid.us/17112576. <http://pmid.us/17112576.> In these studies

> > trans-resveratrol, at human equivalent daily dosages of 5 and 50 mg/kg

> > respectively, was shown to have major beneficial effects as a calorie

> > restriction mimetic, and on enhanced mitochondrial activity resulting

> > in more energy and stamina respectively. The pure synthetic has the

> > advantage that it is completely free from plant contaminants which may

> > have negative effects, while being exactly the same chemical as occurs

> > in nature in red wine (among other sources). In order to obtain a

> > supply of trans-resveratrol for myself and other interested parties, I

> > am seeking others to join me in a large bulk purchase so that together

> > we may get the far lower price per gram that the supplier will give

> > for a large order. I have already successfully received and

> > distributed to the initial joint purchase participants 4 kg from

> > Orchid which is in the process of producing a large new batch to be

> > ready by mid March 2007. This notice is for the purpose of increasing

> > the amount that will be ordered at that time, if anyone should be

> > interested.

> >

> > Here are the terms of this add-on commitment for new joint bulk

> > purchase participants.

> >

> > Terms and Conditions of Joint Bulk Purchase as of Jan 18, 2007

> >

> > Pricing

> >

> > 100 grams @ $4.00 per gram,

> > 200 grams @ $3.65 per gram,

> > 300 grams @ $3.40 per gram,

> > 400 grams @ $3.25 per gram,

> > 500 grams @ $3.15 per gram.

> >

> > Packaging

> >

> > All purchases are packaged in 50 or 100 gm amounts in polypropylene

> > (PP) zip-lock bags with all air expelled before the bag is closed. PP

> > bags are much more moisture and air proof than are polyethylene (PE)

> > bags (the standard that one gets at the supermarket). Each PP bag is

> > placed in a zip-lock PE sandwich bag for added protection. Multiple

> > bags are then placed into a bubble envelope which is then placed

> > inside a USPS flat rate priority mail envelope for shipments of 200

> > grams or less and a priority box for more than that. (For those

> > outside the US things will be done a little differently as appropriate

> > to your import needs.)

> >

> > Storage, handling and Dosage

> >

> > If the bags are kept in a freezer (all processes are slower at a lower

> > temperature), and inside a light proof container (dark bottle or HDPE

> > container), then research, reading and discussions with others

> > suggests that there will be little degradation over a period of 2

> > years. The mice researchers stated nothing about storage in nitrogen

> > during the experiment and most of the storage time was in a

> > refrigerator mixed with chow. During actual usage everyone would be

> > wise to expel all air from the bag whenever it is reclosed after

> > getting some out of it.

> >

> > When you remove some resveratrol from a larger package, only remove

> > enough to last for, say, ten days or 2 weeks at a time and, when not

> > in use, keep it in a small PP ziplock bag in a dark bottle in the

> > refrigerator. Small PP zip-lock bags will be enclosed with every

> > shipment package for the purpose of keeping this smaller in-use amount

> > in the refrigerator.

> >

> > As for dosage, standard dosage increasing procedures for any new

> > chemical suggests that it will be safest to start at 0.5 mg/kg daily

> > and double every 2 weeks until you reach at least 5 mg/kg (which is

> > what Dr Sinclair takes and what I am taking), but this is really

> > a matter of individual choice and desire for experimentation. With

> > respect to upper limits of dosage, note that there is no evidence of

> > toxicity for resveratrol even at a human equivalent dosage of 75 mg/kg

> > - http://pmid.us/15329443. <http://pmid.us/15329443.>

> >

> > Shipping and payment

> >

> > All prices include priority mail (USPS) shipping to US addresses and a

> > copy of the Certificate of Analysis (COA) of the product.

> > Insurance of package costs extra.

> > Out of US shipping incurs a $25 surcharge (only $15 to Canada) with no

> > customs entry guarantees.

> > Email me your full legal name, physical and postal addresses, phone

> > number and amount desired.

> > Be prepared to pay in advance by check or money order in early March

> > when the next order with Orchid will need to be placed and prepaid,

> > since this is a joint bulk purchase and must be prepaid.

> > I will email you when I need prepayment in March.

> >

> > Responsibility for Loss

> >

> > Everyone should be aware that although all joint purchasers received

> > their allotted share of the first partial shipment, there is always

> > some possibility that an entire future shipment, or merely a shipment

> > to a particular joint purchaser, will be lost. Although as the

> > coordinator of this prepaid joint bulk purchase I promise to do

> > everything that I possibly can to prevent any such loss, I do not bear

> > any responsibility for refunding any money in the case of any such

loss.

> >

> > -- Wakfer

> >

> > MoreLife for the rational - http://morelife.org <http://morelife.org>

> > Reality based tools for more life in quantity and quality

> > The Self-Sovereign Individual Project - http://selfsip.org

> > <http://selfsip.org>

> > Rational freedom by self-sovereignty & social contracting

[Guest guest]

Francesca-The study regarding other components of red wine addressed vascular smooth muscle proliferation only, while studies of resveratrol (RSV) have revealed a panoply of beneficial metabolic effects as well as experimental animal life extension.Additionally, just how much RSV is presentin a Longevinex capsule? It's not clear to me from the list of ingredients.Even if there were 100 mg RSV per Longevinex

capsule, and one got the " bargain " pricing,it would roughly cost me (~60 kg) $1,000/yearto achieve the 5 mg/kg level.At the highest pricing has listed forthe 99% purity, peer reviewed animal study

tested product, I'd be paying approximately$440/year. I already own more than one freezer, and have plenty of space....On 1/18/07, Antonik Wakfer

<paul@...> wrote:

Note from Francesca: A recent study posted here claimed that reservatrol is NOT the main ingredient in wine that benefits longevity. Also another study that claims that reservatrol gives no further benefit to those already on CR. That said, I am myself on a trial of it purchased from the site posted by Maco a few weeks back. I have been taking it for 2 months and notice no difference in my energy level or otherwise. Maco's site is purityproducts.com and the capsules do not need refrigeration orany special handling unlike the bulk purchase that is proposing below. It also has special " deals " at the site and I paid a reasonable price.

Here is 's post:

Notice of Joint Bulk Purchase of >99% Resveratrol

Participants are being sought for a joint bulk purchase of >99% pure

fully synthetic trans-resveratrol from the exact same company (Orchid

Chemicals and Pharmaceuticals Ltd of Chennai, India) that supplied the

resveratrol used in the last two major published mouse feeding studies

http://pmid.us/17086191

http://pmid.us/17112576. In these studies

trans-resveratrol, at human equivalent daily dosages of 5 and 50 mg/kg

respectively, was shown to have major beneficial effects as a calorie

restriction mimetic, and on enhanced mitochondrial activity resulting

in more energy and stamina respectively. The pure synthetic has the

advantage that it is completely free from plant contaminants which may

have negative effects, while being exactly the same chemical as occurs

in nature in red wine (among other sources). In order to obtain a

supply of trans-resveratrol for myself and other interested parties, I

am seeking others to join me in a large bulk purchase so that together

we may get the far lower price per gram that the supplier will give

for a large order. I have already successfully received and

distributed to the initial joint purchase participants 4 kg from

Orchid which is in the process of producing a large new batch to be

ready by mid March 2007. This notice is for the purpose of increasing

the amount that will be ordered at that time, if anyone should be

interested.

Here are the terms of this add-on commitment for new joint bulk

purchase participants.

Terms and Conditions of Joint Bulk Purchase as of Jan 18, 2007

Pricing

100 grams @ $4.00 per gram,

200 grams @ $3.65 per gram,

300 grams @ $3.40 per gram,

400 grams @ $3.25 per gram,

500 grams @ $3.15 per gram.

Packaging

All purchases are packaged in 50 or 100 gm amounts in polypropylene

(PP) zip-lock bags with all air expelled before the bag is closed. PP

bags are much more moisture and air proof than are polyethylene (PE)

bags (the standard that one gets at the supermarket). Each PP bag is

placed in a zip-lock PE sandwich bag for added protection. Multiple

bags are then placed into a bubble envelope which is then placed

inside a USPS flat rate priority mail envelope for shipments of 200

grams or less and a priority box for more than that. (For those

outside the US things will be done a little differently as appropriate

to your import needs.)

Storage, handling and Dosage

If the bags are kept in a freezer (all processes are slower at a lower

temperature), and inside a light proof container (dark bottle or HDPE

container), then research, reading and discussions with others

suggests that there will be little degradation over a period of 2

years. The mice researchers stated nothing about storage in nitrogen

during the experiment and most of the storage time was in a

refrigerator mixed with chow. During actual usage everyone would be

wise to expel all air from the bag whenever it is reclosed after

getting some out of it.

When you remove some resveratrol from a larger package, only remove

enough to last for, say, ten days or 2 weeks at a time and, when not

in use, keep it in a small PP ziplock bag in a dark bottle in the

refrigerator. Small PP zip-lock bags will be enclosed with every

shipment package for the purpose of keeping this smaller in-use amount

in the refrigerator.

As for dosage, standard dosage increasing procedures for any new

chemical suggests that it will be safest to start at 0.5 mg/kg daily

and double every 2 weeks until you reach at least 5 mg/kg (which is

what Dr Sinclair takes and what I am taking), but this is really

a matter of individual choice and desire for experimentation. With

respect to upper limits of dosage, note that there is no evidence of

toxicity for resveratrol even at a human equivalent dosage of 75 mg/kg

- http://pmid.us/15329443.

Shipping and payment

All prices include priority mail (USPS) shipping to US addresses and a

copy of the Certificate of Analysis (COA) of the product.

Insurance of package costs extra.

Out of US shipping incurs a $25 surcharge (only $15 to Canada) with no

customs entry guarantees.

Email me your full legal name, physical and postal addresses, phone

number and amount desired.

Be prepared to pay in advance by check or money order in early March

when the next order with Orchid will need to be placed and prepaid,

since this is a joint bulk purchase and must be prepaid.

I will email you when I need prepayment in March.

Responsibility for Loss

Everyone should be aware that although all joint purchasers received

their allotted share of the first partial shipment, there is always

some possibility that an entire future shipment, or merely a shipment

to a particular joint purchaser, will be lost. Although as the

coordinator of this prepaid joint bulk purchase I promise to do

everything that I possibly can to prevent any such loss, I do not bear

any responsibility for refunding any money in the case of any such loss.

-- Wakfer

MoreLife for the rational - http://morelife.org

Reality based tools for more life in quantity and quality

The Self-Sovereign Individual Project - http://selfsip.org

Rational freedom by self-sovereignty & social contracting

[Guest guest]

Thanks for your supportive comments, Chris.

Also thanks to Francesca for posting my message.

I hoped it would be clear that this is not a high profit making

reselling operation and that the attraction is:

1) the joint bulk purchase is for the exact same product that produced

the spectacular results of the two recent mouse experiments that

captured so much media attention.

2) The price per gram for participants in the joint bulk purchase is

only a little more than the price required to buy the product from

Orchid at the large quantity and far less than Orchid would charge for

the small quantities to which I require each bulk participant to commit.

Here are the quantity prices that Orchid sent me which led me to

decide to try to get buyers for more than 10 kg (which I have already

succeeded in doing).

Orchid's pricing (NOT MINE)

25-50gms @ $7.5/gm

51-100gms @ $7.0/gm

101-500gms @ $6.0/gm

501-999gms @ $5.0/gm

1-10kgs @ $3500/kg

11-50kgs @ $2750/kg

51-100kgs @ $2400/kg

more than 100kgs To be discussed

-- Wakfer

> >

> > Note from Francesca: A recent study posted here claimed that

reservatrol

> > is NOT the main ingredient in wine that benefits longevity. Also

another

> > study that claims that reservatrol gives no further benefit to

those already

> > on CR. That said, I am myself on a trial of it purchased from the site

> > posted by Maco a few weeks back. I have been taking it for 2

months and

> > notice no difference in my energy level or otherwise. Maco's site is

> > purityproducts.com and the capsules do not need refrigeration orany

> > special handling unlike the bulk purchase that is proposing

below. It

> > also has special " deals " at the site and I paid a reasonable price.

> >

> > Here is 's post:

> >

> > Notice of Joint Bulk Purchase of >99% Resveratrol

> >

> > Participants are being sought for a joint bulk purchase of >99% pure

> > fully synthetic trans-resveratrol from the exact same company (Orchid

> > Chemicals and Pharmaceuticals Ltd of Chennai, India) that supplied the

> > resveratrol used in the last two major published mouse feeding studies

> > http://pmid.us/17086191 http://pmid.us/17112576. In these studies

> > trans-resveratrol, at human equivalent daily dosages of 5 and 50 mg/kg

> > respectively, was shown to have major beneficial effects as a calorie

> > restriction mimetic, and on enhanced mitochondrial activity resulting

> > in more energy and stamina respectively. The pure synthetic has the

> > advantage that it is completely free from plant contaminants which may

> > have negative effects, while being exactly the same chemical as occurs

> > in nature in red wine (among other sources). In order to obtain a

> > supply of trans-resveratrol for myself and other interested parties, I

> > am seeking others to join me in a large bulk purchase so that together

> > we may get the far lower price per gram that the supplier will give

> > for a large order. I have already successfully received and

> > distributed to the initial joint purchase participants 4 kg from

> > Orchid which is in the process of producing a large new batch to be

> > ready by mid March 2007. This notice is for the purpose of increasing

> > the amount that will be ordered at that time, if anyone should be

> > interested.

> >

> > Here are the terms of this add-on commitment for new joint bulk

> > purchase participants.

> >

> > Terms and Conditions of Joint Bulk Purchase as of Jan 18, 2007

> >

> > Pricing

> >

> > 100 grams @ $4.00 per gram,

> > 200 grams @ $3.65 per gram,

> > 300 grams @ $3.40 per gram,

> > 400 grams @ $3.25 per gram,

> > 500 grams @ $3.15 per gram.

> >

> > Packaging

> >

> > All purchases are packaged in 50 or 100 gm amounts in polypropylene

> > (PP) zip-lock bags with all air expelled before the bag is closed. PP

> > bags are much more moisture and air proof than are polyethylene (PE)

> > bags (the standard that one gets at the supermarket). Each PP bag is

> > placed in a zip-lock PE sandwich bag for added protection. Multiple

> > bags are then placed into a bubble envelope which is then placed

> > inside a USPS flat rate priority mail envelope for shipments of 200

> > grams or less and a priority box for more than that. (For those

> > outside the US things will be done a little differently as appropriate

> > to your import needs.)

> >

> > Storage, handling and Dosage

> >

> > If the bags are kept in a freezer (all processes are slower at a lower

> > temperature), and inside a light proof container (dark bottle or HDPE

> > container), then research, reading and discussions with others

> > suggests that there will be little degradation over a period of 2

> > years. The mice researchers stated nothing about storage in nitrogen

> > during the experiment and most of the storage time was in a

> > refrigerator mixed with chow. During actual usage everyone would be

> > wise to expel all air from the bag whenever it is reclosed after

> > getting some out of it.

> >

> > When you remove some resveratrol from a larger package, only remove

> > enough to last for, say, ten days or 2 weeks at a time and, when not

> > in use, keep it in a small PP ziplock bag in a dark bottle in the

> > refrigerator. Small PP zip-lock bags will be enclosed with every

> > shipment package for the purpose of keeping this smaller in-use amount

> > in the refrigerator.

> >

> > As for dosage, standard dosage increasing procedures for any new

> > chemical suggests that it will be safest to start at 0.5 mg/kg daily

> > and double every 2 weeks until you reach at least 5 mg/kg (which is

> > what Dr Sinclair takes and what I am taking), but this is really

> > a matter of individual choice and desire for experimentation. With

> > respect to upper limits of dosage, note that there is no evidence of

> > toxicity for resveratrol even at a human equivalent dosage of 75 mg/kg

> > - http://pmid.us/15329443.

> >

> > Shipping and payment

> >

> > All prices include priority mail (USPS) shipping to US addresses and a

> > copy of the Certificate of Analysis (COA) of the product.

> > Insurance of package costs extra.

> > Out of US shipping incurs a $25 surcharge (only $15 to Canada) with no

> > customs entry guarantees.

> > Email me your full legal name, physical and postal addresses, phone

> > number and amount desired.

> > Be prepared to pay in advance by check or money order in early March

> > when the next order with Orchid will need to be placed and prepaid,

> > since this is a joint bulk purchase and must be prepaid.

> > I will email you when I need prepayment in March.

> >

> > Responsibility for Loss

> >

> > Everyone should be aware that although all joint purchasers received

> > their allotted share of the first partial shipment, there is always

> > some possibility that an entire future shipment, or merely a shipment

> > to a particular joint purchaser, will be lost. Although as the

> > coordinator of this prepaid joint bulk purchase I promise to do

> > everything that I possibly can to prevent any such loss, I do not bear

> > any responsibility for refunding any money in the case of any such

loss.

> >

> > -- Wakfer

> >

> > MoreLife for the rational - http://morelife.org

> > Reality based tools for more life in quantity and quality

> > The Self-Sovereign Individual Project - http://selfsip.org

> > Rational freedom by self-sovereignty & social contracting

> >

> >

> >

>

[Guest guest]

On Thursday 18 January 2007 11:24 pm, Antonik Wakfer wrote:

>

> > Hi ,

> > Ten times the amount is a pretty big jump IMO.

>

> I certainly agree with that, however, major benefits take place at far

> less. Personally, I do not plan to exceed 20 mg/kg unless there is

> major additional evidence such as a life extension or longer term lack

> of toxicity result.

>

> -- Wakfer

So for a 70K person, that would be 1.4 grams per day? For some reason, I was

under the impression that the studies scaled up to something like 400 mg/day.

--

Steve - dudescholar3@...

" Diplomacy is the art of letting someone else have your way. "

--e Vare

[Guest guest]

The capsules equal 5 to 15 glasses of red wine (true that it's vague). The cost is much less than what you mention below. (About $240 for a 5 month supply).

More on this later when I have the chance to reply in more detail.

on 1/18/2007 9:27 PM, Dowling at christopher.a.dowling@... wrote:

Francesca-

The study regarding other components of red wine

addressed vascular smooth muscle proliferation only,

while studies of resveratrol (RSV) have revealed

a panoply of beneficial metabolic effects as

well as experimental animal life extension.

Additionally, just how much RSV is present

in a Longevinex capsule? It's not clear to

me from the list of ingredients.

Even if there were 100 mg RSV per Longevinex

capsule, and one got the " bargain " pricing,

it would roughly cost me (~60 kg) $1,000/year

to achieve the 5 mg/kg level.

At the highest pricing has listed for

the 99% purity, peer reviewed animal study

tested product, I'd be paying approximately

$440/year. I already own more than one

freezer, and have plenty of space....

On 1/18/07, Antonik Wakfer <paul@...> wrote:

Note from Francesca: A recent study posted here claimed that reservatrol is NOT the main ingredient in wine that benefits longevity. Also another study that claims that reservatrol gives no further benefit to those already on CR. That said, I am myself on a trial of it purchased from the site posted by Maco a few weeks back. I have been taking it for 2 months and notice no difference in my energy level or otherwise. Maco's site is purityproducts.com <http://purityproducts.com> and the capsules do not need refrigeration orany special handling unlike the bulk purchase that is proposing below. It also has special " deals " at the site and I paid a reasonable price.

Here is 's post:

Notice of Joint Bulk Purchase of >99% Resveratrol

Participants are being sought for a joint bulk purchase of >99% pure

fully synthetic trans-resveratrol from the exact same company (Orchid

Chemicals and Pharmaceuticals Ltd of Chennai, India) that supplied the

resveratrol used in the last two major published mouse feeding studies

http://pmid.us/17086191 http://pmid.us/17112576. In these studies

trans-resveratrol, at human equivalent daily dosages of 5 and 50 mg/kg

respectively, was shown to have major beneficial effects as a calorie

restriction mimetic, and on enhanced mitochondrial activity resulting

in more energy and stamina respectively. The pure synthetic has the

advantage that it is completely free from plant contaminants which may

have negative effects, while being exactly the same chemical as occurs

in nature in red wine (among other sources). In order to obtain a

supply of trans-resveratrol for myself and other interested parties, I

am seeking others to join me in a large bulk purchase so that together

we may get the far lower price per gram that the supplier will give

for a large order. I have already successfully received and

distributed to the initial joint purchase participants 4 kg from

Orchid which is in the process of producing a large new batch to be

ready by mid March 2007. This notice is for the purpose of increasing

the amount that will be ordered at that time, if anyone should be

interested.

Here are the terms of this add-on commitment for new joint bulk

purchase participants.

Terms and Conditions of Joint Bulk Purchase as of Jan 18, 2007

Pricing

100 grams @ $4.00 per gram,

200 grams @ $3.65 per gram,

300 grams @ $3.40 per gram,

400 grams @ $3.25 per gram,

500 grams @ $3.15 per gram.

Packaging

All purchases are packaged in 50 or 100 gm amounts in polypropylene

(PP) zip-lock bags with all air expelled before the bag is closed. PP

bags are much more moisture and air proof than are polyethylene (PE)

bags (the standard that one gets at the supermarket). Each PP bag is

placed in a zip-lock PE sandwich bag for added protection. Multiple

bags are then placed into a bubble envelope which is then placed

inside a USPS flat rate priority mail envelope for shipments of 200

grams or less and a priority box for more than that. (For those

outside the US things will be done a little differently as appropriate

to your import needs.)

Storage, handling and Dosage

If the bags are kept in a freezer (all processes are slower at a lower

temperature), and inside a light proof container (dark bottle or HDPE

container), then research, reading and discussions with others

suggests that there will be little degradation over a period of 2

years. The mice researchers stated nothing about storage in nitrogen

during the experiment and most of the storage time was in a

refrigerator mixed with chow. During actual usage everyone would be

wise to expel all air from the bag whenever it is reclosed after

getting some out of it.

When you remove some resveratrol from a larger package, only remove

enough to last for, say, ten days or 2 weeks at a time and, when not

in use, keep it in a small PP ziplock bag in a dark bottle in the

refrigerator. Small PP zip-lock bags will be enclosed with every

shipment package for the purpose of keeping this smaller in-use amount

in the refrigerator.

As for dosage, standard dosage increasing procedures for any new

chemical suggests that it will be safest to start at 0.5 mg/kg daily

and double every 2 weeks until you reach at least 5 mg/kg (which is

what Dr Sinclair takes and what I am taking), but this is really

a matter of individual choice and desire for experimentation. With

respect to upper limits of dosage, note that there is no evidence of

toxicity for resveratrol even at a human equivalent dosage of 75 mg/kg

- http://pmid.us/15329443.

Shipping and payment

All prices include priority mail (USPS) shipping to US addresses and a

copy of the Certificate of Analysis (COA) of the product.

Insurance of package costs extra.

Out of US shipping incurs a $25 surcharge (only $15 to Canada) with no

customs entry guarantees.

Email me your full legal name, physical and postal addresses, phone

number and amount desired.

Be prepared to pay in advance by check or money order in early March

when the next order with Orchid will need to be placed and prepaid,

since this is a joint bulk purchase and must be prepaid.

I will email you when I need prepayment in March.

Responsibility for Loss

Everyone should be aware that although all joint purchasers received

their allotted share of the first partial shipment, there is always

some possibility that an entire future shipment, or merely a shipment

to a particular joint purchaser, will be lost. Although as the

coordinator of this prepaid joint bulk purchase I promise to do

everything that I possibly can to prevent any such loss, I do not bear

any responsibility for refunding any money in the case of any such loss.

-- Wakfer

MoreLife for the rational - http://morelife.org

Reality based tools for more life in quantity and quality

The Self-Sovereign Individual Project - http://selfsip.org

Rational freedom by self-sovereignty & social contracting

[Guest guest]

It sounds to me as though in

terms of quantity, this offer is probably a good deal, assuming of course

that the quality is as claimed. One of the things Longevinex (which I

take) touts or perhaps hypes is that they process, package, and

seal/encapsulate their red-wine extracted stuff in an oxygen-free

(nitrogen) environment, thereby avoiding the oxidation degradation that

begins to reduce the usefulness of resveratrol as soon as one, for

example, opens a bottle of red wine. So my concern would be about how to

avoid having one's stash of stuff come in contact with those pesky oxygen

atoms either before you get it or afterward and what effect the

inevitable oxygen contamination of the bulk supplies might have on the

eventual efficacy of the product.

If one lives on the moon, then this ceases to be a problem, of course . .

.. .

Maco

on 1/18/2007 9:27 PM,

Dowling at christopher.a.dowling@... wrote:

Francesca-

The study regarding other components of red wine

addressed vascular smooth muscle proliferation only,

while studies of resveratrol (RSV) have revealed

a panoply of beneficial metabolic effects as

well as experimental animal life extension.

Additionally, just how much RSV is present

in a Longevinex capsule? It's not clear to

me from the list of ingredients.

Even if there were 100 mg RSV per Longevinex

capsule, and one got the " bargain " pricing,

it would roughly cost me (~60 kg) $1,000/year

to achieve the 5 mg/kg level.

At the highest pricing has listed for

the 99% purity, peer reviewed animal study

tested product, I'd be paying approximately

$440/year. I already own more than one

freezer, and have plenty of space....

On 1/18/07, Antonik Wakfer <paul@...>

wrote:

Note from Francesca: A recent study posted here claimed that

reservatrol is NOT the main ingredient in wine that benefits

longevity. Also another study that claims that reservatrol gives no

further benefit to those already on CR. That said, I am myself on a

trial of it purchased from the site posted by Maco a few weeks

back. I have been taking it for 2 months and notice no

difference in my energy level or otherwise. Maco's site is

purityproducts.com

<

http://purityproducts.com> and the capsules do not need

refrigeration orany special handling unlike the bulk purchase that

is proposing below. It also has special " deals " at the

site and I paid a reasonable price.

Here is 's post:

Notice of Joint Bulk Purchase of >99% Resveratrol

Participants are being sought for a joint bulk purchase of >99%

pure

fully synthetic trans-resveratrol from the exact same company

(Orchid

Chemicals and Pharmaceuticals Ltd of Chennai, India) that supplied

the

resveratrol used in the last two major published mouse feeding

studies

http://pmid.us/17086191

http://pmid.us/17112576. In these studies

trans-resveratrol, at human equivalent daily dosages of 5 and 50

mg/kg

respectively, was shown to have major beneficial effects as a

calorie

restriction mimetic, and on enhanced mitochondrial activity

resulting

in more energy and stamina respectively. The pure synthetic has

the

advantage that it is completely free from plant contaminants which

may

have negative effects, while being exactly the same chemical as

occurs

in nature in red wine (among other sources). In order to obtain

a

supply of trans-resveratrol for myself and other interested parties,

I

am seeking others to join me in a large bulk purchase so that

together

we may get the far lower price per gram that the supplier will

give

for a large order. I have already successfully received and

distributed to the initial joint purchase participants 4 kg from

Orchid which is in the process of producing a large new batch to

be

ready by mid March 2007. This notice is for the purpose of

increasing

the amount that will be ordered at that time, if anyone should

be

interested.

Here are the terms of this add-on commitment for new joint bulk

purchase participants.

Terms and Conditions of Joint Bulk Purchase as of Jan 18,

2007

Pricing

100 grams @ $4.00 per gram,

200 grams @ $3.65 per gram,

300 grams @ $3.40 per gram,

400 grams @ $3.25 per gram,

500 grams @ $3.15 per gram.

Packaging

All purchases are packaged in 50 or 100 gm amounts in

polypropylene

(PP) zip-lock bags with all air expelled before the bag is closed.

PP

bags are much more moisture and air proof than are polyethylene

(PE)

bags (the standard that one gets at the supermarket). Each PP bag

is

placed in a zip-lock PE sandwich bag for added protection.

Multiple

bags are then placed into a bubble envelope which is then placed

inside a USPS flat rate priority mail envelope for shipments of

200

grams or less and a priority box for more than that. (For those

outside the US things will be done a little differently as

appropriate

to your import needs.)

Storage, handling and Dosage

If the bags are kept in a freezer (all processes are slower at a

lower

temperature), and inside a light proof container (dark bottle or

HDPE

container), then research, reading and discussions with others

suggests that there will be little degradation over a period of

2

years. The mice researchers stated nothing about storage in

nitrogen

during the experiment and most of the storage time was in a

refrigerator mixed with chow. During actual usage everyone would

be

wise to expel all air from the bag whenever it is reclosed after

getting some out of it.

When you remove some resveratrol from a larger package, only

remove

enough to last for, say, ten days or 2 weeks at a time and, when

not

in use, keep it in a small PP ziplock bag in a dark bottle in

the

refrigerator. Small PP zip-lock bags will be enclosed with every

shipment package for the purpose of keeping this smaller in-use

amount

in the refrigerator.

As for dosage, standard dosage increasing procedures for any new

chemical suggests that it will be safest to start at 0.5 mg/kg

daily

and double every 2 weeks until you reach at least 5 mg/kg (which

is

what Dr Sinclair takes and what I am taking), but this is

really

a matter of individual choice and desire for experimentation.

With

respect to upper limits of dosage, note that there is no evidence

of

toxicity for resveratrol even at a human equivalent dosage of 75

mg/kg

-

http://pmid.us/15329443.

Shipping and payment

All prices include priority mail (USPS) shipping to US addresses and

a

copy of the Certificate of Analysis (COA) of the product.

Insurance of package costs extra.

Out of US shipping incurs a $25 surcharge (only $15 to Canada) with

no

customs entry guarantees.

Email me your full legal name, physical and postal addresses,

phone

number and amount desired.

Be prepared to pay in advance by check or money order in early

March

when the next order with Orchid will need to be placed and

prepaid,

since this is a joint bulk purchase and must be prepaid.

I will email you when I need prepayment in March.

Responsibility for Loss

Everyone should be aware that although all joint purchasers

received

their allotted share of the first partial shipment, there is

always

some possibility that an entire future shipment, or merely a

shipment

to a particular joint purchaser, will be lost. Although as the

coordinator of this prepaid joint bulk purchase I promise to do

everything that I possibly can to prevent any such loss, I do not

bear

any responsibility for refunding any money in the case of any such

loss.

-- Wakfer

MoreLife for the rational -

http://morelife.org

Reality based tools for more life in quantity and quality

The Self-Sovereign Individual Project -

http://selfsip.org

Rational freedom by self-sovereignty & social

contracting

[Guest guest]

> > > Hi ,

>

> > > Ten times the amount is a pretty big jump IMO.

> >

> > I certainly agree with that, however, major benefits take place at far

> > less. Personally, I do not plan to exceed 20 mg/kg unless there is

> > major additional evidence such as a life extension or longer term lack

> > of toxicity result.

> >

> > -- Wakfer

>

> So for a 70K person, that would be 1.4 grams per day? For some

reason, I was

> under the impression that the studies scaled up to something like

400 mg/day.

The Sinclair study used 5.2 and 22.4 mg/kg body weight for mice and

the Auwerx study (which had the dramatic mitochondrial activity

effects), used 200 and 400 mg/kg. The scaling factor from mice to

humans is about 6.5, but varies with the weight of the mouse and human

(it is the 1/4 power of the ratio of the body weights). So the human

equivalent dosages turn out to be roughly 5 mg/kg and 50 mg/kg. These

are " ball-park " numbers since there is no really accurate way to

detail a human dosage from an animal dosage. That is why drug trials

are often done with different dosages. The reason that I mentioned 20

mg/kg is because that is the highest dosage that I would be willing to

take in order to potentially get some of the mitochondrial benefits,

unless and until there are more long-terms tests done.

-- Wakfer

MoreLife for the rational - http://morelife.org

Reality based tools for more life in quantity and quality

The Self-Sovereign Individual Project - http://selfsip.org

Rational freedom by self-sovereignty & social contracting

[Guest guest]

Hi All,

Actually, this topic of the various purities and ingredients in

resveratrol supplements on the market has been covered in the Forums

section of the Immortality Institute website. Several people on those

boards are now taking 500mg of trans-resveratrol per day(!) and intend to

post their bloodwork later. Check out the Supplement postings here:

http://www.imminst.org/forum/index.php?s= & act=SF & f=6

The boards seem pretty good, a lot of scientist types on there, most

claims must be backed up with research, data, etc. Sounds like a few

CRonies as well....

You can spend quite a bit of time there but there are several resveratrol

specific threads that are worth reading if you are into that topic.

Cheers,

-W

>

> <!DOCTYPE HTML PUBLIC " -//W3C//DTD HTML 4.01//EN "

> " http://www.w3.org/TR/html4/strict.dtd " >

> <html>

> <head>

> </head>

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> <p>

>

> <blockquote type= " cite " class= " cite " cite>It sounds to me as though in

> terms of quantity, this offer is probably a good deal, assuming of course

> that the quality is as claimed. One of the things Longevinex (which I

> take) touts or perhaps hypes is that they process, package, and

> seal/encapsulate their red-wine extracted stuff in an oxygen-free

> (nitrogen) environment, thereby avoiding the oxidation degradation that

> begins to reduce the usefulness of resveratrol as soon as one, for

> example, opens a bottle of red wine. So my concern would be about how to

> avoid having one's stash of stuff come in contact with those pesky oxygen

> atoms either before you get it or afterward and what effect the

> inevitable oxygen contamination of the bulk supplies might have on the

> eventual efficacy of the product.</blockquote><br>

> If one lives on the moon, then this ceases to be a problem, of course . .

> . .<br><br>

> Maco<br><br>

> <br><br>

> <blockquote type= " cite " class= " cite " cite>on 1/18/2007 9:27 PM,

> Dowling at christopher.<wbr>a.dowling@<wbr>gmail.com

> wrote:<br><br>

>

> <dl>

> <dd>Francesca-<br><br>

>

> <dd>The study regarding other components of red wine <br>

>

> <dd>addressed vascular smooth muscle proliferation only, <br>

>

> <dd>while studies of resveratrol (RSV) have revealed <br>

>

> <dd>a panoply of beneficial metabolic effects as <br>

>

> <dd>well as experimental animal life extension.<br><br>

>

> <dd>Additionally, just how much RSV is present<br>

>

> <dd>in a Longevinex capsule? It's not clear to <br>

>

> <dd>me from the list of ingredients.<br><br>

>

> <dd>Even if there were 100 mg RSV per Longevinex <br>

>

> <dd>capsule, and one got the " bargain " pricing,<br>

>

> <dd>it would roughly cost me (~60 kg) $1,000/year<br>

>

> <dd>to achieve the 5 mg/kg level.<br><br>

>

> <dd>At the highest pricing has listed for<br>

>

> <dd>the 99% purity, peer reviewed animal study <br>

>

> <dd>tested product, I'd be paying approximately<br>

>

> <dd>$440/year. I already own more than one <br>

>

> <dd>freezer, and have plenty of space....<br><br>

>

> <dd>On 1/18/07, Antonik Wakfer

> </b><paulmorelife (DOT) <wbr>org>

> wrote:<br>

>

> <dl>

> <dd>Note from Francesca: A recent study posted here claimed that

> reservatrol is NOT the main ingredient in wine that benefits

> longevity. Also another study that claims that reservatrol gives no

> further benefit to those already on CR. That said, I am myself on a

> trial of it purchased from the site posted by Maco a few weeks

> back. I have been taking it for 2 months and notice no

> difference in my energy level or otherwise. Maco's site is

> purityproducts.<wbr>com

> <<a href= " http://purityproducts.com/ " eudora= " autourl " >

> http://purityproduc<wbr>ts.com</a>> and the capsules do not

> need

> refrigeration orany special handling unlike the bulk purchase that

> is proposing below. It also has special " deals " at the

> site and I paid a reasonable price. <br><br>

>

> <dd>Here is 's post: <br><br>

>

> <dd>Notice of Joint Bulk Purchase of >99% Resveratrol<br><br>

>

> <dd>Participants are being sought for a joint bulk purchase of >99%

> pure<br>

>

> <dd>fully synthetic trans-resveratrol from the exact same company

> (Orchid<br>

>

> <dd>Chemicals and Pharmaceuticals Ltd of Chennai, India) that supplied

> the<br>

>

> <dd>resveratrol used in the last two major published mouse feeding

> studies<br>

>

> <dd><a href= " http://pmid.us/17086191 " eudora= " autourl " >

> http://pmid.<wbr>us/17086191</a>

> <a href= " http://pmid.us/17112576 " eudora= " autourl " >

> http://pmid.<wbr>us/17112576</a>. In these studies<br>

>

> <dd>trans-resveratrol, at human equivalent daily dosages of 5 and 50

> mg/kg<br>

>

> <dd>respectively, was shown to have major beneficial effects as a

> calorie<br>

>

> <dd>restriction mimetic, and on enhanced mitochondrial activity

> resulting<br>

>

> <dd>in more energy and stamina respectively. The pure synthetic has

> the<br>

>

> <dd>advantage that it is completely free from plant contaminants which

> may<br>

>

> <dd>have negative effects, while being exactly the same chemical as

> occurs<br>

>

> <dd>in nature in red wine (among other sources). In order to obtain

> a<br>

>

> <dd>supply of trans-resveratrol for myself and other interested

> parties,

> I<br>

>

> <dd>am seeking others to join me in a large bulk purchase so that

> together<br>

>

> <dd>we may get the far lower price per gram that the supplier will

> give<br>

>

> <dd>for a large order. I have already successfully received and<br>

>

> <dd>distributed to the initial joint purchase participants 4 kg

> from<br>

>

> <dd>Orchid which is in the process of producing a large new batch to

> be<br>

>

> <dd>ready by mid March 2007. This notice is for the purpose of

> increasing<br>

>

> <dd>the amount that will be ordered at that time, if anyone should

> be<br>

>

> <dd>interested.<br><br>

>

> <dd>Here are the terms of this add-on commitment for new joint

> bulk<br>

>

> <dd>purchase participants.<br><br>

>

> <dd>Terms and Conditions of Joint Bulk Purchase as of Jan 18,

> 2007<br><br>

>

> <dd>Pricing<br><br>

>

> <dd>100 grams @ $4.00 per gram,<br>

>

> <dd>200 grams @ $3.65 per gram,<br>

>

> <dd>300 grams @ $3.40 per gram,<br>

>

> <dd>400 grams @ $3.25 per gram,<br>

>

> <dd>500 grams @ $3.15 per gram.<br><br>

>

> <dd>Packaging<br><br>

>

> <dd>All purchases are packaged in 50 or 100 gm amounts in

> polypropylene<br>

>

> <dd>(PP) zip-lock bags with all air expelled before the bag is closed.

> PP<br>

>

> <dd>bags are much more moisture and air proof than are polyethylene

> (PE)<br>

>

> <dd>bags (the standard that one gets at the supermarket)<wbr>. Each

> PP bag

> is<br>

>

> <dd>placed in a zip-lock PE sandwich bag for added protection.

> Multiple<br>

>

> <dd>bags are then placed into a bubble envelope which is then

> placed<br>

>

> <dd>inside a USPS flat rate priority mail envelope for shipments of

> 200<br>

>

> <dd>grams or less and a priority box for more than that. (For

> those<br>

>

> <dd>outside the US things will be done a little differently as

> appropriate<br>

>

> <dd>to your import needs.)<br><br>

>

> <dd>Storage, handling and Dosage<br><br>

>

> <dd>If the bags are kept in a freezer (all processes are slower at a

> lower<br>

>

> <dd>temperature)<wbr>, and inside a light proof container (dark

> bottle or

> HDPE<br>

>

> <dd>container), then research, reading and discussions with

> others<br>

>

> <dd>suggests that there will be little degradation over a period of

> 2<br>

>

> <dd>years. The mice researchers stated nothing about storage in

> nitrogen<br>

>

> <dd>during the experiment and most of the storage time was in a<br>

>

> <dd>refrigerator mixed with chow. During actual usage everyone would

> be<br>

>

> <dd>wise to expel all air from the bag whenever it is reclosed

> after<br>

>

> <dd>getting some out of it.<br><br>

>

> <dd>When you remove some resveratrol from a larger package, only

> remove<br>

>

> <dd>enough to last for, say, ten days or 2 weeks at a time and, when

> not<br>

>

> <dd>in use, keep it in a small PP ziplock bag in a dark bottle in

> the<br>

>

> <dd>refrigerator. Small PP zip-lock bags will be enclosed with

> every<br>

>

> <dd>shipment package for the purpose of keeping this smaller in-use

> amount<br>

>

> <dd>in the refrigerator.<br><br>

>

> <dd>As for dosage, standard dosage increasing procedures for any

> new<br>

>

> <dd>chemical suggests that it will be safest to start at 0.5 mg/kg

> daily<br>

>

> <dd>and double every 2 weeks until you reach at least 5 mg/kg (which

> is<br>

>

> <dd>what Dr Sinclair takes and what I am taking), but this is

> really<br>

>

> <dd>a matter of individual choice and desire for experimentation.

> With<br>

>

> <dd>respect to upper limits of dosage, note that there is no evidence

> of<br>

>

> <dd>toxicity for resveratrol even at a human equivalent dosage of 75

> mg/kg<br>

>

> <dd>-

> <a href= " http://pmid.us/15329443 " eudora= " autourl " >

> http://pmid.<wbr>us/15329443</a>.<br><br>

>

> <dd>Shipping and payment<br><br>

>

> <dd>All prices include priority mail (USPS) shipping to US addresses

> and

> a<br>

>

> <dd>copy of the Certificate of Analysis (COA) of the product.<br>

>

> <dd>Insurance of package costs extra.<br>

>

> <dd>Out of US shipping incurs a $25 surcharge (only $15 to Canada)

> with

> no<br>

>

> <dd>customs entry guarantees.<br>

>

> <dd>Email me your full legal name, physical and postal addresses,

> phone<br>

>

> <dd>number and amount desired.<br>

>

> <dd>Be prepared to pay in advance by check or money order in early

> March<br>

>

> <dd>when the next order with Orchid will need to be placed and

> prepaid,<br>

>

> <dd>since this is a joint bulk purchase and must be prepaid.<br>

>

> <dd>I will email you when I need prepayment in March.<br>

> <br>

>

> <dd>Responsibility for Loss<br><br>

>

> <dd>Everyone should be aware that although all joint purchasers

> received<br>

>

> <dd>their allotted share of the first partial shipment, there is

> always<br>

>

> <dd>some possibility that an entire future shipment, or merely a

> shipment<br>

>

> <dd>to a particular joint purchaser, will be lost. Although as

> the<br>

>

> <dd>coordinator of this prepaid joint bulk purchase I promise to

> do<br>

>

> <dd>everything that I possibly can to prevent any such loss, I do not

> bear<br>

>

> <dd>any responsibility for refunding any money in the case of any such

> loss.<br><br>

>

> <dd>-- Wakfer<br><br>

>

> <dd>MoreLife for the rational -

> <a href= " http://morelife.org/ "

> eudora= " autourl " >http://morelife.<wbr>org</a>

> <br>

>

> <dd>Reality based tools for more life in quantity and quality<br>

>

> <dd>The Self-Sovereign Individual Project -

> <a href= " http://selfsip.org/ "

> eudora= " autourl " >http://selfsip.<wbr>org</a><br>

>

> <dd>Rational freedom by self-sovereignty & social

> contracting<br><br>

>

> <dd> <br><br>

>

> </dl><br><br>

>

> </dl><br>

> </blockquote>

> <x><p></x>

> <br>

>

>

>

> </p>

> </div>

>

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>

Jewell, Ph.D.

Campus Mass Spectrometry Facilities

UC

cmsf.ucdavis.edu

[Guest guest]

With all this suggestive talk of resveratrol in capsule form, where is

the compelling evidence? What is proper dosage? Is it safe? Any risk?

What are the specific benefits of resveratrol supplementation? I don't

currently take this supplement but I will reconsider if someone will

(re)post the relevant research. Thank you very much.

bill

> > >

> > > Note from Francesca: A recent study posted here claimed that

> reservatrol

> > > is NOT the main ingredient in wine that benefits longevity. Also

> another

> > > study that claims that reservatrol gives no further benefit to

> those already

> > > on CR. That said, I am myself on a trial of it purchased from

the site

> > > posted by Maco a few weeks back. I have been taking it for 2

> months and

> > > notice no difference in my energy level or otherwise. Maco's site is

> > > purityproducts.com and the capsules do not need refrigeration orany

> > > special handling unlike the bulk purchase that is proposing

> below. It

> > > also has special " deals " at the site and I paid a reasonable price.

> > >

> > > Here is 's post:

> > >

> > > Notice of Joint Bulk Purchase of >99% Resveratrol

> > >

> > > Participants are being sought for a joint bulk purchase of >99% pure

> > > fully synthetic trans-resveratrol from the exact same company

(Orchid

> > > Chemicals and Pharmaceuticals Ltd of Chennai, India) that

supplied the

> > > resveratrol used in the last two major published mouse feeding

studies

> > > http://pmid.us/17086191 http://pmid.us/17112576. In these studies

> > > trans-resveratrol, at human equivalent daily dosages of 5 and 50

mg/kg

> > > respectively, was shown to have major beneficial effects as a

calorie

> > > restriction mimetic, and on enhanced mitochondrial activity

resulting

> > > in more energy and stamina respectively. The pure synthetic has the

> > > advantage that it is completely free from plant contaminants

which may

> > > have negative effects, while being exactly the same chemical as

occurs

> > > in nature in red wine (among other sources). In order to obtain a

> > > supply of trans-resveratrol for myself and other interested

parties, I

> > > am seeking others to join me in a large bulk purchase so that

together

> > > we may get the far lower price per gram that the supplier will give

> > > for a large order. I have already successfully received and

> > > distributed to the initial joint purchase participants 4 kg from

> > > Orchid which is in the process of producing a large new batch to be

> > > ready by mid March 2007. This notice is for the purpose of

increasing

> > > the amount that will be ordered at that time, if anyone should be

> > > interested.

> > >

> > > Here are the terms of this add-on commitment for new joint bulk

> > > purchase participants.

> > >

> > > Terms and Conditions of Joint Bulk Purchase as of Jan 18, 2007

> > >

> > > Pricing

> > >

> > > 100 grams @ $4.00 per gram,

> > > 200 grams @ $3.65 per gram,

> > > 300 grams @ $3.40 per gram,

> > > 400 grams @ $3.25 per gram,

> > > 500 grams @ $3.15 per gram.

> > >

> > > Packaging

> > >

> > > All purchases are packaged in 50 or 100 gm amounts in polypropylene

> > > (PP) zip-lock bags with all air expelled before the bag is

closed. PP

> > > bags are much more moisture and air proof than are polyethylene (PE)

> > > bags (the standard that one gets at the supermarket). Each PP bag is

> > > placed in a zip-lock PE sandwich bag for added protection. Multiple

> > > bags are then placed into a bubble envelope which is then placed

> > > inside a USPS flat rate priority mail envelope for shipments of 200

> > > grams or less and a priority box for more than that. (For those

> > > outside the US things will be done a little differently as

appropriate

> > > to your import needs.)

> > >

> > > Storage, handling and Dosage

> > >

> > > If the bags are kept in a freezer (all processes are slower at a

lower

> > > temperature), and inside a light proof container (dark bottle or

HDPE

> > > container), then research, reading and discussions with others

> > > suggests that there will be little degradation over a period of 2

> > > years. The mice researchers stated nothing about storage in nitrogen

> > > during the experiment and most of the storage time was in a

> > > refrigerator mixed with chow. During actual usage everyone would be

> > > wise to expel all air from the bag whenever it is reclosed after

> > > getting some out of it.

> > >

> > > When you remove some resveratrol from a larger package, only remove

> > > enough to last for, say, ten days or 2 weeks at a time and, when not

> > > in use, keep it in a small PP ziplock bag in a dark bottle in the

> > > refrigerator. Small PP zip-lock bags will be enclosed with every

> > > shipment package for the purpose of keeping this smaller in-use

amount

> > > in the refrigerator.

> > >

> > > As for dosage, standard dosage increasing procedures for any new

> > > chemical suggests that it will be safest to start at 0.5 mg/kg daily

> > > and double every 2 weeks until you reach at least 5 mg/kg (which is

> > > what Dr Sinclair takes and what I am taking), but this is

really

> > > a matter of individual choice and desire for experimentation. With

> > > respect to upper limits of dosage, note that there is no evidence of

> > > toxicity for resveratrol even at a human equivalent dosage of 75

mg/kg

> > > - http://pmid.us/15329443.

> > >

> > > Shipping and payment

> > >

> > > All prices include priority mail (USPS) shipping to US addresses

and a

> > > copy of the Certificate of Analysis (COA) of the product.

> > > Insurance of package costs extra.

> > > Out of US shipping incurs a $25 surcharge (only $15 to Canada)

with no

> > > customs entry guarantees.

> > > Email me your full legal name, physical and postal addresses, phone

> > > number and amount desired.

> > > Be prepared to pay in advance by check or money order in early March

> > > when the next order with Orchid will need to be placed and prepaid,

> > > since this is a joint bulk purchase and must be prepaid.

> > > I will email you when I need prepayment in March.

> > >

> > > Responsibility for Loss

> > >

> > > Everyone should be aware that although all joint purchasers received

> > > their allotted share of the first partial shipment, there is always

> > > some possibility that an entire future shipment, or merely a

shipment

> > > to a particular joint purchaser, will be lost. Although as the

> > > coordinator of this prepaid joint bulk purchase I promise to do

> > > everything that I possibly can to prevent any such loss, I do

not bear

> > > any responsibility for refunding any money in the case of any such

> loss.

> > >

> > > -- Wakfer

> > >

> > > MoreLife for the rational - http://morelife.org

> > > Reality based tools for more life in quantity and quality

> > > The Self-Sovereign Individual Project - http://selfsip.org

> > > Rational freedom by self-sovereignty & social contracting

> > >

> > >

> > >

> >

>

[Guest guest]

Here is the posting on resveratrol vs the polyphenols in wine:

/message/24571

According to this study, it's not only coronary disease but longevity that is in question. (Unless I'm reading it incorrectly).

As Maco mentioned, ' s resveratrol (if one still wants to take it without waiting for more confirmation as to exactly which substance promotes longevity) needs much TLC. I'm sticking with the capsules which are sealed , tamper proof and don't need refrigeration or any special handling. I already stash my nuts in the freezer, olive oil in the fridge etc and have enough special handling " foods and supplements.

To each his own, as Rod likes to say (although he words it differently).

on 1/19/2007 7:49 AM, Francesca Skelton at fskelton@... wrote:

The capsules equal 5 to 15 glasses of red wine (true that it's vague). The cost is much less than what you mention below. (About $240 for a 5 month supply).

More on this later when I have the chance to reply in more detail.

on 1/18/2007 9:27 PM, Dowling at christopher.a.dowling@... wrote:

Francesca-

The study regarding other components of red wine

addressed vascular smooth muscle proliferation only,

while studies of resveratrol (RSV) have revealed

a panoply of beneficial metabolic effects as

well as experimental animal life extension.

Additionally, just how much RSV is present

in a Longevinex capsule? It's not clear to

me from the list of ingredients.

Even if there were 100 mg RSV per Longevinex

capsule, and one got the " bargain " pricing,

it would roughly cost me (~60 kg) $1,000/year

to achieve the 5 mg/kg level.

At the highest pricing has listed for

the 99% purity, peer reviewed animal study

tested product, I'd be paying approximately

$440/year. I already own more than one

freezer, and have plenty of space....

On 1/18/07, Antonik Wakfer <paul@...> wrote:

Note from Francesca: A recent study posted here claimed that reservatrol is NOT the main ingredient in wine that benefits longevity. Also another study that claims that reservatrol gives no further benefit to those already on CR. That said, I am myself on a trial of it purchased from the site posted by Maco a few weeks back. I have been taking it for 2 months and notice no difference in my energy level or otherwise. Maco's site is purityproducts.com <http://purityproducts.com> and the capsules do not need refrigeration orany special handling unlike the bulk purchase that is proposing below. It also has special " deals " at the site and I paid a reasonable price.

Here is 's post:

Notice of Joint Bulk Purchase of >99% Resveratrol

Participants are being sought for a joint bulk purchase of >99% pure

fully synthetic trans-resveratrol from the exact same company (Orchid

Chemicals and Pharmaceuticals Ltd of Chennai, India) that supplied the

resveratrol used in the last two major published mouse feeding studies

http://pmid.us/17086191 http://pmid.us/17112576. In these studies

trans-resveratrol, at human equivalent daily dosages of 5 and 50 mg/kg

respectively, was shown to have major beneficial effects as a calorie

restriction mimetic, and on enhanced mitochondrial activity resulting

in more energy and stamina respectively. The pure synthetic has the

advantage that it is completely free from plant contaminants which may

have negative effects, while being exactly the same chemical as occurs

in nature in red wine (among other sources). In order to obtain a

supply of trans-resveratrol for myself and other interested parties, I

am seeking others to join me in a large bulk purchase so that together

we may get the far lower price per gram that the supplier will give

for a large order. I have already successfully received and

distributed to the initial joint purchase participants 4 kg from

Orchid which is in the process of producing a large new batch to be

ready by mid March 2007. This notice is for the purpose of increasing

the amount that will be ordered at that time, if anyone should be

interested.

Here are the terms of this add-on commitment for new joint bulk

purchase participants.

Terms and Conditions of Joint Bulk Purchase as of Jan 18, 2007

Pricing

100 grams @ $4.00 per gram,

200 grams @ $3.65 per gram,

300 grams @ $3.40 per gram,

400 grams @ $3.25 per gram,

500 grams @ $3.15 per gram.

Packaging

All purchases are packaged in 50 or 100 gm amounts in polypropylene

(PP) zip-lock bags with all air expelled before the bag is closed. PP

bags are much more moisture and air proof than are polyethylene (PE)

bags (the standard that one gets at the supermarket). Each PP bag is

placed in a zip-lock PE sandwich bag for added protection. Multiple

bags are then placed into a bubble envelope which is then placed

inside a USPS flat rate priority mail envelope for shipments of 200

grams or less and a priority box for more than that. (For those

outside the US things will be done a little differently as appropriate

to your import needs.)

Storage, handling and Dosage

If the bags are kept in a freezer (all processes are slower at a lower

temperature), and inside a light proof container (dark bottle or HDPE

container), then research, reading and discussions with others

suggests that there will be little degradation over a period of 2

years. The mice researchers stated nothing about storage in nitrogen

during the experiment and most of the storage time was in a

refrigerator mixed with chow. During actual usage everyone would be

wise to expel all air from the bag whenever it is reclosed after

getting some out of it.

When you remove some resveratrol from a larger package, only remove

enough to last for, say, ten days or 2 weeks at a time and, when not

in use, keep it in a small PP ziplock bag in a dark bottle in the

refrigerator. Small PP zip-lock bags will be enclosed with every

shipment package for the purpose of keeping this smaller in-use amount

in the refrigerator.

As for dosage, standard dosage increasing procedures for any new

chemical suggests that it will be safest to start at 0.5 mg/kg daily

and double every 2 weeks until you reach at least 5 mg/kg (which is

what Dr Sinclair takes and what I am taking), but this is really

a matter of individual choice and desire for experimentation. With

respect to upper limits of dosage, note that there is no evidence of

toxicity for resveratrol even at a human equivalent dosage of 75 mg/kg

- http://pmid.us/15329443.

Shipping and payment

All prices include priority mail (USPS) shipping to US addresses and a

copy of the Certificate of Analysis (COA) of the product.

Insurance of package costs extra.

Out of US shipping incurs a $25 surcharge (only $15 to Canada) with no

customs entry guarantees.

Email me your full legal name, physical and postal addresses, phone

number and amount desired.

Be prepared to pay in advance by check or money order in early March

when the next order with Orchid will need to be placed and prepaid,

since this is a joint bulk purchase and must be prepaid.

I will email you when I need prepayment in March.

Responsibility for Loss

Everyone should be aware that although all joint purchasers received

their allotted share of the first partial shipment, there is always

some possibility that an entire future shipment, or merely a shipment

to a particular joint purchaser, will be lost. Although as the

coordinator of this prepaid joint bulk purchase I promise to do

everything that I possibly can to prevent any such loss, I do not bear

any responsibility for refunding any money in the case of any such loss.

-- Wakfer

MoreLife for the rational - http://morelife.org

Reality based tools for more life in quantity and quality

The Self-Sovereign Individual Project - http://selfsip.org

Rational freedom by self-sovereignty & social contracting