Resveratrol article in Cell

[Guest guest]

Happy New Year to everyone,

This semi-review/summary article on resveratrol and its putative

mechanisms in mice came out just before the holidays.

Cheers,

-Will

Resveratrol Improves Mitochondrial Function and Protects against

Metabolic Disease by Activating SIRT1 and PGC-1 & #945;, Cell, Volume 127, Issue

6, 15 December 2006, Pages 1109-1122

Marie Lagouge8, 1, Carmen Argmann8, 1, Zachary Gerhart-Hines2, Hamid

Meziane3, Carles Lerin2, Frederic Daussin4, Nadia Messadeq3, Jill Milne5 et

al. Resveratrol increases life span in lower organisms by activating the

NAD+-dependent histone deacetylase Sirt1. Studies by Lagouge et al. (2006)

and Baur et al. (2006) now show that resveratrol promotes longevity and

improves glucose homeostasis in mice by stimulating the Sirt1-mediated

deacetylation of the transcriptional coactivator PGC-1 & #945;.

Jewell, Ph.D.

Campus Mass Spectrometry Facilities

UC

cmsf.ucdavis.edu