CR + minerals for bones

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Hi All,

See the below on CR. Receiving an adequate level of vitamin D, calcium, zinc

and

copper seems to be a good idea in CRers for maintaining bones if not receiving

adequate exercise levels.

Clin Nutr Abstracts Presented at the 27th ESPEN Congress, Page 60, P118

THE EFFECTS OF DIETARY VITAMIN D AND CALCIUM ON BONE LOSS CAUSED BY DISUSE IN

MALNOURISHED RATS

Y. Kawano, S. Miki, S. Kishimoto, Y. Kondo, A. Momii

Rationale: Decreased diet intake and physical

inactivity are both frequently seen in elderly

people and lead to bone mass loss. Although

vitamin D (VD) and Ca are key nutrients for bone

metabolism, the effects of their supplementation

on osteoporosis caused by physical inactivity and

malnutrition have not been well-investigated.

Hence, we examined the effects of VD and Ca on

bone metabolism in rat models of disuse syndrome

with malnutrition.

Methods: SD rats were divided into 5 groups;

normal ad lib (NOR) or 50% diet-restricted (DR)

groups fed AIN-93G, other 3 groups fed different

liquid diets with diverse nutrient contents (Ca/VD/

Zn/Cu in 100 kcal—HiCD: 94 mg/2 mg/2 mg/0.1 mg;

MidCD: 65 mg/0.5 mg/0.2 mg/0.03 mg; LoCD:

60 mg/0.35 mg/0.1 mg/0.01 mg) at a 50% diet re-striction

based on calorie requirements. The

experiment lasted for 22 days. Rats in 4 groups

under diet restriction were subjected to unloaded

hindlimbs (UHL) from day 7. Blood and urine

samples were collected to evaluate nutritional

status and bone metabolism. Femora were ana-lyzed

with a pQTC device (LaTheta LCT-100, Aloka,

Tokyo).

Results: Compared to NOR, body weight (BW),

femora weight, and albumin level were lower in

DR, suggesting that they were malnourished.

Elevation of urinary deoxypyridinoline (DPD), and

reduction of bone density (BD) in femora were also

observed in DR. Compared with HiCD, urinary Pi and

DPD increased in MidCD and LoCD (MidCD 189%,

P<0.01, LoCD 267%, P<0.01; MidCD 125%, N.S.,

LoCD 144%, P<0.01, respectively). BD was higher in

HiCD compared to LoCD (P<0.05).

Conclusions: Rats with UHL under diet restriction

demonstrated the characteristics of disuse syn-

drome with malnutrition. Increased intake of VD and

Ca with other trace elements may be beneficial for

improving bone metabolism in patients with disuse

syndrome even under malnourished conditions.

Al Pater, PhD; email: old542000@...

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