_Ginger_may_help_prevent_treat_ovarian_cancer

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Diet & Health : Cancer

Last Updated: Jan 3, 2008 - 6:34:42 PM

Ginger may help prevent, treat ovarian cancerBy Liu, Ph.D.Jan 3, 2008 - 6:07:37 PM

THURSDAY JAN 3, 2008 (Foodconsumer.org) -- Ginger extract may be used to prevent and or treat ovarian cancer by interrupting the formation of new blood vessels for cancer cells, suggests a new study published in the Dec. 20, 2007 issue of BMC Complementary and Alternative Medicine.In the study, Rhode from 88th Medical group of - AFB in Ohio and colleagues from National Institutes of Health and University of Michigan in Ann Arbor found a ginger extract preparation significantly inhibited growth of cultured ovarian cancer cells.They also found that among gingerols, 6-shogaol is the most active ginger compound with regard to its inhibition of NF-kB activation as well as secretion of NF-kB regulated gene products namely VEGF and IL-8.Vascular endothelial growth factor or VEGF is a well known pro-angiogenic cytokine known to induce tumor angiogenesis or formation of tumor blood vessels and involved in various stages of avian cancer carcinogenesis or cancer development. The serum level of VEGF is actually an independent prognostic factor for patients with ovarian cancer.Interleukin-8 or IL-8 is a pro-angiogenic factor that affects cancer progression through mitogenic, angiogenic and motogenic effects, according to the researchers. Ovarian cancer patients have been found to carry high levels of IL-8 in their blood, stimulating proliferation of ovarian cancer cells, early in vitro studies showed.According to the researchers, studies have shown ginger root ( Zingiber officinale radix Roscoe) and its polyphenolic compounds such as gingerols and zerumbone have anti-oxidant, anti-inflammatory and anti-carcinogenic activity. Studies have already showed the ginger root and its constituents can inhibit NF-kB activation induced by a variety of agents and down regulate the Nf-kB regulated gene products including VEGF and IL-8.Rhode and team concluded that "Ginger inhibits growth and modulates secretion of angiogenic factors in ovarian cancer cells. The use of dietary agent such as ginger may have potential in the treatment and prevention of ovarian cancer. "Ovarian cancer was expected to be diagnosed in 22,430 women and 15,280 women to die from the disease and complications of treatments for the disease in the United States in 2007, according to the National Cancer Institute.

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