Guest guest Posted March 27, 2007 Report Share Posted March 27, 2007 Hi, Thought I would get involved with this discussion. My husband was on Gleevec since July 2004 and got a log 3 reduction within the first year. But he, too, had terrible side effects with Gleevec. December 2005 his oncologist, Dr. Paquette, at UCLA took him off the Gleevec entirely. Three months later he had minimal recurrance, log 2 reduction, By the end of 6 months, he was at a log 1 reduction and then when Sprycel was approved he immediately began Sprycel. He is now on a dosage of 70 mg per day and he in almost back to a log 3 reduction. Maybe that's now what they recommend at MD , but that's what he is doing and the side effects from the Sprycel are much, much less. wife to diag 7/20/04 immediately put on Gleevec 400mg off Gleevec 12/05 on Sprycel 6/06 100 At 06:34 PM 3/26/2007, Terry Whelan intelligently penned >Hello everyone! > >My name is Terry Whelan and I live in Mount Pearl, Newfoundland and >Labrador, Canada. >I am 59 and was diagnosed in Oct. of 2002. >I went the normal route of Hydrea and Interferon, and of course paid >the price in side effects. >I have been on Gleevec for about 2 years and although I am not getting >bad results my Dr. would like me to try AMN107 which is in clinical >trials. >I am all for it, I think. 8-) >I know other CMLers did the same for all of us on Gleevec and would >like to try and do my part. >I have the consent form and am looking it over and talking to my >family and my family Dr. >The only problem I can see is that in a previous trial theree were 7 >fatalities, 3 of which were not attributed to the trial and 4 that >were inconclusive as to the part paid. >Here in Canada there will be 60 participants from 20 centers.I will >ask tomorrow about the number of participants in the previous study, >but if it was around the same number that seems like more that 10% >fatalities. >I guess I am using all of you as my sounding board, and asking if any >of you have nowledge of AMN107 and if you do please let me know what >you have experienced or heard. >Thanks for any help you can offer. >Best regards and lets keep going until CML is not such a dread disease. >Terry > > > > > Quote Link to comment Share on other sites More sharing options...
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