RX increase

[Guest guest]

My oncologist called me today about my PCR and FISH test. My FISH test was

negative and my PCR was:

Results: Positive Major breakpoint (0.006%)

Interpretation=this result is consistent with minimal residual disease

BCR_ABL transcript

Major a13a2=.006%

Major e14a2=not detected

Major combined=.006%

Minor e1a2=not detected

When I shared this report with this group a few weeks ago, everyone says

this was a good report. However, my oncologist wants to increase my Gleevec

to 600 MG. Does this match protocol with these readings? I thought she

would just continue me on my 400mg. I've been able to tolerate the side

effects at 400, but really scared what 600 will do.

Thanks

[Guest guest]

Hi Barbara,

I would ask your doctor why she wants to increase your dose at this

point. What is her goal and does she have any evidence to suggest

that your long term survival will improve with the increased dose.

I have not seen anything to indicate that being PCRU has any

advantage over having a 3 log reduction so if it were me personally,

I wouldn't want to risk getting more side effects for nothing in

return.

Take care,

Tracey

>

> My oncologist called me today about my PCR and FISH test. My FISH

test was

> negative and my PCR was:

>

>

>

> Results: Positive Major breakpoint (0.006%)

>

> Interpretation=this result is consistent with minimal residual

disease

>

>

>

> BCR_ABL transcript

>

> Major a13a2=.006%

>

> Major e14a2=not detected

>

> Major combined=.006%

>

> Minor e1a2=not detected

>

>

>

> When I shared this report with this group a few weeks ago, everyone

says

> this was a good report. However, my oncologist wants to increase

my Gleevec

> to 600 MG. Does this match protocol with these readings? I

thought she

> would just continue me on my 400mg. I've been able to tolerate the

side

> effects at 400, but really scared what 600 will do.

>

> Thanks

>

>

>

>