Re: Tasigna (AMN-107) Approval? Skip

[Guest guest]

Hi Skip,

I haven't seen much on the list regarding the side affects of AMN107. But

maybe I missed it during a period where I wasn't able to read.

I heard initially from the doctors locally here that they were less than

Gleevec?

Is that true and what is the side affects of AMN107 is there a list

somewhere?

ez

[Guest guest]

Hi Liza

well as you know everyone's experience is different

but as far as I am concerned AMN107 is a blessing

hardly any effects at all, bit of itching etc

sometimes a sore back.. but all in all great

best thing since sliced bread as for me that is..

it is supposed to be 5 time stronger than gleevec

yet I had tons of problem with gleevec..

Hope this helps

Skipd

--- ez <lmartinez@...> wrote:

> Hi Skip,

>

> I haven't seen much on the list regarding the side

> affects of AMN107. But

> maybe I missed it during a period where I wasn't

> able to read.

>

> I heard initially from the doctors locally here that

> they were less than

> Gleevec?

>

> Is that true and what is the side affects of AMN107

> is there a list

> somewhere?

>

>

>

> ez

>

>

>

>

>

> [Non-text portions of this message have been

> removed]

>

>

SkipD

Dx'ed Dec 1978

on Myleran(busulfan) 26 yrs

on Hydroxyurea for about 1 year

on Gleevec for approx 1.5 years

on AMN107(Nilotinib) to now

________________________________________________________________________________\

____

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[Guest guest]

The side effect profile for AMN-107 is both similar and different to

Gleevec. To say its safer is a bit of stretch to conclude.

AMN107 is a modified version of Gleevec to bind better to the BCR-ABL

protein and focus more of its activity vs. the BCR-ABL structure.

The follow-up for AMN-107 is not as long and its really not tested in

the same population since the people in the study were resistant to

Gleevec. Thus a direct comparison may not be fair.

The results so far show that for the many of the standard Gleevec

side effect (rash, nausea, fatigue, cramping, etc) the serious Grade

3/4 and overall side effects profile for AMN107 is basically the same

as Gleevec.

The amount of peripheral edema in people taking AMN107 may be less

than seen in Gleevec. Also, almost none of the people who had a

serious side effect while taking Gleevec experienced the same side

effect on AMN-107.

Unexpectedly, serious lab test abnormalities indicating liver and

kidney toxicity was several times higher in the people taking AMN107

as compared to the experience with Gleevec. Something that had never

been reported with Gleevec was serious lab test abnormalites of the

function of the pancreas in the AMN107 group (>10%). Evidently, most

of the people experiencing these abnormalities did not have any

physical complaints but they had to stop taking AMN107 once the

abnormal test was observed. Also, a few people taking AMN107

experienced some cardiac problems so their may need to be greater

precaution with regard to taking AMN107 in people with a heart

problem history.

[Guest guest]

,

Thanks for paying attention to your ol man. I am following this very close

myself. It is due to come out late this summer/fall, final trial. I guess from

what I see it would not be a choice, it would be perhaps be another option

should sprycel decide to take a shit. As you read it is not a cure and same side

effects. I guess if you got to be sick it is nice to know there seems to always

be another option. I think I'll be jamming along for the the next twenty years

this way.

Love DAD

<timothyfarley16@...> wrote: The

side effect profile for AMN-107 is both similar and different to

Gleevec. To say its safer is a bit of stretch to conclude.

AMN107 is a modified version of Gleevec to bind better to the BCR-ABL

protein and focus more of its activity vs. the BCR-ABL structure.

The follow-up for AMN-107 is not as long and its really not tested in

the same population since the people in the study were resistant to

Gleevec. Thus a direct comparison may not be fair.

The results so far show that for the many of the standard Gleevec

side effect (rash, nausea, fatigue, cramping, etc) the serious Grade

3/4 and overall side effects profile for AMN107 is basically the same

as Gleevec.

The amount of peripheral edema in people taking AMN107 may be less

than seen in Gleevec. Also, almost none of the people who had a

serious side effect while taking Gleevec experienced the same side

effect on AMN-107.

Unexpectedly, serious lab test abnormalities indicating liver and

kidney toxicity was several times higher in the people taking AMN107

as compared to the experience with Gleevec. Something that had never

been reported with Gleevec was serious lab test abnormalites of the

function of the pancreas in the AMN107 group (>10%). Evidently, most

of the people experiencing these abnormalities did not have any

physical complaints but they had to stop taking AMN107 once the

abnormal test was observed. Also, a few people taking AMN107

experienced some cardiac problems so their may need to be greater

precaution with regard to taking AMN107 in people with a heart

problem history.

---------------------------------

Moody friends. Drama queens. Your life? Nope! - their life, your story.

Play Sims Stories at Games.

[Guest guest]

not sure how you read my e-mail, but I used me.. as

the operative word. I never try to say one is better

than the other. I never try to get to technical, I

just give my own experience. How medication works on

me.. I leave everyone to their own experince. If

asked I will respond but never volunteer any

information, only on my web site which shows my counts

and how I respond.

SkipD

--- <timothyfarley16@...> wrote:

> The side effect profile for AMN-107 is both similar

> and different to

> Gleevec. To say its safer is a bit of stretch to

> conclude.

>

> AMN107 is a modified version of Gleevec to bind

> better to the BCR-ABL

> protein and focus more of its activity vs. the

> BCR-ABL structure.

>

> The follow-up for AMN-107 is not as long and its

> really not tested in

> the same population since the people in the study

> were resistant to

> Gleevec. Thus a direct comparison may not be fair.

>

> The results so far show that for the many of the

> standard Gleevec

> side effect (rash, nausea, fatigue, cramping, etc)

> the serious Grade

> 3/4 and overall side effects profile for AMN107 is

> basically the same

> as Gleevec.

>

> The amount of peripheral edema in people taking

> AMN107 may be less

> than seen in Gleevec. Also, almost none of the

> people who had a

> serious side effect while taking Gleevec experienced

> the same side

> effect on AMN-107.

>

> Unexpectedly, serious lab test abnormalities

> indicating liver and

> kidney toxicity was several times higher in the

> people taking AMN107

> as compared to the experience with Gleevec.

> Something that had never

> been reported with Gleevec was serious lab test

> abnormalites of the

> function of the pancreas in the AMN107 group (>10%).

> Evidently, most

> of the people experiencing these abnormalities did

> not have any

> physical complaints but they had to stop taking

> AMN107 once the

> abnormal test was observed. Also, a few people

> taking AMN107

> experienced some cardiac problems so their may need

> to be greater

> precaution with regard to taking AMN107 in people

> with a heart

> problem history.

>

>

SkipD

Dx'ed Dec 1978

on Myleran(busulfan) 26 yrs

on Hydroxyurea for about 1 year

on Gleevec for approx 1.5 years

on AMN107(Nilotinib) to now

________________________________________________________________________________\

____

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