Re: Coumadin & Gleevec

[Guest guest]

Dear Kathie

I have been on Coumadin since 2000 due to two pulmonary embolisms that I had.

I was diagnoised with CML June 06 and am on 400mgs of Gleevec. I take 5 mgs

of coumadin every night except for Tues & Thurs. Then I only take 21/2 mgs. I

am monitored by my internist and oncologist. I have blood tests every 4 wks to

make sure the coumadin is at the right level. The only thing I have found is

that I am colder than I ever was. I am also 74 years old. I guess the

combination of Coumadin and Gleevec is the reason. Other than that I seem to be

okay.

Hope this helps.

Ceil

NYC<BR><BR><BR>**************************************<BR> See what's free at

http://www.aol.com.</HTML>

[Guest guest]

Hi Kathy,

I have been on Coumadin since 1991 as the result of an artificial mechanical

aortic valve and have been on Gleevec since 2001.

My Gleevec dose is 400 mg daily and my Coumadin dose varies between 4 and 5

mg daily. Since Gleevec, my INR level fluctuates quite a bit. I need to

check it every 2-3 weeks and make a small adjustment to the dose.

Zavie

Zavie (age 68)

67 Shoreham Avenue

Ottawa, Canada, dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 309-296-0807

Cell: 613-202-0204

ID: zaviem

[ ] Coumadin & Gleevec

Dear Listmates:

I am writing to seek the counsel of any of you who have had bouts of

atrial fib or who have had to take blood thinners. I was just

released from the hospital after a bout with atrial fib. My heart

has returned to sinus rhythm on its own accord, but now the

hospitalist has recommended that I take a low dose (2 mgs) of

Coumadin to guard against possible clots forming should I return to

atrial fib. Everything I have read says that Coumadin should not be

taken with Gleevec as Gleevec accelerates the effects of Coumadin.

And I had a gastro bleed last year that put me in the hospital

needing two units of packed red blood cells. As a result my dose of

Gleevec was lowered from 800 mgs. to 600 mgs.

Is there anyone out there on Coumadin. If so would you mind sharing

your dosage, how long you have been on the drug, how often your INR

levels are monitored, and what if any side effects you have

experienced.

In addition to taking 600 mgs. of Gleevec I also take 40,000 units of

ProCrit weekly. I have been zero by PCR since July of 2005, having

been diagnosed 12/03.

Please feel free to respond to me off list if you prefer.

Thanks for the help.

Kathie formerly in Kentucky, now in Naples.

[Guest guest]

Dear Kathie,

I've been on Coumadin for a year, since I had a pulmonary embolism

last April. I'm on what I think is a pretty high dose: 12.5 mg. 5x

a week and 15 mg. 2x a week. I have my INR done about every three

weeks (once I was stable, it had been once a month, then after my

number went low and my dosage was increased, it was once a week, now

once every three weeks).

I don't think I have any side effects from the Coumadin (other than

the obvious -- bleeding excessively when I cut myself).

I'm glad you're out of the hospital (what an awful place to be) and

hope you're well.

Warm regards.

>

> Dear Listmates:

>

> I am writing to seek the counsel of any of you who have had bouts

of

> atrial fib or who have had to take blood thinners. I was just

> released from the hospital after a bout with atrial fib. My heart

> has returned to sinus rhythm on its own accord, but now the

> hospitalist has recommended that I take a low dose (2 mgs) of

> Coumadin to guard against possible clots forming should I return

to

> atrial fib. Everything I have read says that Coumadin should not

be

> taken with Gleevec as Gleevec accelerates the effects of Coumadin.

> And I had a gastro bleed last year that put me in the hospital

> needing two units of packed red blood cells. As a result my dose

of

> Gleevec was lowered from 800 mgs. to 600 mgs.

>

> Is there anyone out there on Coumadin. If so would you mind

sharing

> your dosage, how long you have been on the drug, how often your

INR

> levels are monitored, and what if any side effects you have

> experienced.

>

> In addition to taking 600 mgs. of Gleevec I also take 40,000 units

of

> ProCrit weekly. I have been zero by PCR since July of 2005,

having

> been diagnosed 12/03.

>

> Please feel free to respond to me off list if you prefer.

>

> Thanks for the help.

>

> Kathie formerly in Kentucky, now in Naples.

>

[Guest guest]

Hi,

I wanted to ask if you think that your embolism and Kathies gastro

bleed and heart problem were a result of the Gleevec or did your

doctors think that these problems were totally seperate to you taking

gleevec?

Hope you are well now.

Thanks

Bill

> >

> > Dear Listmates:

> >

> > I am writing to seek the counsel of any of you who have had bouts

> of

> > atrial fib or who have had to take blood thinners. I was just

> > released from the hospital after a bout with atrial fib. My

heart

> > has returned to sinus rhythm on its own accord, but now the

> > hospitalist has recommended that I take a low dose (2 mgs) of

> > Coumadin to guard against possible clots forming should I return

> to

> > atrial fib. Everything I have read says that Coumadin should not

> be

> > taken with Gleevec as Gleevec accelerates the effects of

Coumadin.

> > And I had a gastro bleed last year that put me in the hospital

> > needing two units of packed red blood cells. As a result my dose

> of

> > Gleevec was lowered from 800 mgs. to 600 mgs.

> >

> > Is there anyone out there on Coumadin. If so would you mind

> sharing

> > your dosage, how long you have been on the drug, how often your

> INR

> > levels are monitored, and what if any side effects you have

> > experienced.

> >

> > In addition to taking 600 mgs. of Gleevec I also take 40,000

units

> of

> > ProCrit weekly. I have been zero by PCR since July of 2005,

> having

> > been diagnosed 12/03.

> >

> > Please feel free to respond to me off list if you prefer.

> >

> > Thanks for the help.

> >

> > Kathie formerly in Kentucky, now in Naples.

> >

>

[Guest guest]

Hi, Bill. My primary care doctor thought that it might be related

to CML or Gleevec. My oncologist/hematologist didn't think so; I

would tend to defer to him. Have a nice weekend.

> > >

> > > Dear Listmates:

> > >

> > > I am writing to seek the counsel of any of you who have had

bouts

> > of

> > > atrial fib or who have had to take blood thinners. I was just

> > > released from the hospital after a bout with atrial fib. My

> heart

> > > has returned to sinus rhythm on its own accord, but now the

> > > hospitalist has recommended that I take a low dose (2 mgs) of

> > > Coumadin to guard against possible clots forming should I

return

> > to

> > > atrial fib. Everything I have read says that Coumadin should

not

> > be

> > > taken with Gleevec as Gleevec accelerates the effects of

> Coumadin.

> > > And I had a gastro bleed last year that put me in the hospital

> > > needing two units of packed red blood cells. As a result my

dose

> > of

> > > Gleevec was lowered from 800 mgs. to 600 mgs.

> > >

> > > Is there anyone out there on Coumadin. If so would you mind

> > sharing

> > > your dosage, how long you have been on the drug, how often

your

> > INR

> > > levels are monitored, and what if any side effects you have

> > > experienced.

> > >

> > > In addition to taking 600 mgs. of Gleevec I also take 40,000

> units

> > of

> > > ProCrit weekly. I have been zero by PCR since July of 2005,

> > having

> > > been diagnosed 12/03.

> > >

> > > Please feel free to respond to me off list if you prefer.

> > >

> > > Thanks for the help.

> > >

> > > Kathie formerly in Kentucky, now in Naples.

> > >

> >

>