RE : Re: Coumadin & Gleevec

[Guest guest]

Hi,

I am very tired and I have no energy. I asked my doctor

(haematologist) and he said that my condition is related to my heart condition.

I had some episode of atrial fibrillation. I asked my cardiologist and he said

that my heart is in good condition. The ejection fraction evaluated by

ultrasound scan, is 65% (very good).

Another cardiologist said to me that some patients don't tolerate

Rythmol (medication to control atrial fibrillation) . In August 2006, one

cardiologist doubled my prescription of Rythmol to 600mg (this is the maximum

prescription for this medicament). In August 2006, I had three episodes of

atrial fibrillation. That's the reason why the cardiologist

increased the Rythmol.

According to the computer, there is no evidence of interaction

between Gleevec and Rythmol, between Gleevec and Coumadin, and,

between Gleevec and Monocor.

I found some patients taking Coumadin but I didn't find a

patient taking Rythmol. However I knew some patients having some

problems with the combination Coumadin + Gleevec. The Gleevec interact with

Coumadin by increasing momentarily the INR rate for two or three days. I take

3,5 mg of Coumadin.The INR rate is normally controlled between 2,0 and 2,5. For

some days, the INR rate jump to 3,5 and come back to 2,5.

I met a nephrologist for my kidneys because my creatinine

level is high (120-130 for a maximum of 110). So I am worried about

the interaction of Gleevec with my kidneys. My doctor said to me

to drink more water. There is no evidence of interaction of Gleevec in my case.

In the year 2002, my creatinine level increased after I took Vioxx and seem to

stabilize since that year. When I took Vioxx, I started to have hypertension.

With regards,

Gilles (Montreal, Canada, diagx June 2005)

doveh12 <deh12@...> a écrit :

Hi, Bill. My primary care doctor thought that it might be related

to CML or Gleevec. My oncologist/hematologist didn't think so; I

would tend to defer to him. Have a nice weekend.

> > >

> > > Dear Listmates:

> > >

> > > I am writing to seek the counsel of any of you who have had

bouts

> > of

> > > atrial fib or who have had to take blood thinners. I was just

> > > released from the hospital after a bout with atrial fib. My

> heart

> > > has returned to sinus rhythm on its own accord, but now the

> > > hospitalist has recommended that I take a low dose (2 mgs) of

> > > Coumadin to guard against possible clots forming should I

return

> > to

> > > atrial fib. Everything I have read says that Coumadin should

not

> > be

> > > taken with Gleevec as Gleevec accelerates the effects of

> Coumadin.

> > > And I had a gastro bleed last year that put me in the hospital

> > > needing two units of packed red blood cells. As a result my

dose

> > of

> > > Gleevec was lowered from 800 mgs. to 600 mgs.

> > >

> > > Is there anyone out there on Coumadin. If so would you mind

> > sharing

> > > your dosage, how long you have been on the drug, how often

your

> > INR

> > > levels are monitored, and what if any side effects you have

> > > experienced.

> > >

> > > In addition to taking 600 mgs. of Gleevec I also take 40,000

> units

> > of

> > > ProCrit weekly. I have been zero by PCR since July of 2005,

> > having

> > > been diagnosed 12/03.

> > >

> > > Please feel free to respond to me off list if you prefer.

> > >

> > > Thanks for the help.

> > >

> > > Kathie formerly in Kentucky, now in Naples.

> > >

> >

>

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