Re: Outcome of Gleevec and LIVER TESTING

[Guest guest]

Hi ,

You don't mention how high 's liver enzymes are but if they're

more than 5 times higher than the upper limit of normal then it is

standard protocol to stop the Gleevec and wait for the counts to come

down. If it is the Gleevec that is causing the toxicity, he has to

stop taking it before it permanently damages his liver so don't worry

about him not taking the Gleevec for a few days. Right now, his

liver is a more pressing issue than the CML is.

Did mention to the doctor that he had been drinking alcohol and

taking Tylenol before this happened? Liver enzymes can go up and go

up VERY fast once its exposed to a toxic level of drugs (which the

combination of Gleevec, alcohol and Tylenol could easily cause) so

it's not at all surprising that this could happen " all of a sudden "

when things were going seemingly well previously.

For some people who couldn't get their liver counts under control

while on Gleevec, Sprycel was an option that was successful so that's

probably why the doctor mentioned it.

Let us know when he gets his results back but if he lays off the

alcohol and the Tylenol, I expect that things will settle down so try

not to worry.

Take care,

Tracey

[Guest guest]

Thanks, . He only drank and took Tylenol last Saturday and these tests

were run yesterday (Tues). So, that is 3 days in between where he had

nothing in his system. is going to call and get further clarification

on the liver counts exactly, so we can gauge how high they are, etc. All we

know is that his doctor was very concerned, it's not like the counts were

slightly off.

Thanks again for your insights,

>From: " Tracey " <traceyincanada@...>

>Reply-

>

>Subject: [ ] Re: Outcome of Gleevec and LIVER TESTING

>Date: Wed, 23 May 2007 22:10:21 -0000

>

>Hi ,

>

>You don't mention how high 's liver enzymes are but if they're

>more than 5 times higher than the upper limit of normal then it is

>standard protocol to stop the Gleevec and wait for the counts to come

>down. If it is the Gleevec that is causing the toxicity, he has to

>stop taking it before it permanently damages his liver so don't worry

>about him not taking the Gleevec for a few days. Right now, his

>liver is a more pressing issue than the CML is.

>

>Did mention to the doctor that he had been drinking alcohol and

>taking Tylenol before this happened? Liver enzymes can go up and go

>up VERY fast once its exposed to a toxic level of drugs (which the

>combination of Gleevec, alcohol and Tylenol could easily cause) so

>it's not at all surprising that this could happen " all of a sudden "

>when things were going seemingly well previously.

>

>For some people who couldn't get their liver counts under control

>while on Gleevec, Sprycel was an option that was successful so that's

>probably why the doctor mentioned it.

>

>Let us know when he gets his results back but if he lays off the

>alcohol and the Tylenol, I expect that things will settle down so try

>not to worry.

>

>Take care,

>Tracey

>

>

>

>

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[Guest guest]

My liver counts have been so far (2 yrs 2 months since dx) very normal, but

if I drink more than a small beer or a glass of wine I feel pretty bad for a

day or two. Same thing if I drink little but every day over a week or so.

While on my last vacation in France (I am French but live in the US), I did

enjoy in moderation Paris food and wines in restaurants and family parties

(no more than one glass), and I felt out of it for a few days afterwards

(tired, slight nausea, headache). But I got a blood test the day after I got

back to California and my liver counts were as usual, very good. I think the

effects of gleevec are complex and this can be involving other organs than

liver. I just avoid alcohol beside a glass a few time a year on special

occasions.

Marcos.

On 5/23/07, Tracey <traceyincanada@...> wrote:

>

> Hi ,

>

> You don't mention how high 's liver enzymes are but if they're

> more than 5 times higher than the upper limit of normal then it is

> standard protocol to stop the Gleevec and wait for the counts to come

> down. If it is the Gleevec that is causing the toxicity, he has to

> stop taking it before it permanently damages his liver so don't worry

> about him not taking the Gleevec for a few days. Right now, his

> liver is a more pressing issue than the CML is.

>

> Did mention to the doctor that he had been drinking alcohol and

> taking Tylenol before this happened? Liver enzymes can go up and go

> up VERY fast once its exposed to a toxic level of drugs (which the

> combination of Gleevec, alcohol and Tylenol could easily cause) so

> it's not at all surprising that this could happen " all of a sudden "

> when things were going seemingly well previously.

>

> For some people who couldn't get their liver counts under control

> while on Gleevec, Sprycel was an option that was successful so that's

> probably why the doctor mentioned it.

>

> Let us know when he gets his results back but if he lays off the

> alcohol and the Tylenol, I expect that things will settle down so try

> not to worry.

>

> Take care,

> Tracey

>

>

>

[Guest guest]

Wow Marcos! You are french AND have had to give up wine?????!!!! So sorry

for you! I guess that is what my husband is learning...he is a wine and beer

lover, but may have to give it up except (as you say) on very special

occasions. Thanks much for your input...

>From: " Marcos Perreau Guimaraes " <montereyunderwater@...>

>Reply-

>

>Subject: Re: [ ] Re: Outcome of Gleevec and LIVER TESTING

>Date: Wed, 23 May 2007 16:13:46 -0700

>

>My liver counts have been so far (2 yrs 2 months since dx) very normal, but

>if I drink more than a small beer or a glass of wine I feel pretty bad for

>a

>day or two. Same thing if I drink little but every day over a week or so.

>While on my last vacation in France (I am French but live in the US), I did

>enjoy in moderation Paris food and wines in restaurants and family parties

>(no more than one glass), and I felt out of it for a few days afterwards

>(tired, slight nausea, headache). But I got a blood test the day after I

>got

>back to California and my liver counts were as usual, very good. I think

>the

>effects of gleevec are complex and this can be involving other organs than

>liver. I just avoid alcohol beside a glass a few time a year on special

>occasions.

>Marcos.

>

>On 5/23/07, Tracey <traceyincanada@...> wrote:

> >

> > Hi ,

> >

> > You don't mention how high 's liver enzymes are but if they're

> > more than 5 times higher than the upper limit of normal then it is

> > standard protocol to stop the Gleevec and wait for the counts to come

> > down. If it is the Gleevec that is causing the toxicity, he has to

> > stop taking it before it permanently damages his liver so don't worry

> > about him not taking the Gleevec for a few days. Right now, his

> > liver is a more pressing issue than the CML is.

> >

> > Did mention to the doctor that he had been drinking alcohol and

> > taking Tylenol before this happened? Liver enzymes can go up and go

> > up VERY fast once its exposed to a toxic level of drugs (which the

> > combination of Gleevec, alcohol and Tylenol could easily cause) so

> > it's not at all surprising that this could happen " all of a sudden "

> > when things were going seemingly well previously.

> >

> > For some people who couldn't get their liver counts under control

> > while on Gleevec, Sprycel was an option that was successful so that's

> > probably why the doctor mentioned it.

> >

> > Let us know when he gets his results back but if he lays off the

> > alcohol and the Tylenol, I expect that things will settle down so try

> > not to worry.

> >

> > Take care,

> > Tracey

> >

> >

> >

>

>

>

[Guest guest]

Hi ,

It can sometimes take several weeks to detoxify a liver once it's

been exposed to a toxic mixture so the three days in between 's

drinking and the blood test isn't really much at all.

I hope his counts start to drop now that he's taking a break from the

Gleevec. Let us know how he's doing.

Tracey

>

> Thanks, . He only drank and took Tylenol last Saturday and

these tests

> were run yesterday (Tues). So, that is 3 days in between where he

had

> nothing in his system. is going to call and get further

clarification

> on the liver counts exactly, so we can gauge how high they are,

etc. All we

> know is that his doctor was very concerned, it's not like the

counts were

> slightly off.

>

> Thanks again for your insights,

>

>

>

> >From: " Tracey " <traceyincanada@...>

> >Reply-

> >

> >Subject: [ ] Re: Outcome of Gleevec and LIVER TESTING

> >Date: Wed, 23 May 2007 22:10:21 -0000

> >

> >Hi ,

> >

> >You don't mention how high 's liver enzymes are but if they're

> >more than 5 times higher than the upper limit of normal then it is

> >standard protocol to stop the Gleevec and wait for the counts to

come

> >down. If it is the Gleevec that is causing the toxicity, he has to

> >stop taking it before it permanently damages his liver so don't

worry

> >about him not taking the Gleevec for a few days. Right now, his

> >liver is a more pressing issue than the CML is.

> >

> >Did mention to the doctor that he had been drinking alcohol

and

> >taking Tylenol before this happened? Liver enzymes can go up and

go

> >up VERY fast once its exposed to a toxic level of drugs (which the

> >combination of Gleevec, alcohol and Tylenol could easily cause) so

> >it's not at all surprising that this could happen " all of a sudden "

> >when things were going seemingly well previously.

> >

> >For some people who couldn't get their liver counts under control

> >while on Gleevec, Sprycel was an option that was successful so

that's

> >probably why the doctor mentioned it.

> >

> >Let us know when he gets his results back but if he lays off the

> >alcohol and the Tylenol, I expect that things will settle down so

try

> >not to worry.

> >

> >Take care,

> >Tracey

> >

> >

> >

> >

>

> _________________________________________________________________

> PC Magazine's 2007 editors' choice for best Web mail—award-winning

Windows

> Live Hotmail.

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us & ocid=TXT_TAGHM_migration_HM_mini_pcmag_0507

>