Re: Gleevec Time of Day

May 16, 2007

-

Its funny to get this letter as I am getting back out of bed becasue I am sick

to my stomach. I suffer ALOT of gastritis with my Gleevec (800mg). I have been

in the hospital for it numerous times as well as, I do home IV's once every

couple weeks from the dehydration I get from massive diarrhea and nausea.

I have tried to take it during the day but the overwhelming fatigue and bone

pain caused me to switch to night in which I can sleep through the side effects.

However, there are nights, like tonight, that I am already so nauseated before I

even take the Gleevec, and have no appitate that I just end up taking a light

snack and pay for it. Not always but occasionally. This is awful. I am SO

nauseated, the bile is in my throat and worse if I try ti clear it and I have to

sit up in bed with 4 pillows behind me. Its scary as I have always been someone

afraid of choking so to have all this in my throat and stomach is eerie to me.

I think that what happens to me is not what alot of people go through (I hope),

so your hubby should be fine. I would recommend taking it right after supper

with his meal. I tend to put it off and end up taking it too late most nights

and then I pay for it. Not a smart thing to do!!!

Your hubby should be able to sleep through most of the tiredness part. I wish

him well. He may have to play around with it as far as times go. Best of luck.

35

CML 5\13\05

Gleevec 800mg

Wife and mother of 3 (11,8,6)

S. RN

[ ] Gleevec Time of Day

Hi all---

My husband has been on Gleevec (400mg) since last July when diagnosed,

suffered severe neutropenia for 1 month and was hospitalized for 30 days.

Once we got through that, and his body got used to Gleevec, things started

being on the up and up. He feels really good most days, but after taking

Gleevec with his lunch, gets really tired. This usually occurs around 2PM

every day and then he is really tired the rest of the day. (He is currently

staying home with our 1-yr. old, so that makes him tired, too!). Yes, small

price to pay for otherwise feeling well and being alive!

But--tonight he is trying something different (yikes!). Tonight he is taking

Gleevec about an hour before bed, with cereal or oatmeal, or something

rather " carby " . He is nervous, but started thinking that maybe he could try

taking it at night and sleeping through the tiredness!

I have seen past posts about this subject, and wanted to ask again...how

many of you take Gleevec at night? Have some of you tried and it didnt work

out? About 1-2 times per month my husband doesnt eat enough food with it and

has gotten really nauseated, lasts about 30 minutes. I think that is what he

is scared about.

Any comments would be greatly appreciated...

_________________________________________________________________

Like the way Microsoft Office Outlook works? Youå€¤l love Windows Live

Hotmail.

http://imagine-windowslive.com/hotmail/?locale=en-us & ocid=TXT_TAGHM_migration_HM\

_mini_outlook_0507

May 16, 2007

Hi and ,

I had wicked gastro problems with Gleevec! 8-(

Both massive diarrhea and nausea.

After a lot of experimenting we found Sandostatin for the diarrhea,

I inject this twice a day, sometimes 3 times if needed.

It has given me back some of my life anyway.

I was to the point where I told my Dr. that if nothing could be found

to help I was going to quit the Gleevec, I believe that Quality of

life not Quantity of life is what I want.

For the nausea I take 2 gravol about 1/2 to 1 hour before the Gleevec

which I take at bedtime.

I also find that soda crackers and gingerale both help.

The Gleevec has stopped being effective for me and I am going on a

drug trial for AMN107 which will hopefully work.

Best wishes and I hope some of this info helps.

Regards,

Terry

Dx Oct/02

>

> -

>

> Its funny to get this letter as I am getting back out of bed becasue

I am sick to my stomach. I suffer ALOT of gastritis with my Gleevec

(800mg). I have been in the hospital for it numerous times as well

as, I do home IV's once every couple weeks from the dehydration I get

from massive diarrhea and nausea.

>

> I have tried to take it during the day but the overwhelming fatigue

and bone pain caused me to switch to night in which I can sleep

through the side effects. However, there are nights, like tonight,

that I am already so nauseated before I even take the Gleevec, and

have no appitate that I just end up taking a light snack and pay for

it. Not always but occasionally. This is awful. I am SO nauseated,

the bile is in my throat and worse if I try ti clear it and I have to

sit up in bed with 4 pillows behind me. Its scary as I have always

been someone afraid of choking so to have all this in my throat and

stomach is eerie to me.

> I think that what happens to me is not what alot of people go

through (I hope), so your hubby should be fine. I would recommend

taking it right after supper with his meal. I tend to put it off and

end up taking it too late most nights and then I pay for it. Not a

smart thing to do!!!

>

> Your hubby should be able to sleep through most of the tiredness

part. I wish him well. He may have to play around with it as far as

times go. Best of luck.

>

> 35

> CML 5\13\05

> Gleevec 800mg

> Wife and mother of 3 (11,8,6)

>

> S. RN

>

> [ ] Gleevec Time of Day

>

> Hi all---

> My husband has been on Gleevec (400mg) since last July when diagnosed,

> suffered severe neutropenia for 1 month and was hospitalized for 30

days.

> Once we got through that, and his body got used to Gleevec, things

started

> being on the up and up. He feels really good most days, but after

taking

> Gleevec with his lunch, gets really tired. This usually occurs

around 2PM

> every day and then he is really tired the rest of the day. (He is

currently

> staying home with our 1-yr. old, so that makes him tired, too!).

Yes, small

> price to pay for otherwise feeling well and being alive!

>

> But--tonight he is trying something different (yikes!). Tonight he

is taking

> Gleevec about an hour before bed, with cereal or oatmeal, or something

> rather " carby " . He is nervous, but started thinking that maybe he

could try

> taking it at night and sleeping through the tiredness!

>

> I have seen past posts about this subject, and wanted to ask

again...how

> many of you take Gleevec at night? Have some of you tried and it

didnt work

> out? About 1-2 times per month my husband doesnt eat enough food

with it and

> has gotten really nauseated, lasts about 30 minutes. I think that is

what he

> is scared about.

>

> Any comments would be greatly appreciated...

>

> _________________________________________________________________

> Like the way Microsoft Office Outlook works? Youå€¤l love Windows Live

> Hotmail.

>

http://imagine-windowslive.com/hotmail/?locale=en-us & ocid=TXT_TAGHM_migration_HM\

_mini_outlook_0507

>

May 17, 2007

Hi ,

I am just a lurker on this board, but I wanted to respond to your post about

taking the Gleevec at night. I was diagnosed a year ago in June. I have only

taken my medicine at night (400 mg). I usually take it after dinner, but dinner

for me is anywhere between the hours of 5:30p and 9:00pm. I have had some

problems with diarrea and just a few times with nausea, but never to a point

where I felt I needed something to curb the side effects. There have been a few

times where I forget my Gleevec and have taken it with a bowl of cereal or a

handful of pretzels right before going to bed. Since I'm usually real tired, it

never has affected me in any way.

I feel very blessed as my side effects never seem to last very long and come in

waves. The longest I have had any one side effect has been two weeks. I do

feel tired some days and try to take it easy on those days if I can. There are

also days I experience bone and joint pain (not unlike what I had before being

diagnosed). Again, I take ibuprophen for it and go about my day.

I wish your husband luck. I never took the Gleevec any other time of the day

because I didn't want to risk having some of the side effects throughout the

daytime. But so far I have had great success with it and what little side

effects I've had with it have been well worth it.

Caron

diagnosed June, 2006

44 yrs old

[ ] Gleevec Time of Day

Hi all---

My husband has been on Gleevec (400mg) since last July when diagnosed,

suffered severe neutropenia for 1 month and was hospitalized for 30 days.

Once we got through that, and his body got used to Gleevec, things started

being on the up and up. He feels really good most days, but after taking

Gleevec with his lunch, gets really tired. This usually occurs around 2PM

every day and then he is really tired the rest of the day. (He is currently

staying home with our 1-yr. old, so that makes him tired, too!). Yes, small

price to pay for otherwise feeling well and being alive!

But--tonight he is trying something different (yikes!). Tonight he is taking

Gleevec about an hour before bed, with cereal or oatmeal, or something

rather " carby " . He is nervous, but started thinking that maybe he could try

taking it at night and sleeping through the tiredness!

I have seen past posts about this subject, and wanted to ask again...how

many of you take Gleevec at night? Have some of you tried and it didnt work

out? About 1-2 times per month my husband doesnt eat enough food with it and

has gotten really nauseated, lasts about 30 minutes. I think that is what he

is scared about.

Any comments would be greatly appreciated...

_________________________________________________________________

Like the way Microsoft Office Outlook works? Youå€¤l love Windows Live

Hotmail.

http://imagine-windowslive.com/hotmail/?locale=en-us & ocid=TXT_TAGHM_migration_HM\

_mini_outlook_0507

May 17, 2007

Hi ,

I have been on 400mg for a few weeks now. I always take it at 6:30pm-

7:00pm. I take it in the MIDDLE of my evening meal (eat half, take

the pills, eat the other half).

I have no side effects with it at night. The only side effects I have

are a bit of water retention under my right eye (weird there is none

on the left) But this goes down by mid day and Jaw Ache. But others

have also experienced the Jaw ache and according to my Hemo Dr. This

is common amongst me. I am tired when I wake up but can usually shake

it off a bit by 9am and then I get tired again by 6-7pm (I have a 2

year old as well as a 9 year old and they wear me out right after I

come home also!) But so far I have been able to still work full time

taking my tablets this time of day.

, just a question was your husband hospitalised for the

neutropenia or something else? Why did he stay in for a month?

Hope this helps.

Kind Regards and Best of Luck

Bill in the UK

> >

> > -

> >

> > Its funny to get this letter as I am getting back out of bed

becasue

> I am sick to my stomach. I suffer ALOT of gastritis with my Gleevec

> (800mg). I have been in the hospital for it numerous times as well

> as, I do home IV's once every couple weeks from the dehydration I

get

> from massive diarrhea and nausea.

> >

> > I have tried to take it during the day but the overwhelming

fatigue

> and bone pain caused me to switch to night in which I can sleep

> through the side effects. However, there are nights, like tonight,

> that I am already so nauseated before I even take the Gleevec, and

> have no appitate that I just end up taking a light snack and pay for

> it. Not always but occasionally. This is awful. I am SO

nauseated,

> the bile is in my throat and worse if I try ti clear it and I have

to

> sit up in bed with 4 pillows behind me. Its scary as I have always

> been someone afraid of choking so to have all this in my throat and

> stomach is eerie to me.

> > I think that what happens to me is not what alot of people go

> through (I hope), so your hubby should be fine. I would recommend

> taking it right after supper with his meal. I tend to put it off

and

> end up taking it too late most nights and then I pay for it. Not a

> smart thing to do!!!

> >

> > Your hubby should be able to sleep through most of the tiredness

> part. I wish him well. He may have to play around with it as far

as

> times go. Best of luck.

> >

> > 35

> > CML 5\13\05

> > Gleevec 800mg

> > Wife and mother of 3 (11,8,6)

> >

> > S. RN

> >

> > [ ] Gleevec Time of Day

> >

> > Hi all---

> > My husband has been on Gleevec (400mg) since last July when

diagnosed,

> > suffered severe neutropenia for 1 month and was hospitalized for

30

> days.

> > Once we got through that, and his body got used to Gleevec,

things

> started

> > being on the up and up. He feels really good most days, but after

> taking

> > Gleevec with his lunch, gets really tired. This usually occurs

> around 2PM

> > every day and then he is really tired the rest of the day. (He is

> currently

> > staying home with our 1-yr. old, so that makes him tired, too!).

> Yes, small

> > price to pay for otherwise feeling well and being alive!

> >

> > But--tonight he is trying something different (yikes!). Tonight he

> is taking

> > Gleevec about an hour before bed, with cereal or oatmeal, or

something

> > rather " carby " . He is nervous, but started thinking that maybe he

> could try

> > taking it at night and sleeping through the tiredness!

> >

> > I have seen past posts about this subject, and wanted to ask

> again...how

> > many of you take Gleevec at night? Have some of you tried and it

> didnt work

> > out? About 1-2 times per month my husband doesnt eat enough food

> with it and

> > has gotten really nauseated, lasts about 30 minutes. I think that

is

> what he

> > is scared about.

> >

> > Any comments would be greatly appreciated...

> >

> > _________________________________________________________________

> > Like the way Microsoft Office Outlook works? Youå€¤l love Windows

Live

> > Hotmail.

> >

> http://imagine-windowslive.com/hotmail/?locale=en-

us & ocid=TXT_TAGHM_migration_HM_mini_outlook_0507

> >

May 17, 2007

Hi ,

My husband takes his Gleevec in the morning with breakfast, sandwiching the

pills with bites of food. I have nothing to suggest about taking it at night,

since Jim doesn't do that, but I did want to suggest having your husband include

food with protein and fat when he does take it. My husband is on 800mg, so he

takes 400 with breakfast and 400 with dinner. If the meal is heavy on carbs and

light on protein and fat, he'll become nauseous. As long as he makes sure to

eat enough protein and fat, he's usually feels fine. Everyone is a little

different, so your husband may have to experiment with foods, times of day, etc.

Hope this suggestion helps. Good luck,

Adrienne

Cervera <weez_555@...> wrote:

Hi all---

My husband has been on Gleevec (400mg) since last July when diagnosed,

suffered severe neutropenia for 1 month and was hospitalized for 30 days.

Once we got through that, and his body got used to Gleevec, things started

being on the up and up. He feels really good most days, but after taking

Gleevec with his lunch, gets really tired. This usually occurs around 2PM

every day and then he is really tired the rest of the day. (He is currently

staying home with our 1-yr. old, so that makes him tired, too!). Yes, small

price to pay for otherwise feeling well and being alive!

But--tonight he is trying something different (yikes!). Tonight he is taking

Gleevec about an hour before bed, with cereal or oatmeal, or something

rather " carby " . He is nervous, but started thinking that maybe he could try

taking it at night and sleeping through the tiredness!

I have seen past posts about this subject, and wanted to ask again...how

many of you take Gleevec at night? Have some of you tried and it didnt work

out? About 1-2 times per month my husband doesnt eat enough food with it and

has gotten really nauseated, lasts about 30 minutes. I think that is what he

is scared about.

Any comments would be greatly appreciated...

_________________________________________________________________

Like the way Microsoft Office Outlook works? You’ll love Windows Live

Hotmail.

http://imagine-windowslive.com/hotmail/?locale=en-us & ocid=TXT_TAGHM_migration_HM\

_mini_outlook_0507

May 17, 2007

--- Adrienne <artist934@...> wrote:

> Hi ,

>

> My husband takes his Gleevec in the morning with

> breakfast, sandwiching the pills with bites of food.

> I have nothing to suggest about taking it at night,

> since Jim doesn't do that, but I did want to suggest

> having your husband include food with protein and

> fat when he does take it. My husband is on 800mg,

> so he takes 400 with breakfast and 400 with dinner.

> If the meal is heavy on carbs and light on protein

> and fat, he'll become nauseous. As long as he makes

> sure to eat enough protein and fat, he's usually

> feels fine. Everyone is a little different, so your

> husband may have to experiment with foods, times of

> day, etc. Hope this suggestion helps. Good luck,

>

> Adrienne

>

> Cervera <weez_555@...> wrote:

> Hi all---

> My husband has been on Gleevec (400mg) since last

> July when diagnosed,

> suffered severe neutropenia for 1 month and was

> hospitalized for 30 days.

> Once we got through that, and his body got used to

> Gleevec, things started

> being on the up and up. He feels really good most

> days, but after taking

> Gleevec with his lunch, gets really tired. This

> usually occurs around 2PM

> every day and then he is really tired the rest of

> the day. (He is currently

> staying home with our 1-yr. old, so that makes him

> tired, too!). Yes, small

> price to pay for otherwise feeling well and being

> alive!

>

> But--tonight he is trying something different

> (yikes!). Tonight he is taking

> Gleevec about an hour before bed, with cereal or

> oatmeal, or something

> rather " carby " . He is nervous, but started thinking

> that maybe he could try

> taking it at night and sleeping through the

> tiredness!

>

> I have seen past posts about this subject, and

> wanted to ask again...how

> many of you take Gleevec at night? Have some of you

> tried and it didnt work

> out? About 1-2 times per month my husband doesnt eat

> enough food with it and

> has gotten really nauseated, lasts about 30 minutes.

> I think that is what he

> is scared about.

>

> Any comments would be greatly appreciated...

>

_________________________________________________________________

> Like the way Microsoft Office Outlook works? You’ll

> love Windows Live

> Hotmail.

>

http://imagine-windowslive.com/hotmail/?locale=en-us & ocid=TXT_TAGHM_migration_HM\

_mini_outlook_0507

>

May 17, 2007

I too take it in the MIDDLE of dinner. Eat most of my carb foods on my dish

first and then Gleevec followed by whatever is left on my plate.

If I take it first or right after I feel sick.

I also drink plenty of water to flush the toxicity of the medicine and I

believe this has helped curb the side effects.

I also take magnesium, calcium and potassium at lunch time and this too has

helped tremendously with side effects.

There are others on the lists that use the same regime.

ez

May 17, 2007

thanks for the suggestions...by the way..do you take it while taking your

dinner?? or you take it in between..meaning eat the carbs first..rest then take

gleevec then eat the remaining food...just want to try it so that i can recover

form the feeling of boredness...especially after taking gleevec..i feel so

depressed that i have to experience the side effects practically everyday of my

life..aside from the overwhelming increase in my weight. in just 2 months..i

gained more than 20 pounds!! i can no longer wear my clothes which makes me feel

so bothered...i am so afraid to really get big...as in BIG!! i am starting to

feel uncomfortable since people started to tease me with the way i look

especially so when my face is so fluffy...thanks so much!

ez <lmartinez@...> wrote: I too take it in the MIDDLE

of dinner. Eat most of my carb foods on my dish

first and then Gleevec followed by whatever is left on my plate.

If I take it first or right after I feel sick.

I also drink plenty of water to flush the toxicity of the medicine and I

believe this has helped curb the side effects.

I also take magnesium, calcium and potassium at lunch time and this too has

helped tremendously with side effects.

There are others on the lists that use the same regime.

ez

May 17, 2007

Bill--

My husband was hospitalized for the neutropenia, and was in isolation room

for 30 days. He had developed a minor eye infection which ended up literally

swelling his entire face, and due to the infection and that he literally had

NO WHITE CELLS registering at all, they did not want to risk him developing

other infections. He was literally loaded on antibiotics for all 30 days.

For 2 of those weeks he also was with a 103.5-104 degree fever. We had a doc

at the time that is a well respected onc, but not very familiar with CML.

During that 30-day stay, we switched docs to a doc who currently has 12

patients on Gleevec (Familiar with CML), and we also started seeing

specialists at the City of Hope Cancer Center here in California.

All in all, a hard 30 days, but that was at the beginning of his Gleevec.

Other than fatigue after taking Gleevec, has been quite lucky with the

side affects. He was diagnosed at 33 yrs. old and otherwise is very healthy.

In the very beginning had some joint pain and some headaches that also went

away...they come about 1-2 times a month, pressure behind the eye. When

first diagnosed, I might add, it was because he had a blood clot in his

brain, that's how we found out he had CML. He went through many brain

surgeries, so the CML ended up taking back seat to the neurolical stuff we

had to go through!!! He also thanks God every day for his life, for this

medication and is such a positive person, I know the positivity has alot to

do with his overall well-being.

Good luck to you and to all, and thanks so much for sharing your insights!

Wife of Cervera

Diagnosed 7/06

400mg Gleevec /day

34 yrs. old

>From: " willha46 " <creative@...>

>Reply-

>

>Subject: [ ] Re: Gleevec Time of Day

>Date: Thu, 17 May 2007 12:11:01 -0000

>

>Hi ,

>

>I have been on 400mg for a few weeks now. I always take it at 6:30pm-

>7:00pm. I take it in the MIDDLE of my evening meal (eat half, take

>the pills, eat the other half).

>I have no side effects with it at night. The only side effects I have

>are a bit of water retention under my right eye (weird there is none

>on the left) But this goes down by mid day and Jaw Ache. But others

>have also experienced the Jaw ache and according to my Hemo Dr. This

>is common amongst me. I am tired when I wake up but can usually shake

>it off a bit by 9am and then I get tired again by 6-7pm (I have a 2

>year old as well as a 9 year old and they wear me out right after I

>come home also!) But so far I have been able to still work full time

>taking my tablets this time of day.

>

>, just a question was your husband hospitalised for the

>neutropenia or something else? Why did he stay in for a month?

>

>Hope this helps.

>

>Kind Regards and Best of Luck

>Bill in the UK

>

> > >

> > > -

> > >

> > > Its funny to get this letter as I am getting back out of bed

>becasue

> > I am sick to my stomach. I suffer ALOT of gastritis with my Gleevec

> > (800mg). I have been in the hospital for it numerous times as well

> > as, I do home IV's once every couple weeks from the dehydration I

>get

> > from massive diarrhea and nausea.

> > >

> > > I have tried to take it during the day but the overwhelming

>fatigue

> > and bone pain caused me to switch to night in which I can sleep

> > through the side effects. However, there are nights, like tonight,

> > that I am already so nauseated before I even take the Gleevec, and

> > have no appitate that I just end up taking a light snack and pay for

> > it. Not always but occasionally. This is awful. I am SO

>nauseated,

> > the bile is in my throat and worse if I try ti clear it and I have

>to

> > sit up in bed with 4 pillows behind me. Its scary as I have always

> > been someone afraid of choking so to have all this in my throat and

> > stomach is eerie to me.

> > > I think that what happens to me is not what alot of people go

> > through (I hope), so your hubby should be fine. I would recommend

> > taking it right after supper with his meal. I tend to put it off

>and

> > end up taking it too late most nights and then I pay for it. Not a

> > smart thing to do!!!

> > >

> > > Your hubby should be able to sleep through most of the tiredness

> > part. I wish him well. He may have to play around with it as far

>as

> > times go. Best of luck.

> > >

> > > 35

> > > CML 5\13\05

> > > Gleevec 800mg

> > > Wife and mother of 3 (11,8,6)

> > >

> > > S. RN

> > >

> > > [ ] Gleevec Time of Day

> > >

> > > Hi all---

> > > My husband has been on Gleevec (400mg) since last July when

>diagnosed,

> > > suffered severe neutropenia for 1 month and was hospitalized for

>30

> > days.

> > > Once we got through that, and his body got used to Gleevec,

>things

> > started

> > > being on the up and up. He feels really good most days, but after

> > taking

> > > Gleevec with his lunch, gets really tired. This usually occurs

> > around 2PM

> > > every day and then he is really tired the rest of the day. (He is

> > currently

> > > staying home with our 1-yr. old, so that makes him tired, too!).

> > Yes, small

> > > price to pay for otherwise feeling well and being alive!

> > >

> > > But--tonight he is trying something different (yikes!). Tonight he

> > is taking

> > > Gleevec about an hour before bed, with cereal or oatmeal, or

>something

> > > rather " carby " . He is nervous, but started thinking that maybe he

> > could try

> > > taking it at night and sleeping through the tiredness!

> > >

> > > I have seen past posts about this subject, and wanted to ask

> > again...how

> > > many of you take Gleevec at night? Have some of you tried and it

> > didnt work

> > > out? About 1-2 times per month my husband doesnt eat enough food

> > with it and

> > > has gotten really nauseated, lasts about 30 minutes. I think that

>is

> > what he

> > > is scared about.

> > >

> > > Any comments would be greatly appreciated...

> > >

> > > _________________________________________________________________

> > > Like the way Microsoft Office Outlook works? Youå€¤l love Windows

>Live

> > > Hotmail.

> > >

> > http://imagine-windowslive.com/hotmail/?locale=en-

>us & ocid=TXT_TAGHM_migration_HM_mini_outlook_0507

> > >

May 17, 2007

Thanks to ALL of you responding about the Time of Day post.

My husband did take it last night, with cereal, about 8:30pm. We go to bed

at around 10PM. He was way more tired than he usually is, but he figured it

was fine cuz we were going to bed, and all he was doing was taking it easy

anyway, watching some TV. He normally always always always eats it with tons

of food, yes, lots of protein and fat. Since his diagnosis, we dont eat

dinner, really. That is because he eats so much food for lunch since he

takes Gleevec (about 2PM each day), that we end up eating something small

for dinner. doesnt like the idea of having to eat a huge meal late at

night with Gleevec, so last night he just ate cereal...and knew it might be

risky. All in all, he was very very tired, felt the normal " acidy " feeling

in his stomach for about 30 minutes after taking it, but that was that. Was

there something said before about NOT taking it with milk or something? I

thought I remembered that..?

As I stated, ever since diagnosis, he has become the stay at home parent and

I am the working one. He feels awesome during the day up until he takes

Gleevec, and then he gets knocked out. Because I currently work (3) 12-hr

days, on those 3 days, his parents usually help out with our 1-yr. old son.

We are trying to get to a point where they dont have to help us so much,

(the main reason they do is to be around during 's daily fatigue). So,

our thinking was that if he started taking Gleevec at night, he could escape

the daily fatigue, and handle our son totally on his own.

He is going to expiriment for a couple days now, but changing to the

evenings...just to see what happens. Thank you SO MUCH for all of your

insights--it is so good knowing the support that is available on this forum.

Thanks!

Cervera

>From: melisa adan <lisa_adan@...>

>Reply-

>

>Subject: Re: [ ] Re: Gleevec Time of Day

>Date: Thu, 17 May 2007 16:49:52 +0100 (BST)

>

>thanks for the suggestions...by the way..do you take it while taking your

>dinner?? or you take it in between..meaning eat the carbs first..rest then

>take gleevec then eat the remaining food...just want to try it so that i

>can recover form the feeling of boredness...especially after taking

>gleevec..i feel so depressed that i have to experience the side effects

>practically everyday of my life..aside from the overwhelming increase in my

>weight. in just 2 months..i gained more than 20 pounds!! i can no longer

>wear my clothes which makes me feel so bothered...i am so afraid to really

>get big...as in BIG!! i am starting to feel uncomfortable since people

>started to tease me with the way i look especially so when my face is so

>fluffy...thanks so much!

>

> ez <lmartinez@...> wrote: I too take it in the

>MIDDLE of dinner. Eat most of my carb foods on my dish

>first and then Gleevec followed by whatever is left on my plate.

>

>If I take it first or right after I feel sick.

>

>I also drink plenty of water to flush the toxicity of the medicine and I

>believe this has helped curb the side effects.

>

>I also take magnesium, calcium and potassium at lunch time and this too has

>helped tremendously with side effects.

>

>There are others on the lists that use the same regime.

>

> ez

>

May 17, 2007

Hi-- I also take my Gleevec at night with supper. For me I have to be sure to

have some carbohydrates with it. I guess it's different for everyone....

chris in minn

[ ] Gleevec Time of Day

Hi all---

My husband has been on Gleevec (400mg) since last July when diagnosed,

suffered severe neutropenia for 1 month and was hospitalized for 30 days.

Once we got through that, and his body got used to Gleevec, things started

being on the up and up. He feels really good most days, but after taking

Gleevec with his lunch, gets really tired. This usually occurs around 2PM

every day and then he is really tired the rest of the day. (He is currently

staying home with our 1-yr. old, so that makes him tired, too!). Yes, small

price to pay for otherwise feeling well and being alive!

But--tonight he is trying something different (yikes!). Tonight he is taking

Gleevec about an hour before bed, with cereal or oatmeal, or something

rather " carby " . He is nervous, but started thinking that maybe he could try

taking it at night and sleeping through the tiredness!

I have seen past posts about this subject, and wanted to ask again...how

many of you take Gleevec at night? Have some of you tried and it didnt work

out? About 1-2 times per month my husband doesnt eat enough food with it and

has gotten really nauseated, lasts about 30 minutes. I think that is what he

is scared about.

Any comments would be greatly appreciated...

__________________________________________________________

Like the way Microsoft Office Outlook works? Youå€¤l love Windows Live

Hotmail.

http://imagine-windowslive.com/hotmail/?locale=en-us & ocid=TXT_TAGHM_migration_HM\

_mini_outlook_0507<http://imagine-windowslive.com/hotmail/?locale=en-us & ocid=TXT\

_TAGHM_migration_HM_mini_outlook_0507>

May 17, 2007

Boy this has been a popular topic hasn't it

I take my Gleevec about 2/3rds of the way through my supper meal. I

find this cushions it a bit and reduces the nausea. I never had

nausea at all until they changed it from capsules to pills at which

point the nausea was becoming a real problem.

It took me several months to get used to. Thankfully, it seems to be

controlled now. During the time I spent adjusting though, I became

psychologically conditioned and as a result, I now get nauseous at

the site of certain foods such as pizza even if I haven't taken my

Gleevec yet.

Bill, do you happen to sleep mostly on your right side? I ask this

because I find the edema is always worse in the eye on the side that

I sleep on.

, the issue with the milk isn't about the milk itself, it's

about calcium. We shouldn't take Gleevec within two hours of taking

calcium because the calcium could block or reduce the absorption of

the Gleevec but milk shouldn't be an issue as there's only so much

calcium in a glass of milk.

Take care,

Tracey

dx Jan 2002

May 17, 2007

I take my Gleevec with the evening meal. It seems to work for me. I teach

school full time all day, and feel pretty good. I think if your husband

takes Gleevec at bed time, he's adding an extra meal. He might gain weight. I

get pretty tired at night and sleep through most of the side effects. Why

don't you have him try taking it at dinner?

in NY

400 mg

************************************** See what's free at http://www.aol.com.

May 17, 2007

,

I was just thinking....I was very fatigued in the very beginning and

pre-diagnosis of CML. My Oncologist did notice that my iron was very low and

gave me some iron infusions. I am now on 2 iron tablets a day with the Gleevec.

I notice a HUGE difference in my ability to stay up at night. I used to be

exausted by 8pm every night and now will sometimes make it till midnight if

we're out doing something or something good on the Letterman Show. LOL

Anyway, I know that my case could be that I'm a 44 yr old woman who was low on

Iron due to monthly periods, but you never know.

Blessings to your family,

Caron

Re: [ ] Re: Gleevec Time of Day