RE: PCR When should i worry.

[Guest guest]

Hi ,

Have you tried experimenting with when you take gleevec and with

certain foods?

If you haven't tried already, try to split up your daily dose. It

doesn't matter WHEN you take it, as long as you get in your daily

dose. For me, I have to take gleevec with a decent meal, with

protein, and a carb, and a big glass of water. If I eat anything

greasy with gleevec, I'm in trouble and camping out in the bathroom!

It also helps if I don't lay down soon afterwards. If I do, it

surely comes up the next morning- No food,, just acid. Weird,

weird, but that's just me.

Maybe you could share with us your typical routine on how you take

your pills and with what foods? Some things work better for some t

han others.

Sincerely, Lynn

>

> I have a question ( 2-Part)to throw out to the group. For the last

few

> years,all my test, fish and pcr have come back negative. I am so

> gratefull for that and gleevec is wonderful but my side effects

are

> horriable. I am nausated and vomiting all the time and nothing

touches

> it. I have lost my appetitate, and many things that I enjoyed

taste

> different. COuld this be the gleevec and any suggestion on what I

can

> do?

>

> I saw my dr yesterday. My counts and all were fine. I have lost

more

> weight which has not mader her happy. I just simply cannot

maintain my

> weight. It will stay level for a few weeks and then its like

overnight

> I drop 6 or 7 pounds without trying. I know the nausea ets can't

be

> helping but I am at a lost as what to do.

>

> My Dr is concerned and mentioned yesterday about pulling me of

Gleevec

> and starting the new drug that has just been approved, Sprycel.

Anyone

> have any experience on that?

>

> Yesterday, I also received the results of my fish and pcr from my

last

> visit. Fish was normal but the PCr came back showing a 0.01%

increase.

> They told me it was nothing to worry about but they would be

watching

> me carefully. Is this something I should be worrying about. I had

> another fish and pcr done but won't have the results for about 2

> weeks. My concern is that there has been a three month window

between

> the fish i had in Jan and the one I had Yesterday.

>

> Any thoughts or direction you can give me.

>

> Thanks

>

[Guest guest]

Hi ,

From your description, I would say that you were intolerant of Gleevec.

There is no good reason for you to have such a bad quality of life on

Gleevec. It is definitely worth a shot to try Sprycel. There have been many

cases where the switch did away with the side effects and still maintained a

very low PCR result.

Your PCR increase is not significant. You didn't say what your PCR value

was. I don't understand why they continue to do FISH testing. Once you have

reached a low PCR level, there is no point in doing the FISH test.

Zavie

Zavie (age 68)

67 Shoreham Avenue

Ottawa, Canada, dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 309-296-0807

Cell: 613-202-0204

ID: zaviem

[ ] PCR When should i worry.

I have a question ( 2-Part)to throw out to the group. For the last few

years,all my test, fish and pcr have come back negative. I am so

gratefull for that and gleevec is wonderful but my side effects are

horriable. I am nausated and vomiting all the time and nothing touches

it. I have lost my appetitate, and many things that I enjoyed taste

different. COuld this be the gleevec and any suggestion on what I can

do?

I saw my dr yesterday. My counts and all were fine. I have lost more

weight which has not mader her happy. I just simply cannot maintain my

weight. It will stay level for a few weeks and then its like overnight

I drop 6 or 7 pounds without trying. I know the nausea ets can't be

helping but I am at a lost as what to do.

My Dr is concerned and mentioned yesterday about pulling me of Gleevec

and starting the new drug that has just been approved, Sprycel. Anyone

have any experience on that?

Yesterday, I also received the results of my fish and pcr from my last

visit. Fish was normal but the PCr came back showing a 0.01% increase.

They told me it was nothing to worry about but they would be watching

me carefully. Is this something I should be worrying about. I had

another fish and pcr done but won't have the results for about 2

weeks. My concern is that there has been a three month window between

the fish i had in Jan and the one I had Yesterday.

Any thoughts or direction you can give me.

Thanks