Re: Discolouration of Skin

[Guest guest]

Dear Bill,

I have a similar brown discoloration on my cheek -- like a small patch

of tanned skin that doesn't fade. It showed up last summer and has

remained. I have no idea if it's Gleevec-related, but I blame

everything on Gleevec, so why not? I've been on 400 mg. for two

years. I should probably go to a dermatologist, but I haven't done so.

Warm regards.

>

> Hi,

>

> I have had a weird discoloration (a medium brown colour) long and

thin

> line of pigmentation/discolouration come up on my nose of all

> places..has anybody else had some changes in skin pigmentation?

>

> I am on 400mg of Glivec for about a month now.

>

> Thanks

> Bil in the UK

>

[Guest guest]

Hi Bil,

A lot of us have skin issues while on Gleevec and that's because

Gleevec interferes with melanin production (that's what gives us our

skin colour)....the darker you are, the more melanin you have.

In most cases, people see their skin lighten. Some will see a general

lighting all over, others will see patches lighten. I wonder if the

streak of dark on your nose is really your original colour but the skin

around it has lightened making this streak stand out as dark?

For me, I only noticed my skin getting whiter around the 3rd year of

Gleevec and now it's so light that if it weren't for my grey coloured

eyes, I'm sure I'd get mistaken for an albino.

Take care,

Tracey

dx Jan 2002

>

> Hi,

>

> I have had a weird discoloration (a medium brown colour) long and

thin

> line of pigmentation/discolouration come up on my nose of all

> places..has anybody else had some changes in skin pigmentation?

>

> I am on 400mg of Glivec for about a month now.

>

> Thanks

> Bil in the UK

>

[Guest guest]

Hi Dave and Tracey,

yeah this is the same as s just on my nose..It must be the

Glivec..it is a " tanned spot " that is a weird shape even!

I am mixed race so it does not show up a lot but does definately show

up a bit..weird.

Traceys comment on the rest of the skin becoming lighter is

interesting because I look pale for my usual self so this could

possibly also be the case

I will see my Hemo tomorrow and I will ask her.

Thanks for the response.

Bil in the UK

> >

> > Hi,

> >

> > I have had a weird discoloration (a medium brown colour) long and

> thin

> > line of pigmentation/discolouration come up on my nose of all

> > places..has anybody else had some changes in skin pigmentation?

> >

> > I am on 400mg of Glivec for about a month now.

> >

> > Thanks

> > Bil in the UK

> >

>

[Guest guest]

I'm just super pale. To the point that if I walk by a white wall I almost

disapear (a joke my husband makes but not realy a joke, KWIM). Anyway, I don't

have any different color spots...except the dark circles under my eyes...but I

believe the pigment changes are directly related to the gleevec. Sorry.

:}

[ ] Discolouration of Skin

Hi,

I have had a weird discoloration (a medium brown colour) long and thin

line of pigmentation/ discolouration come up on my nose of all

places..has anybody else had some changes in skin pigmentation?

I am on 400mg of Glivec for about a month now.

Thanks

Bil in the UK

[Guest guest]

This is year two, and I'm noticing the same thing. Suddenly everyone is

suggesting that I " need some sun. "

>From: " Tracey " <traceyincanada@...>

>Reply-

>

>Subject: [ ] Re: Discolouration of Skin

>Date: Tue, 22 May 2007 12:22:13 -0000

>

>Hi Bil,

>

>A lot of us have skin issues while on Gleevec and that's because

>Gleevec interferes with melanin production (that's what gives us our

>skin colour)....the darker you are, the more melanin you have.

>

>In most cases, people see their skin lighten. Some will see a general

>lighting all over, others will see patches lighten. I wonder if the

>streak of dark on your nose is really your original colour but the skin

>around it has lightened making this streak stand out as dark?

>

>For me, I only noticed my skin getting whiter around the 3rd year of

>Gleevec and now it's so light that if it weren't for my grey coloured

>eyes, I'm sure I'd get mistaken for an albino.

>

>Take care,

>Tracey

>dx Jan 2002

>

>

>

> >

> > Hi,

> >

> > I have had a weird discoloration (a medium brown colour) long and

>thin

> > line of pigmentation/discolouration come up on my nose of all

> > places..has anybody else had some changes in skin pigmentation?

> >

> > I am on 400mg of Glivec for about a month now.

> >

> > Thanks

> > Bil in the UK

> >

>

>

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[Guest guest]

Hi All,

Don't post often but just to let you know that yes, my OH Ted also has a dark

splodge at the end of his nose ! Sometimes it shows more than others, but he's

had it for about four years since he started on Glivec. Have heard of others too

!

All the best from deepest, darkest Rutland, UK

Bee

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[Guest guest]

Hi!

I haven't really followed this thread but I do have a contribution to make.

I was on Gleevec for about 5 years and though already fair, I turned very

white. Now, I've been on Sprycel for almost a year and I'm still white as a

sheet. If I get any color poolside this summer I'll let you know.

L.

[ ] Re: Discolouration of Skin

>>Date: Tue, 22 May 2007 12:22:13 -0000

>>

>>Hi Bil,

>>

>>A lot of us have skin issues while on Gleevec and that's because

>>Gleevec interferes with melanin production (that's what gives us our

>>skin colour)....the darker you are, the more melanin you have.

>>

>>In most cases, people see their skin lighten. Some will see a general

>>lighting all over, others will see patches lighten. I wonder if the

>>streak of dark on your nose is really your original colour but the skin

>>around it has lightened making this streak stand out as dark?

>>

>>For me, I only noticed my skin getting whiter around the 3rd year of

>>Gleevec and now it's so light that if it weren't for my grey coloured

>>eyes, I'm sure I'd get mistaken for an albino.

>>

>>Take care,

>>Tracey

>>dx Jan 2002

>>

>>

>>

>> >

>> > Hi,

>> >

>> > I have had a weird discoloration (a medium brown colour) long and

>>thin

>> > line of pigmentation/discolouration come up on my nose of all

>> > places..has anybody else had some changes in skin pigmentation?

>> >

>> > I am on 400mg of Glivec for about a month now.

>> >

>> > Thanks

>> > Bil in the UK

>> >

>>

>>

>

> _________________________________________________________________

> PC Magazine's 2007 editors' choice for best Web mail-award-winning Windows

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>

>

>

>

>

[Guest guest]

Bil,

I visited with my dermatologist last week and he indicated that I have a case of

Melasma--a discoloration of the skin in the face that is normally associated

with pregnant women (so-called pregnancy mask). It can be triggered by

medicines and associated sun exposure--he thinks is might be related to Gleevec.

Nothing but cosmetic concerns, but he did suggest high-grade sunblock that

protects against both UVA and UVB rays applied daily.

> [ ] Discolouration of Skin

>

> Hi,

>

> I have had a weird discoloration (a medium brown colour) long and thin

> line of pigmentation/discolouration come up on my nose of all

> places..has anybody else had some changes in skin pigmentation?

>

> I am on 400mg of Glivec for about a month now.

>

> Thanks

> Bil in the UK

>

>

[Guest guest]

I gather from this that we should avoid exposure to the sun?

>From: mcwolvie@...

>Reply-

>

>Subject: Re: [ ] Discolouration of Skin

>Date: Tue, 22 May 2007 22:20:52 +0000

>

>Bil,

>

>I visited with my dermatologist last week and he indicated that I have a

>case of Melasma--a discoloration of the skin in the face that is normally

>associated with pregnant women (so-called pregnancy mask). It can be

>triggered by medicines and associated sun exposure--he thinks is might be

>related to Gleevec. Nothing but cosmetic concerns, but he did suggest

>high-grade sunblock that protects against both UVA and UVB rays applied

>daily.

>

>

> > [ ] Discolouration of Skin

> >

> > Hi,

> >

> > I have had a weird discoloration (a medium brown colour) long and thin

> > line of pigmentation/discolouration come up on my nose of all

> > places..has anybody else had some changes in skin pigmentation?

> >

> > I am on 400mg of Glivec for about a month now.

> >

> > Thanks

> > Bil in the UK

> >

> >

>

>

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[Guest guest]

>

> I gather from this that we should avoid exposure to the sun?

>

***************************************

Absolutely! This topic has been discussed at length but for newbies

who haven't been around to benefit from the discussions; anyone on

Gleevec should avoid sun exposure or use a strong sun screen when

outside.

Our skin doesn't have the ability to produce melanin like normal people

do because Gleevec inhibits this ability. Melanin is what gives your

skin pigment (colour) either on its own or through sun exposure (as in

a tan) so people on Gleevec burn very easily.

Tracey

[Guest guest]

Hi,

I do avoid the sun or at least lengthy exposure but I've heard others say

that sun exposure caused leathery red skin which did clear up.

L

[ ] Discolouration of Skin

>> >

>> > Hi,

>> >

>> > I have had a weird discoloration (a medium brown colour) long and thin

>> > line of pigmentation/discolouration come up on my nose of all

>> > places..has anybody else had some changes in skin pigmentation?

>> >

>> > I am on 400mg of Glivec for about a month now.

>> >

>> > Thanks

>> > Bil in the UK

>> >

>> >

>>

>>

>

> _________________________________________________________________

> Like the way Microsoft Office Outlook works? You'll love Windows Live

> Hotmail.

>

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>

>

>

>

>

[Guest guest]

Wow, I'm so glad you told me this, Tracey. As I looked with shock at my

pallid reflection in the mirror this morning, I thought " maybe I should get

some sun. " Au contraire! Thanks so much.

>From: " Tracey " <traceyincanada@...>

>Reply-

>

>Subject: Re: [ ] Discolouration of Skin

>Date: Tue, 22 May 2007 22:56:09 -0000

>

>

> >

> > I gather from this that we should avoid exposure to the sun?

> >

>***************************************

>

>

>Absolutely! This topic has been discussed at length but for newbies

>who haven't been around to benefit from the discussions; anyone on

>Gleevec should avoid sun exposure or use a strong sun screen when

>outside.

>

>Our skin doesn't have the ability to produce melanin like normal people

>do because Gleevec inhibits this ability. Melanin is what gives your

>skin pigment (colour) either on its own or through sun exposure (as in

>a tan) so people on Gleevec burn very easily.

>

>Tracey

>

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[Guest guest]

This has been very helpful to me, and I'm grateful for all the information.

>From: chris mahathey <mdcfam3@...>

>Reply-

>

>Subject: Re: [ ] Discolouration of Skin

>Date: Tue, 22 May 2007 17:40:00 -0700 (PDT)

>

>No offense but enough with the skin already

>

>

> [ ] Discolouration of Skin

> >> >

> >> > Hi,

> >> >

> >> > I have had a weird discoloration (a medium brown colour) long and

>thin

> >> > line of pigmentation/ discolouration come up on my nose of all

> >> > places..has anybody else had some changes in skin pigmentation?

> >> >

> >> > I am on 400mg of Glivec for about a month now.

> >> >

> >> > Thanks

> >> > Bil in the UK

> >> >

> >> >

> >>

> >>

> >

> > ____________ _________ _________ _________ _________ _________ _

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>TAGHM_migration_ HM_mini_outlook_ 0507

> >

> >

> >

> >

> >

[Guest guest]

Hi ,

I know how disconcerting the Gleevec pallor can be. You could always

try one of those self tanners that you put on like lotion although I

have to say that the one I tried, came out all streaky. I looked

like I hadn't washed in a month so I decided that the albino look was

more appealing than than filthy look but you may be luckier than I

was. Let me know if you find a lotion that works well

Tracey

--- In , " Rosen Lum " <rrosenlum@...>

wrote:

>

> Wow, I'm so glad you told me this, Tracey. As I looked with shock

at my

> pallid reflection in the mirror this morning, I thought " maybe I

should get

> some sun. " Au contraire! Thanks so much.

>

>