Guest guest Posted April 24, 2007 Report Share Posted April 24, 2007 I just received my PCR from MDACC after weeks of requesting it. It seems that there was some sort of mix up and they never ran my labs. My PCR jumped from .5 in March of 2006 to 6.67 in March of 2007. The only thing that has changed is that I have gone from 600 mg to 400 mg and I take several breaks a year due to intolerable side effects. Anyone experienced an increase due to lowering of dosage and if so, did your PCR return once you returned to a higher dose? Sincerely, Matt ville, Florida Dx January of 2005 Gleevec since March of 2005 Treated at MD Father of 3 ************************************** See what's free at http://www.aol.com. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 25, 2007 Report Share Posted April 25, 2007 Hi Matt, Was your latest PCR from serum or marrow? Either way I recommend you get it tested again right away. If the last one was from blood, I'd ask for a BMA this time, with marrow exam and cytogenetics as well as PCR to look for morphological and chromosomal changes. If the change is real, I'd also request mutation testing and a second opinion on changing to one of the newer drugs. I don't mean to alarm you, but if your latest PCR is real, you have experienced a 2 log increase in your CML load, which quite a lot more than what one would expect from a dosage reduction alone. And in the unlikely event that you are accelerating rather then just developing some minor resistance to Gleevec, then time is of the essence. Good luck, R > > I just received my PCR from MDACC after weeks of requesting it. It seems > that there was some sort of mix up and they never ran my labs. My PCR jumped > from .5 in March of 2006 to 6.67 in March of 2007. The only thing that has > changed is that I have gone from 600 mg to 400 mg and I take several breaks a > year due to intolerable side effects. > > Anyone experienced an increase due to lowering of dosage and if so, did your > PCR return once you returned to a higher dose? > > Sincerely, > > Matt > ville, Florida > Dx January of 2005 > Gleevec since March of 2005 > Treated at MD > Father of 3 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 30, 2008 Report Share Posted January 30, 2008 What is the difference between a RT-PCR and a QT-PCR, can anyone tell me? Matt ville, FL Gleevec Starting in January 2005 Tasigna Since November 2007 **************Start the year off right. Easy ways to stay in shape. http://body.aol.com/fitness/winter-exercise?NCID=aolcmp00300000002489 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 31, 2008 Report Share Posted January 31, 2008 The PCR test that most of us get is spelled Quantitative Real Time Polymerase Chain Reaction, noted qRT-PCR, QRT-PCR or sometime RT-qPCR. From what I can see over the net QT-PCR is the same thing, just another name, but I may be wrong, it is quite a jungle. RT-PCR can be quantitative (the most common) or qualitative. The first give the quantity of some molecule, the second just tells if it is present. Here's the wikipedia page on RT-PCR http://en.wikipedia.org/wiki/Real-time_polymerase_chain_reaction Marcos, On Jan 30, 2008 7:08 PM, <mtmaynor@...> wrote: > > > > > What is the difference between a RT-PCR and a QT-PCR, > can anyone tell me? > > Matt > ville, FL > Gleevec Starting in January 2005 > Tasigna Since November 2007 > > **************Start the year off right. Easy ways to stay in shape. > http://body.aol.com/fitness/winter-exercise?NCID=aolcmp00300000002489 > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 31, 2008 Report Share Posted January 31, 2008 Oh, I forgot, RT means also Reverse Transcription. Reverse Transcription PCR is the lab technique used to get the Real Time PCR, well it is so simple I work with a colleague that is a molecular biologist and she tried to explain the details once but I quickly got lost in the jargon. Marcos. On Jan 30, 2008 8:17 PM, Marcos Perreau Guimaraes <montereyunderwater@...> wrote: > The PCR test that most of us get is spelled Quantitative Real Time > Polymerase Chain Reaction, noted qRT-PCR, QRT-PCR or sometime RT-qPCR. > From what I can see over the net QT-PCR is the same thing, just > another name, but I may be wrong, it is quite a jungle. RT-PCR can be > quantitative (the most common) or qualitative. The first give the > quantity of some molecule, the second just tells if it is present. > Here's the wikipedia page on RT-PCR > http://en.wikipedia.org/wiki/Real-time_polymerase_chain_reaction > Marcos, > > On Jan 30, 2008 7:08 PM, <mtmaynor@...> wrote: > > > > > > > > > > What is the difference between a RT-PCR and a QT-PCR, > > can anyone tell me? > > > > Matt > > ville, FL > > Gleevec Starting in January 2005 > > Tasigna Since November 2007 > > > > **************Start the year off right. Easy ways to stay in shape. > > http://body.aol.com/fitness/winter-exercise?NCID=aolcmp00300000002489 > > > > Quote Link to comment Share on other sites More sharing options...
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