Guest guest Posted April 25, 2007 Report Share Posted April 25, 2007 [i'm posting this again because my last email apparently didn't go through. Another note I sent in response to came through with her original note, but not my reply! I agree with Tracey, there's something odd going on here!] Hi Matt, Was your latest PCR from serum or marrow? Either way I recommend you get it tested again right away. If the last one was from blood, I'd ask for a BMA this time, with marrow exam and cytogenetics as well as PCR to look for morphological and chromosomal changes. If the change is real, you should also request mutation testing and a second opinion on changing to one of the newer drugs. I don't mean to alarm you, but if your latest PCR is real you have experienced a 2 log increase in your CML load, which quite a lot more than what one would expect from a dosage reduction alone. And in the unlikely event that you are accelerating rather then just developing some minor resistance to Gleevec, then time is of the essence. Good luck, R > > I just received my PCR from MDACC after weeks of requesting it. It seems > that there was some sort of mix up and they never ran my labs. My PCR jumped > from .5 in March of 2006 to 6.67 in March of 2007. The only thing that has > changed is that I have gone from 600 mg to 400 mg and I take several breaks a > year due to intolerable side effects. > > Anyone experienced an increase due to lowering of dosage and if so, did your > PCR return once you returned to a higher dose? > > Sincerely, > > Matt > ville, Florida > Dx January of 2005 > Gleevec since March of 2005 Quote Link to comment Share on other sites More sharing options...
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