Guest guest Posted June 21, 2007 Report Share Posted June 21, 2007 Hi Everyone, Chris's recent experience has caused me to go back and check a few drugs to see how they metabolize and I have found some interesting things. For anyone who wants to read the technical information regarding Gleevec, you can find a good synopsis here: http://www.drugs.com/pro/gleevec.html Where it lists the drugs that may have their plasma levels altered by Gleevec you'll see that Acetaminophen (Tylenol) is specifically listed. We've known for years that we weren't supposed to take Tylenol because it can " compete with Gleevec for metabolization " but this was the first time I read that when taken together, the plasma level for Tylenol can actually increase. So in other words, a 500mg pill of Tylenol, could potentially be double or triple that in your system. Having higher levels of Acetaminophen in your blood will obviously make the risk of toxicity greater which is something we want to avoid if at all possible. Another interesting site I found: http://www.medscape.com/viewarticle/444804_5 Describes the CYP3A4 isoenzyme (the one that Gleevec uses for metabolization). It says that about 50% of drugs use this isoenzyme including exogenous corticosteroids. I often use Hydrocortisone for eczema but I never thought that it could interact with Gleevec. I'm not sure how much cream would need to be used in order to cause a significant interaction, but it's something to think about I guess. Also of note, I found that plasma levels of Diphenhydramine Hydrochloride (AKA Benadryl), can be increased when taken with Gleevec because the Benadryl uses the P450 2D6 isoenzyme to metabolize which Gleevec can inhibit. http://www.nhtsa.dot.gov/PEOPLE/injury/research/job185drugs/diphenhydr amine.htm The theraputic range for Benadryl is fairly wide so I'm not sure how significant this finding is but it's made me realize that when it comes to taking a dose of Benadryl, size can matter and smaller is better I guess the moral of my story is that it's very important to check out each drug we take to know exactly how or if it will interact with Gleevec. Tracey Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 25, 2007 Report Share Posted June 25, 2007 I'm not sure what your question is or which count you're referring to. Which of your counts is 40%? Is this your blast count? If you have 40% blasts, I would say that this is very high, not low at all. Tracey > > > I am in the blast stage and pain and ankle joint is > always pain for me. > > As for today my count is 40.0% which means it is too > low.I am still on spycell and i do not know what is > reducing the count so low. > > Any help please form anyone > > > > ______________________________________________________________________ ______________ > oneSearch: Finally, mobile search > that gives answers, not web links. > http://mobile./mobileweb/onesearch?refer=1ONXIC > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 25, 2007 Report Share Posted June 25, 2007 Thank you very much for your knowledge. The ankle pain is just bothersome when I lay down... like restless leg syndrome. I feel really healthy other than the usual muscle aches. Sprycell is working well for me. Tracey <traceyincanada@...> wrote: Hi , Pain of any kind could be for any reason. It doesn't necessarily mean that Sprycel is at the root of it, or even CML for that matter. My ankle recently started hurting me as well, but I figured out that it was because of the way I was sitting on it in the garden and not anything ominous. After I stopped sitting on it like that, the pain went away. Don't worry about your ALT , 45 is barely even elevated. If there was anything going on with your liver, it would not only be much much higher but your ALP, bilirubin and AST would also be sky high. Take care, Tracey > I am in the blast stage and pain and ankle joint is > always pain for me. > > As for today my count is 40.0% which means it is too > low.I am still on spycell and i do not know what is > reducing the count so low. > > Any help please form anyone > > __________________________________________________________ > oneSearch: Finally, mobile search > that gives answers, not web links. > http://mobile./mobileweb/onesearch?refer=1ONXIC > > > > > > --------------------------------- > Ready for the edge of your seat? Check out tonight's top picks on TV. > > Quote Link to comment Share on other sites More sharing options...
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