Guest guest Posted June 19, 2007 Report Share Posted June 19, 2007 I don't post often, but read all the posts. Here is my predicament. I was diagnosed in May 2005 and started on 400mg of gleevec. My first oncologist yo-yo'ed with my dose between 400mg all the down to 100mg. Not knowing at the time what I know now, I realize he shouldn't have done this and I switched dr.'s after about 5 months with him. It took me almost 2 years to reach FISH negative (0%). I reached MCR (major cytogenic response) after 6 months, but just could not reach that zero. My dr. increased my dose in 2/07 to 600mg hoping to push me into CCR. My FISH results in Feb. 2007 were zero and pcr was 0.020. FISH (June '07) just came back at 2.5% and pcr was up to .125%. Plus, since the increase, I have had excessive swelling/fluid retention in my legs, ankles, abdomen. Talked to the dr. yesterday and he wants to switch me to sprycel because of the swelling and increase in pcr/fish. I am just wondering if this is the right thing to do? I was hoping to get more than 2 years out of gleevec. Any thoughts on this? DX 5/05 600mg gleevec Quote Link to comment Share on other sites More sharing options...
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