Guest guest Posted June 18, 2007 Report Share Posted June 18, 2007 Well, my husband went off Gleevec for 4 weeks waiting for his liver to " recover " (it was at 6x the normal toxicity rate). It did recover to the " normal " range and he resumed Gleevec last week at a 300mg doseage (100 less than his normal). He has been on 300mg of Gleevec for 7 days, and his liver shot back up to 4x the toxicity rate...in just 7 days. It appears that he will have to go off Gleevec due to these liver issues and onto Sprycel, although we are awaiting a call from his doctor to discuss all of this...but we sort of already discussed that if his liver did not " tolerate " Gleeevec, we would start looking at Sprycel. We have an appt July 26th with Dr. Druker, and until then, will just follow the directions of 's oncologist....He was only on Gleevec about 9 months all together and he felt quite well, so we are disappointed that he is in the less than 5% of people who have to go OFF of it due to these liver issues. At this point it does seem like this is a huge indication that his liver cannot tolerate Gleevec--after having been off of it, his liver returning to normal, then once Gleevec started again, his liver jumps back to high toxicity levels....right? Has anyone else on this forum had these same type of issues? Regards, Cervera wife of Cervera, age 34 diagnosed 06/2006, 400mg/Gleevec _________________________________________________________________ Get a preview of Live Earth, the hottest event this summer - only on MSN http://liveearth.msn.com?source=msntaglineliveearthhm Quote Link to comment Share on other sites More sharing options...
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