Re: Traveling with Gleevec

June 26, 2007

This brings up a great question and point: my Gleevec is sent to me monthy,

via FedEx. It is not climate controlled for the time it is away from my mail

away drug co. I know it seems to be working for me, so for me a few days

without climate control, my Gleevec does seem to be working. But, still

worries me with some of the roller coaster WBC's I have had.

Chris

************************************** See what's free at http://www.aol.com.

June 26, 2007

First, is these temperatures tolerances so drastic ? Is this not for long

term storage ? I never took care of it, maybe I should. Even if temperatures

in the San Francisco area aren't too extreme, it gets sometime above 100 in

my apartment (I hate AC).

For the second part, how remote is the place you are going in France (I am

French) ? France is a rather small country (yeah, I said it ), and it is

not so easy to get very far from civilization, unless you are camping in the

middle of Corsica. Large airports and the TGV trains have AC (I don't know

for the smaller trains, probably depends on how small the line).

Marcos.

On 6/26/07, lightday63 <lightday63@...> wrote:

>

> I'm planning a trip to a remote area of France where the temperatures

> are often in the high 90's. The temperature tolerance of Gleevec is

> between 59 and 86. I would be traveling on hot non air conditioned

> trains, in hot train stations, and sometimes hot airports. I was

> thinking of ways to keep the Gleevec safe, but haven't come up with

> anything very pracitical. The best I can come up with is carrying the

> Gleevec in an insulated lunch bag with some ice and a thermometer. I

> would need to check the temp often to make sure it wasn't too hot or

> too cold. This plan has risks of being caught in an unexpected

> situation with no access to ice. My Dr. says that being without daily

> Gleevec at this time could be extremely dangerous for me. I am

> thinking of canceling the trip. Any suggestions would be appreciated.

>

> Thanks,

>

--

Marcos Perreau Guimaraes

Suppes Brain Lab

Ventura Hall - CSLI

Stanford University

220 Panama street

Stanford CA 94305-4101

650 329 9920 x 305

650 630 5015 (cell)

marcospg@...

montereyunderwater@...

www.stanford.edu/~marcospg/

June 26, 2007

Hi ,

Your doctor appears to be an alarmist. I have never heard that

missing a dose or two of Gleevec could be extremely dangerous.

Just because the tolerance level is 59-86 doesn't mean that Gleevec

stops being ineffective at 90. Maybe if the 90 degee temperature was

maintaind for several weeks or months there might be a

deterioration.

Most likely these temperatures would occur for a couple of hours

during the day and wouldn't be long enough to alter the

affectiveness.

I would suggest that you speak with your pharmacist and ask him. You

could call Novartis directly and ask speak to someone who could

advise you.

Zavie

>

> I'm planning a trip to a remote area of France where the

temperatures

> are often in the high 90's. The temperature tolerance of Gleevec

is

> between 59 and 86. I would be traveling on hot non air

conditioned

> trains, in hot train stations, and sometimes hot airports. I was

> thinking of ways to keep the Gleevec safe, but haven't come up

with

> anything very pracitical. The best I can come up with is carrying

the

> Gleevec in an insulated lunch bag with some ice and a

thermometer. I

> would need to check the temp often to make sure it wasn't too hot

or

> too cold. This plan has risks of being caught in an unexpected

> situation with no access to ice. My Dr. says that being without

daily

> Gleevec at this time could be extremely dangerous for me. I am

> thinking of canceling the trip. Any suggestions would be

appreciated.

>

> Thanks,

>

June 26, 2007

Hi Marcos -

Thanks for getting back to me. I talked to the Novartis Company that

makes Gleevec. They said once the drug goes outside these two

temperature limits (59 and 86) it's effectivess is compromised or

even destroyed.

I've made this trip many times in the past. It's a coastal resort

about 10 miles from Soulac Sur Mer. The trains to this city are not

air conditioned. One time on the way to Soulac, the train was

stalled for about 45 minutes and it really got hot. There is no

dining car with ice, etc.

> >

> > I'm planning a trip to a remote area of France where the

temperatures

> > are often in the high 90's. The temperature tolerance of Gleevec

is

> > between 59 and 86. I would be traveling on hot non air conditioned

> > trains, in hot train stations, and sometimes hot airports. I was

> > thinking of ways to keep the Gleevec safe, but haven't come up

with

> > anything very pracitical. The best I can come up with is carrying

the

> > Gleevec in an insulated lunch bag with some ice and a

thermometer. I

> > would need to check the temp often to make sure it wasn't too hot

or

> > too cold. This plan has risks of being caught in an unexpected

> > situation with no access to ice. My Dr. says that being without

daily

> > Gleevec at this time could be extremely dangerous for me. I am

> > thinking of canceling the trip. Any suggestions would be

appreciated.

> >

> > Thanks,

> >

>

> --

> Marcos Perreau Guimaraes

> Suppes Brain Lab

> Ventura Hall - CSLI

> Stanford University

> 220 Panama street

> Stanford CA 94305-4101

> 650 329 9920 x 305

> 650 630 5015 (cell)

> marcospg@...

> montereyunderwater@...

> www.stanford.edu/~marcospg/

>

June 26, 2007

If you have the money for this trip , and you have the time , don't wait to

enjoy your life .

You don't know what can happen next year .

I can take your place and bring you back photos !!!!

Have a nice hollayday .

Emile

Dx Dec 2003

# 527 Zavie's Club

I'm planning a trip to a remote area of France where the temperatures

are often in the high 90's. The temperature tolerance of Gleevec is

between 59 and 86. I would be traveling on hot non air conditioned

trains, in hot train stations, and sometimes hot airports. I was

thinking of ways to keep the Gleevec safe, but haven't come up with

anything very pracitical. The best I can come up with is carrying the

Gleevec in an insulated lunch bag with some ice and a thermometer. I

would need to check the temp often to make sure it wasn't too hot or

too cold. This plan has risks of being caught in an unexpected

situation with no access to ice. My Dr. says that being without daily

Gleevec at this time could be extremely dangerous for me. I am

thinking of canceling the trip. Any suggestions would be appreciated.

Thanks,

------------------------------------------------------------------------------

June 26, 2007

We just came back from a trip to Key West and my

mother takes Gleevec and we have not heard that

it has to be kept at a certain temp. In fact this

is the first time I have ever heard it. Maybe

they should make people aware of these things

because we traveled by train and did nothing to

protect her meds. Thanks for the info.

--- lightday63 <lightday63@...> wrote:

> I'm planning a trip to a remote area of France

> where the temperatures

> are often in the high 90's. The temperature

> tolerance of Gleevec is

> between 59 and 86. I would be traveling on hot

> non air conditioned

> trains, in hot train stations, and sometimes

> hot airports. I was

> thinking of ways to keep the Gleevec safe, but

> haven't come up with

> anything very pracitical. The best I can come

> up with is carrying the

> Gleevec in an insulated lunch bag with some ice

> and a thermometer. I

> would need to check the temp often to make sure

> it wasn't too hot or

> too cold. This plan has risks of being caught

> in an unexpected

> situation with no access to ice. My Dr. says

> that being without daily

> Gleevec at this time could be extremely

> dangerous for me. I am

> thinking of canceling the trip. Any

> suggestions would be appreciated.

>

> Thanks,

>

~Stacey Thacker~

________________________________________________________________________________\

____

Park yourself in front of a world of choices in alternative vehicles. Visit the

Auto Green Center.

http://autos./green_center/

June 26, 2007

The notice does say to store it between 15C and 30C, which correspond in

Fahrenheit to the 59F and 86F mentioned. What I am wondering is what it

means in terms of time. Having the pills at 100F for 1h is it ok ? For 1

day, 1 week or 1 month ? If gleevec is destroyed in a few hours at 100F I

would hope the notice, the pharmacy and the dr would be a little more

concerned about the problem. I am seeing my dr in 10 days, I ll ask him,

although I doubt he ll have a definitive answer.

Marcos.

On 6/26/07, Stacey Thacker <Stacey1599@...> wrote:

>

> We just came back from a trip to Key West and my

> mother takes Gleevec and we have not heard that

> it has to be kept at a certain temp. In fact this

> is the first time I have ever heard it. Maybe

> they should make people aware of these things

> because we traveled by train and did nothing to

> protect her meds. Thanks for the info.

>

> --- lightday63 <lightday63@... <lightday63%40>> wrote:

>

> > I'm planning a trip to a remote area of France

> > where the temperatures

> > are often in the high 90's. The temperature

> > tolerance of Gleevec is

> > between 59 and 86. I would be traveling on hot

> > non air conditioned

> > trains, in hot train stations, and sometimes

> > hot airports. I was

> > thinking of ways to keep the Gleevec safe, but

> > haven't come up with

> > anything very pracitical. The best I can come

> > up with is carrying the

> > Gleevec in an insulated lunch bag with some ice

> > and a thermometer. I

> > would need to check the temp often to make sure

> > it wasn't too hot or

> > too cold. This plan has risks of being caught

> > in an unexpected

> > situation with no access to ice. My Dr. says

> > that being without daily

> > Gleevec at this time could be extremely

> > dangerous for me. I am

> > thinking of canceling the trip. Any

> > suggestions would be appreciated.

> >

> > Thanks,

> >

>

> ~Stacey Thacker~

>

> __________________________________________________________

> Park yourself in front of a world of choices in alternative vehicles.

> Visit the Auto Green Center.

> http://autos./green_center/

>

--

Marcos Perreau Guimaraes

Suppes Brain Lab

Ventura Hall - CSLI

Stanford University

220 Panama street

Stanford CA 94305-4101

650 329 9920 x 305

650 630 5015 (cell)

marcospg@...

montereyunderwater@...

www.stanford.edu/~marcospg/

June 26, 2007

That's a good point Marcos. On top of that, wouldn't you say that

many of our houses can get warmer than 86 degrees in the summer? I'm

sure not everyone has air conditioning. And what about the people

who deliver the drugs to the pharmacies, do they have the drug

temperature controlled? I doubt it.

Tracey

> >

> > > I'm planning a trip to a remote area of France

> > > where the temperatures

> > > are often in the high 90's. The temperature

> > > tolerance of Gleevec is

> > > between 59 and 86. I would be traveling on hot

> > > non air conditioned

> > > trains, in hot train stations, and sometimes

> > > hot airports. I was

> > > thinking of ways to keep the Gleevec safe, but

> > > haven't come up with

> > > anything very pracitical. The best I can come

> > > up with is carrying the

> > > Gleevec in an insulated lunch bag with some ice

> > > and a thermometer. I

> > > would need to check the temp often to make sure

> > > it wasn't too hot or

> > > too cold. This plan has risks of being caught

> > > in an unexpected

> > > situation with no access to ice. My Dr. says

> > > that being without daily

> > > Gleevec at this time could be extremely

> > > dangerous for me. I am

> > > thinking of canceling the trip. Any

> > > suggestions would be appreciated.

> > >

> > > Thanks,

> > >

> >

> > ~Stacey Thacker~

> >

> > __________________________________________________________

> > Park yourself in front of a world of choices in alternative

vehicles.

> > Visit the Auto Green Center.

> > http://autos./green_center/

> >

>

> --

> Marcos Perreau Guimaraes

> Suppes Brain Lab

> Ventura Hall - CSLI

> Stanford University

> 220 Panama street

> Stanford CA 94305-4101

> 650 329 9920 x 305

> 650 630 5015 (cell)

> marcospg@...

> montereyunderwater@...

> www.stanford.edu/~marcospg/

>

June 26, 2007

Hi Zavie,

Thanks for your answer. I did talk directly to a representative at

Novartis and I also sent them an e-mail. They said that once the

drug was outside this temperature range they could no longer

guarentee its effectiveness or safety. They would not or could not

say how quickly the deterioration happens.

> >

> > I'm planning a trip to a remote area of France where the

> temperatures

> > are often in the high 90's. The temperature tolerance of Gleevec

> is

> > between 59 and 86. I would be traveling on hot non air

> conditioned

> > trains, in hot train stations, and sometimes hot airports. I was

> > thinking of ways to keep the Gleevec safe, but haven't come up

> with

> > anything very pracitical. The best I can come up with is

carrying

> the

> > Gleevec in an insulated lunch bag with some ice and a

> thermometer. I

> > would need to check the temp often to make sure it wasn't too hot

> or

> > too cold. This plan has risks of being caught in an unexpected

> > situation with no access to ice. My Dr. says that being without

> daily

> > Gleevec at this time could be extremely dangerous for me. I am

> > thinking of canceling the trip. Any suggestions would be

> appreciated.

> >

> > Thanks,

> >

>

June 26, 2007

My Gleevec by Medco is delivered by UPS when temp is 80 it is sent in a cold

package,other times just in an envelope. Don,t have info on long range,but do

put my supply in the fridge

[ ] Re: Traveling with Gleevec

Hi Zavie,

Thanks for your answer. I did talk directly to a representative at

Novartis and I also sent them an e-mail. They said that once the

drug was outside this temperature range they could no longer

guarentee its effectiveness or safety. They would not or could not

say how quickly the deterioration happens.

> >

> > I'm planning a trip to a remote area of France where the

> temperatures

> > are often in the high 90's. The temperature tolerance of Gleevec

> is

> > between 59 and 86. I would be traveling on hot non air

> conditioned

> > trains, in hot train stations, and sometimes hot airports. I was

> > thinking of ways to keep the Gleevec safe, but haven't come up

> with

> > anything very pracitical. The best I can come up with is

carrying

> the

> > Gleevec in an insulated lunch bag with some ice and a

> thermometer. I

> > would need to check the temp often to make sure it wasn't too hot

> or

> > too cold. This plan has risks of being caught in an unexpected

> > situation with no access to ice. My Dr. says that being without

> daily

> > Gleevec at this time could be extremely dangerous for me. I am

> > thinking of canceling the trip. Any suggestions would be

> appreciated.

> >

> > Thanks,

> >

>

________________________________________________________________________________\

____

Park yourself in front of a world of choices in alternative vehicles. Visit the

Auto Green Center.

http://autos./green_center/

June 27, 2007

Mine is delivered via mail order and during the summer, it's in a Styrofoam

box with an ice pack.

Barbara Hundley

_____

From: [mailto: ] On Behalf Of Tracey

Sent: Tuesday, June 26, 2007 9:41 PM

Subject: Re: [ ] Traveling with Gleevec

That's a good point Marcos. On top of that, wouldn't you say that

many of our houses can get warmer than 86 degrees in the summer? I'm

sure not everyone has air conditioning. And what about the people

who deliver the drugs to the pharmacies, do they have the drug

temperature controlled? I doubt it.

Tracey

> >

> > > I'm planning a trip to a remote area of France

> > > where the temperatures

> > > are often in the high 90's. The temperature

> > > tolerance of Gleevec is

> > > between 59 and 86. I would be traveling on hot

> > > non air conditioned

> > > trains, in hot train stations, and sometimes

> > > hot airports. I was

> > > thinking of ways to keep the Gleevec safe, but

> > > haven't come up with

> > > anything very pracitical. The best I can come

> > > up with is carrying the

> > > Gleevec in an insulated lunch bag with some ice

> > > and a thermometer. I

> > > would need to check the temp often to make sure

> > > it wasn't too hot or

> > > too cold. This plan has risks of being caught

> > > in an unexpected

> > > situation with no access to ice. My Dr. says

> > > that being without daily

> > > Gleevec at this time could be extremely

> > > dangerous for me. I am

> > > thinking of canceling the trip. Any

> > > suggestions would be appreciated.

> > >

> > > Thanks,

> > >

> >

> > ~Stacey Thacker~

> >

> > __________________________________________________________

> > Park yourself in front of a world of choices in alternative

vehicles.

> > Visit the Auto Green Center.

> > http://autos. <http://autos./green_center/>

/green_center/

> >

>

> --

> Marcos Perreau Guimaraes

> Suppes Brain Lab

> Ventura Hall - CSLI

> Stanford University

> 220 Panama street

> Stanford CA 94305-4101

> 650 329 9920 x 305

> 650 630 5015 (cell)

> marcospg@...

> montereyunderwater@...

> www.stanford.edu/~marcospg/

>

June 27, 2007

,

The fridge may not be the best place for your Gleevec because the

temperature would be below 59.

> > >

> > > I'm planning a trip to a remote area of France where the

> > temperatures

> > > are often in the high 90's. The temperature tolerance of

Gleevec

> > is

> > > between 59 and 86. I would be traveling on hot non air

> > conditioned

> > > trains, in hot train stations, and sometimes hot airports. I

was

> > > thinking of ways to keep the Gleevec safe, but haven't come up

> > with

> > > anything very pracitical. The best I can come up with is

> carrying

> > the

> > > Gleevec in an insulated lunch bag with some ice and a

> > thermometer. I

> > > would need to check the temp often to make sure it wasn't too

hot

> > or

> > > too cold. This plan has risks of being caught in an unexpected

> > > situation with no access to ice. My Dr. says that being without

> > daily

> > > Gleevec at this time could be extremely dangerous for me. I am

> > > thinking of canceling the trip. Any suggestions would be

> > appreciated.

> > >

> > > Thanks,

> > >

> >

>

______________________________________________________________________

______________

> Park yourself in front of a world of choices in alternative

vehicles. Visit the Auto Green Center.

> http://autos./green_center/

>

June 27, 2007

Isn't fridge temperature lower than 59 degree?

> > >

> > > I'm planning a trip to a remote area of France where the

> > temperatures

> > > are often in the high 90's. The temperature tolerance of

Gleevec

> > is

> > > between 59 and 86. I would be traveling on hot non air

> > conditioned

> > > trains, in hot train stations, and sometimes hot airports. I

was

> > > thinking of ways to keep the Gleevec safe, but haven't come up

> > with

> > > anything very pracitical. The best I can come up with is

> carrying

> > the

> > > Gleevec in an insulated lunch bag with some ice and a

> > thermometer. I

> > > would need to check the temp often to make sure it wasn't too

hot

> > or

> > > too cold. This plan has risks of being caught in an unexpected

> > > situation with no access to ice. My Dr. says that being without

> > daily

> > > Gleevec at this time could be extremely dangerous for me. I am

> > > thinking of canceling the trip. Any suggestions would be

> > appreciated.

> > >

> > > Thanks,

> > >

> >

>

______________________________________________________________________

______________

> Park yourself in front of a world of choices in alternative

vehicles. Visit the Auto Green Center.

> http://autos./green_center/

>

June 27, 2007

Sounds as consistent as PCR testing

I found a 2004 document from the European Medicines Agency that says, I quote :

" Stability

Preliminary investigations have established the main degradation

pathways , e.g. oxidation to N-oxide under oxidative stress

conditions. Degradation was not observed after storage at high

temperatures (100ºC). "

100C is 212F, if you place gets that warm call the firefighters

Reference :

http://www.emea.europa.eu/humandocs/PDFs/EPAR/glivec/241801en6.pdf

(glivec is the name used in Europe, don't ask why, but it is the same

drug and the same packaging).

Marcos.

On 6/26/07, barbara <barb521@...> wrote:

>

> Mine is delivered via mail order and during the summer, it's in a Styrofoam

> box with an ice pack.

>

> Barbara Hundley

>

> _____

>

> From: [mailto: ] On Behalf Of Tracey

> Sent: Tuesday, June 26, 2007 9:41 PM

>

> Subject: Re: [ ] Traveling with Gleevec

>

> That's a good point Marcos. On top of that, wouldn't you say that

> many of our houses can get warmer than 86 degrees in the summer? I'm

> sure not everyone has air conditioning. And what about the people

> who deliver the drugs to the pharmacies, do they have the drug

> temperature controlled? I doubt it.

>

> Tracey

>

> > >

> > > > I'm planning a trip to a remote area of France

> > > > where the temperatures

> > > > are often in the high 90's. The temperature

> > > > tolerance of Gleevec is

> > > > between 59 and 86. I would be traveling on hot

> > > > non air conditioned

> > > > trains, in hot train stations, and sometimes

> > > > hot airports. I was

> > > > thinking of ways to keep the Gleevec safe, but

> > > > haven't come up with

> > > > anything very pracitical. The best I can come

> > > > up with is carrying the

> > > > Gleevec in an insulated lunch bag with some ice

> > > > and a thermometer. I

> > > > would need to check the temp often to make sure

> > > > it wasn't too hot or

> > > > too cold. This plan has risks of being caught

> > > > in an unexpected

> > > > situation with no access to ice. My Dr. says

> > > > that being without daily

> > > > Gleevec at this time could be extremely

> > > > dangerous for me. I am

> > > > thinking of canceling the trip. Any

> > > > suggestions would be appreciated.

> > > >

> > > > Thanks,

> > > >

> > >

> > > ~Stacey Thacker~

> > >

> > > __________________________________________________________

> > > Park yourself in front of a world of choices in alternative

> vehicles.

> > > Visit the Auto Green Center.

> > > http://autos. <http://autos./green_center/>

>

> /green_center/

> > >

> >

> > --

> > Marcos Perreau Guimaraes

> > Suppes Brain Lab

> > Ventura Hall - CSLI

> > Stanford University

> > 220 Panama street

> > Stanford CA 94305-4101

> > 650 329 9920 x 305

> > 650 630 5015 (cell)

> > marcospg@...

> > montereyunderwater@...

> > www.stanford.edu/~marcospg/

> >

June 27, 2007

Hi Marcos,

Thank you for digging out that refererence.

There are very few medications that are very sensitive to temperature.

Zavie

Zavie (age 69)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 309-296-0807

Cell: 613-202-0204

ID: zaviem

_____

From: [mailto: ] On Behalf Of Marcos

Perreau Guimaraes

Sent: June 26, 2007 10:56 PM

Subject: Re: [ ] Traveling with Gleevec

Sounds as consistent as PCR testing

I found a 2004 document from the European Medicines Agency that says, I

quote :

" Stability

Preliminary investigations have established the main degradation

pathways , e.g. oxidation to N-oxide under oxidative stress

conditions. Degradation was not observed after storage at high

temperatures (100ºC). "

100C is 212F, if you place gets that warm call the firefighters

Reference :

http://www.emea.

<http://www.emea.europa.eu/humandocs/PDFs/EPAR/glivec/241801en6.pdf>

europa.eu/humandocs/PDFs/EPAR/glivec/241801en6.pdf

(glivec is the name used in Europe, don't ask why, but it is the same

drug and the same packaging).

Marcos.

On 6/26/07, barbara <barb521comcast (DOT) <mailto:barb521%40comcast.net> net>

wrote:

>

> Mine is delivered via mail order and during the summer, it's in a

Styrofoam

> box with an ice pack.

>

> Barbara Hundley

>

> _____

>

> From: groups (DOT) <mailto:%40> com

[mailto:groups (DOT) <mailto:%40> com] On Behalf Of

Tracey

> Sent: Tuesday, June 26, 2007 9:41 PM

> groups (DOT) <mailto:%40> com

> Subject: Re: [ ] Traveling with Gleevec

>

> That's a good point Marcos. On top of that, wouldn't you say that

> many of our houses can get warmer than 86 degrees in the summer? I'm

> sure not everyone has air conditioning. And what about the people

> who deliver the drugs to the pharmacies, do they have the drug

> temperature controlled? I doubt it.

>

> Tracey

>

> > >

> > > > I'm planning a trip to a remote area of France

> > > > where the temperatures

> > > > are often in the high 90's. The temperature

> > > > tolerance of Gleevec is

> > > > between 59 and 86. I would be traveling on hot

> > > > non air conditioned

> > > > trains, in hot train stations, and sometimes

> > > > hot airports. I was

> > > > thinking of ways to keep the Gleevec safe, but

> > > > haven't come up with

> > > > anything very pracitical. The best I can come

> > > > up with is carrying the

> > > > Gleevec in an insulated lunch bag with some ice

> > > > and a thermometer. I

> > > > would need to check the temp often to make sure

> > > > it wasn't too hot or

> > > > too cold. This plan has risks of being caught

> > > > in an unexpected

> > > > situation with no access to ice. My Dr. says

> > > > that being without daily

> > > > Gleevec at this time could be extremely

> > > > dangerous for me. I am

> > > > thinking of canceling the trip. Any

> > > > suggestions would be appreciated.

> > > >

> > > > Thanks,

> > > >

> > >

> > > ~Stacey Thacker~

> > >

> > > __________________________________________________________

> > > Park yourself in front of a world of choices in alternative

> vehicles.

> > > Visit the Auto Green Center.

> > > http://autos. <http://autos. <http://autos./green_center/>

/green_center/>

>

> /green_center/

> > >

> >

> > --

> > Marcos Perreau Guimaraes

> > Suppes Brain Lab

> > Ventura Hall - CSLI

> > Stanford University

> > 220 Panama street

> > Stanford CA 94305-4101

> > 650 329 9920 x 305

> > 650 630 5015 (cell)

> > marcospg@...

> > montereyunderwater@...

> > www.stanford.edu/~marcospg/

> >

June 27, 2007

That's a real ugly link I posted. Here's a tiny version :

http://tinyurl.com/ytwcq6

Marcos.

On 6/26/07, Zavie miller <zmiller@...> wrote:

>

> Hi Marcos,

>

> Thank you for digging out that refererence.

>

> There are very few medications that are very sensitive to temperature.

>

> Zavie

>

> Zavie (age 69)

> 67 Shoreham Avenue

> Ottawa, Canada, K2G 3X3

> dxd AUG/99

> INF OCT/99 to FEB/00, CHF

> No meds FEB/00 to JAN/01

> Gleevec since MAR/27/01 (400 mg)

> CCR SEP/01. #102 in Zero Club

> 2.8 log reduction Sep/05

> 3.0 log reduction Jan/06

> 2.9 log reduction Feb/07

> e-mail: zmiller@...

> Tel: 613-726-1117

> Fax: 309-296-0807

> Cell: 613-202-0204

> ID: zaviem

> _____

>

> From: [mailto: ] On Behalf Of Marcos

> Perreau Guimaraes

> Sent: June 26, 2007 10:56 PM

>

> Subject: Re: [ ] Traveling with Gleevec

>

> Sounds as consistent as PCR testing

> I found a 2004 document from the European Medicines Agency that says, I

> quote :

> " Stability

> Preliminary investigations have established the main degradation

> pathways , e.g. oxidation to N-oxide under oxidative stress

> conditions. Degradation was not observed after storage at high

> temperatures (100ºC). "

>

> 100C is 212F, if you place gets that warm call the firefighters

>

> Reference :

> http://www.emea.

> <http://www.emea.europa.eu/humandocs/PDFs/EPAR/glivec/241801en6.pdf>

> europa.eu/humandocs/PDFs/EPAR/glivec/241801en6.pdf

>

> (glivec is the name used in Europe, don't ask why, but it is the same

> drug and the same packaging).

> Marcos.

>

June 27, 2007

Hi ,

I don't know what is your budget or how long your stay is, but if you

are still concerned by keeping the pills at room temperature, a

solution would be to rent a car with ac from wherever the plane puts

you. From Paris, it should be about like driving from SF to LA. You

can also take a plane or a TGV to Bordeaux and rent a car there. When

I was still living in Paris I would have had doubts about how much

safety driving a car in France adds, but road fatalities have been cut

by half since I left so it must have improved.

I wish you a good time there.

Marcos.

On 6/26/07, lightday63 <lightday63@...> wrote:

>

> Hi Marcos -

> Thanks for getting back to me. I talked to the Novartis Company that

> makes Gleevec. They said once the drug goes outside these two

> temperature limits (59 and 86) it's effectivess is compromised or

> even destroyed.

> I've made this trip many times in the past. It's a coastal resort

> about 10 miles from Soulac Sur Mer. The trains to this city are not

> air conditioned. One time on the way to Soulac, the train was

> stalled for about 45 minutes and it really got hot. There is no

> dining car with ice, etc.

>

> > >

> > > I'm planning a trip to a remote area of France where the

> temperatures

> > > are often in the high 90's. The temperature tolerance of Gleevec

> is

> > > between 59 and 86. I would be traveling on hot non air conditioned

> > > trains, in hot train stations, and sometimes hot airports. I was

> > > thinking of ways to keep the Gleevec safe, but haven't come up

> with

> > > anything very pracitical. The best I can come up with is carrying

> the

> > > Gleevec in an insulated lunch bag with some ice and a

> thermometer. I

> > > would need to check the temp often to make sure it wasn't too hot

> or

> > > too cold. This plan has risks of being caught in an unexpected

> > > situation with no access to ice. My Dr. says that being without

> daily

> > > Gleevec at this time could be extremely dangerous for me. I am

> > > thinking of canceling the trip. Any suggestions would be

> appreciated.

> > >

> > > Thanks,

> > >

> >

> > --

> > Marcos Perreau Guimaraes

> > Suppes Brain Lab

> > Ventura Hall - CSLI

> > Stanford University

> > 220 Panama street

> > Stanford CA 94305-4101

> > 650 329 9920 x 305

> > 650 630 5015 (cell)

> > marcospg@...

> > montereyunderwater@...

> > www.stanford.edu/~marcospg/

> >

June 27, 2007

Hi Marcos,

Thanks for all your ideas and research. My budget doesn't permit car

rental. That's why I'm stuck with the train after flying into

Bordeaux.

The temperature range from your research is very impressive, but

still leaves me womdering how Novartis came up with something so

different.

> > > >

> > > > I'm planning a trip to a remote area of France where the

> > temperatures

> > > > are often in the high 90's. The temperature tolerance of

Gleevec

> > is

> > > > between 59 and 86. I would be traveling on hot non air

conditioned

> > > > trains, in hot train stations, and sometimes hot airports. I

was

> > > > thinking of ways to keep the Gleevec safe, but haven't come up

> > with

> > > > anything very pracitical. The best I can come up with is

carrying

> > the

> > > > Gleevec in an insulated lunch bag with some ice and a

> > thermometer. I

> > > > would need to check the temp often to make sure it wasn't too

hot

> > or

> > > > too cold. This plan has risks of being caught in an unexpected

> > > > situation with no access to ice. My Dr. says that being

without

> > daily

> > > > Gleevec at this time could be extremely dangerous for me. I am

> > > > thinking of canceling the trip. Any suggestions would be

> > appreciated.

> > > >

> > > > Thanks,

> > > >

> > >

> > > --

> > > Marcos Perreau Guimaraes

> > > Suppes Brain Lab

> > > Ventura Hall - CSLI

> > > Stanford University

> > > 220 Panama street

> > > Stanford CA 94305-4101

> > > 650 329 9920 x 305

> > > 650 630 5015 (cell)

> > > marcospg@

> > > montereyunderwater@

> > > www.stanford.edu/~marcospg/

> > >

June 27, 2007

Who is your supplier I get same thing,big box for so little.

Re: [ ] Traveling with Gleevec

That's a good point Marcos. On top of that, wouldn't you say that

many of our houses can get warmer than 86 degrees in the summer? I'm

sure not everyone has air conditioning. And what about the people

who deliver the drugs to the pharmacies, do they have the drug

temperature controlled? I doubt it.

Tracey

> >

> > > I'm planning a trip to a remote area of France

> > > where the temperatures

> > > are often in the high 90's. The temperature

> > > tolerance of Gleevec is

> > > between 59 and 86. I would be traveling on hot

> > > non air conditioned

> > > trains, in hot train stations, and sometimes

> > > hot airports. I was

> > > thinking of ways to keep the Gleevec safe, but

> > > haven't come up with

> > > anything very pracitical. The best I can come

> > > up with is carrying the

> > > Gleevec in an insulated lunch bag with some ice

> > > and a thermometer. I

> > > would need to check the temp often to make sure

> > > it wasn't too hot or

> > > too cold. This plan has risks of being caught

> > > in an unexpected

> > > situation with no access to ice. My Dr. says

> > > that being without daily

> > > Gleevec at this time could be extremely

> > > dangerous for me. I am

> > > thinking of canceling the trip. Any

> > > suggestions would be appreciated.

> > >

> > > Thanks,

> > >

> >

> > ~Stacey Thacker~

> >

> > ____________ _________ _________ _________ _________ _________ _

> > Park yourself in front of a world of choices in alternative

vehicles.

> > Visit the Auto Green Center.

> > http://autos. <http://autos. / green_center/>

/green_ center/

> >

>

> --

> Marcos Perreau Guimaraes

> Suppes Brain Lab

> Ventura Hall - CSLI

> Stanford University

> 220 Panama street

> Stanford CA 94305-4101

> 650 329 9920 x 305

> 650 630 5015 (cell)

> marcospg@...

> montereyunderwater@ ...

> www.stanford. edu/~marcospg/

>

June 27, 2007

Hi Marcos,

I'm taking the research you found to my Dr. and pharmacist and see if

they will talk to the Novartis people about it. If this research is

accurate, I see no reason to be concerned about temperature.

> >

> > Hi Marcos,

> >

> > Thank you for digging out that refererence.

> >

> > There are very few medications that are very sensitive to

temperature.

> >

> > Zavie

> >

> > Zavie (age 69)

> > 67 Shoreham Avenue

> > Ottawa, Canada, K2G 3X3

> > dxd AUG/99

> > INF OCT/99 to FEB/00, CHF

> > No meds FEB/00 to JAN/01

> > Gleevec since MAR/27/01 (400 mg)

> > CCR SEP/01. #102 in Zero Club

> > 2.8 log reduction Sep/05

> > 3.0 log reduction Jan/06

> > 2.9 log reduction Feb/07

> > e-mail: zmiller@...

> > Tel: 613-726-1117

> > Fax: 309-296-0807

> > Cell: 613-202-0204

> > ID: zaviem

> > _____

> >

> > From: [mailto: ] On

Behalf Of Marcos

> > Perreau Guimaraes

> > Sent: June 26, 2007 10:56 PM

> >

> > Subject: Re: [ ] Traveling with Gleevec

> >

> > Sounds as consistent as PCR testing

> > I found a 2004 document from the European Medicines Agency that

says, I

> > quote :

> > " Stability

> > Preliminary investigations have established the main degradation

> > pathways , e.g. oxidation to N-oxide under oxidative stress

> > conditions. Degradation was not observed after storage at high

> > temperatures (100ºC). "

> >

> > 100C is 212F, if you place gets that warm call the firefighters

> >

> > Reference :

> > http://www.emea.

> >

<http://www.emea.europa.eu/humandocs/PDFs/EPAR/glivec/241801en6.pdf>

> > europa.eu/humandocs/PDFs/EPAR/glivec/241801en6.pdf

> >

> > (glivec is the name used in Europe, don't ask why, but it is the

same

> > drug and the same packaging).

> > Marcos.

> >

>

June 27, 2007

,

You may (or not) have a hard time getting strait answers from Novartis, for

liability fear. You may want to email one of the big Dr, like Dr Drucker.

From what I have read here he is good at responding.

Marcos.

On 6/27/07, lightday63 <lightday63@...> wrote:

>

> Hi Marcos,

> I'm taking the research you found to my Dr. and pharmacist and see if

> they will talk to the Novartis people about it. If this research is

> accurate, I see no reason to be concerned about temperature.

>

> > >

> > > Hi Marcos,

> > >

> > > Thank you for digging out that refererence.

> > >

> > > There are very few medications that are very sensitive to

> temperature.

> > >

> > > Zavie

> > >

> > > Zavie (age 69)

> > > 67 Shoreham Avenue

> > > Ottawa, Canada, K2G 3X3

> > > dxd AUG/99

> > > INF OCT/99 to FEB/00, CHF

> > > No meds FEB/00 to JAN/01

> > > Gleevec since MAR/27/01 (400 mg)

> > > CCR SEP/01. #102 in Zero Club

> > > 2.8 log reduction Sep/05

> > > 3.0 log reduction Jan/06

> > > 2.9 log reduction Feb/07

> > > e-mail: zmiller@...

>

> > > Tel: 613-726-1117

> > > Fax: 309-296-0807

> > > Cell: 613-202-0204

> > > ID: zaviem

> > > _____

> > >

> > > From: <%40> [mailto:

> <%40>] On

> Behalf Of Marcos

> > > Perreau Guimaraes

> > > Sent: June 26, 2007 10:56 PM

> > > <%40>

> > > Subject: Re: [ ] Traveling with Gleevec

> > >

> > > Sounds as consistent as PCR testing

> > > I found a 2004 document from the European Medicines Agency that

> says, I

> > > quote :

> > > " Stability

> > > Preliminary investigations have established the main degradation

> > > pathways , e.g. oxidation to N-oxide under oxidative stress

> > > conditions. Degradation was not observed after storage at high

> > > temperatures (100ºC). "

> > >

> > > 100C is 212F, if you place gets that warm call the firefighters

> > >

> > > Reference :

> > > http://www.emea.

> > >

> <http://www.emea.europa.eu/humandocs/PDFs/EPAR/glivec/241801en6.pdf>

> > > europa.eu/humandocs/PDFs/EPAR/glivec/241801en6.pdf

> > >

> > > (glivec is the name used in Europe, don't ask why, but it is the

> same

> > > drug and the same packaging).

> > > Marcos.

> > >

> >

>

--

Marcos Perreau Guimaraes

Suppes Brain Lab

Ventura Hall - CSLI

Stanford University

220 Panama street

Stanford CA 94305-4101

650 329 9920 x 305

650 630 5015 (cell)

marcospg@...

montereyunderwater@...

www.stanford.edu/~marcospg/

June 27, 2007

Marcos -

I just joined this group and am not familiar with Dr. Drucker. Do you

have his e-mail address?

> > > >

> > > > Hi Marcos,

> > > >

> > > > Thank you for digging out that refererence.

> > > >

> > > > There are very few medications that are very sensitive to

> > temperature.

> > > >

> > > > Zavie

> > > >

> > > > Zavie (age 69)

> > > > 67 Shoreham Avenue

> > > > Ottawa, Canada, K2G 3X3

> > > > dxd AUG/99

> > > > INF OCT/99 to FEB/00, CHF

> > > > No meds FEB/00 to JAN/01

> > > > Gleevec since MAR/27/01 (400 mg)

> > > > CCR SEP/01. #102 in Zero Club

> > > > 2.8 log reduction Sep/05

> > > > 3.0 log reduction Jan/06

> > > > 2.9 log reduction Feb/07

> > > > e-mail: zmiller@

> >

> > > > Tel: 613-726-1117

> > > > Fax: 309-296-0807

> > > > Cell: 613-202-0204

> > > > ID: zaviem

> > > > _____

> > > >

> > > > From: <%40> [mailto:

> > <%40>] On

> > Behalf Of Marcos

> > > > Perreau Guimaraes

> > > > Sent: June 26, 2007 10:56 PM

> > > > <%40>

> > > > Subject: Re: [ ] Traveling with Gleevec

> > > >

> > > > Sounds as consistent as PCR testing

> > > > I found a 2004 document from the European Medicines Agency

that

> > says, I

> > > > quote :

> > > > " Stability

> > > > Preliminary investigations have established the main

degradation

> > > > pathways , e.g. oxidation to N-oxide under oxidative stress

> > > > conditions. Degradation was not observed after storage at high

> > > > temperatures (100ºC). "

> > > >

> > > > 100C is 212F, if you place gets that warm call the

firefighters

> > > >

> > > > Reference :

> > > > http://www.emea.

> > > >

> >

<http://www.emea.europa.eu/humandocs/PDFs/EPAR/glivec/241801en6.pdf>

> > > > europa.eu/humandocs/PDFs/EPAR/glivec/241801en6.pdf

> > > >

> > > > (glivec is the name used in Europe, don't ask why, but it is

the

> > same

> > > > drug and the same packaging).

> > > > Marcos.

> > > >

> > >

> >

>

> --

> Marcos Perreau Guimaraes

> Suppes Brain Lab

> Ventura Hall - CSLI

> Stanford University

> 220 Panama street

> Stanford CA 94305-4101

> 650 329 9920 x 305

> 650 630 5015 (cell)

> marcospg@...

> montereyunderwater@...

> www.stanford.edu/~marcospg/

>

June 27, 2007

I never contacted him myself, maybe somebody who did will chime in. Here's

his page and email at OHSU :

http://www.ohsu.edu/ohsuedu/healthcare/hemonc/faculty/druker.cfm

Marcos.

On 6/27/07, lightday63 <lightday63@...> wrote:

>

> Marcos -

> I just joined this group and am not familiar with Dr. Drucker. Do you

> have his e-mail address?

>

> > > > >

> > > > > Hi Marcos,

> > > > >

> > > > > Thank you for digging out that refererence.

> > > > >

> > > > > There are very few medications that are very sensitive to

> > > temperature.

> > > > >

> > > > > Zavie

> > > > >

> > > > > Zavie (age 69)

> > > > > 67 Shoreham Avenue

> > > > > Ottawa, Canada, K2G 3X3

> > > > > dxd AUG/99

> > > > > INF OCT/99 to FEB/00, CHF

> > > > > No meds FEB/00 to JAN/01

> > > > > Gleevec since MAR/27/01 (400 mg)

> > > > > CCR SEP/01. #102 in Zero Club

> > > > > 2.8 log reduction Sep/05

> > > > > 3.0 log reduction Jan/06

> > > > > 2.9 log reduction Feb/07

> > > > > e-mail: zmiller@

> > >

> > > > > Tel: 613-726-1117

> > > > > Fax: 309-296-0807

> > > > > Cell: 613-202-0204

> > > > > ID: zaviem

> > > > > _____

> > > > >

> > > > > From:

<%40><%40> [mailto:

> > > <%40><%40>] On

> > > Behalf Of Marcos

> > > > > Perreau Guimaraes

> > > > > Sent: June 26, 2007 10:56 PM

> > > > >

<%40><%40>

> > > > > Subject: Re: [ ] Traveling with Gleevec

> > > > >

> > > > > Sounds as consistent as PCR testing

> > > > > I found a 2004 document from the European Medicines Agency

> that

> > > says, I

> > > > > quote :

> > > > > " Stability

> > > > > Preliminary investigations have established the main

> degradation

> > > > > pathways , e.g. oxidation to N-oxide under oxidative stress

> > > > > conditions. Degradation was not observed after storage at high

> > > > > temperatures (100ºC). "

> > > > >

> > > > > 100C is 212F, if you place gets that warm call the

> firefighters

> > > > >

> > > > > Reference :

> > > > > http://www.emea.

> > > > >

> > >

> <http://www.emea.europa.eu/humandocs/PDFs/EPAR/glivec/241801en6.pdf>

> > > > > europa.eu/humandocs/PDFs/EPAR/glivec/241801en6.pdf

> > > > >

> > > > > (glivec is the name used in Europe, don't ask why, but it is

> the

> > > same

> > > > > drug and the same packaging).

> > > > > Marcos.

> > > > >

> > > >

> > >

> >

> > --

> > Marcos Perreau Guimaraes

> > Suppes Brain Lab

> > Ventura Hall - CSLI

> > Stanford University

> > 220 Panama street

> > Stanford CA 94305-4101

> > 650 329 9920 x 305

> > 650 630 5015 (cell)

> > marcospg@...

> > montereyunderwater@...

> > www.stanford.edu/~marcospg/

> >

June 28, 2007

Medco

Barbara Hundley

_____

From: [mailto: ] On Behalf Of

Shipley

Sent: Wednesday, June 27, 2007 11:50 AM

Subject: Re: [ ] Traveling with Gleevec

Who is your supplier I get same thing,big box for so little.

Re: [ ] Traveling with Gleevec

That's a good point Marcos. On top of that, wouldn't you say that

many of our houses can get warmer than 86 degrees in the summer? I'm

sure not everyone has air conditioning. And what about the people

who deliver the drugs to the pharmacies, do they have the drug

temperature controlled? I doubt it.

Tracey

> >

> > > I'm planning a trip to a remote area of France

> > > where the temperatures

> > > are often in the high 90's. The temperature

> > > tolerance of Gleevec is

> > > between 59 and 86. I would be traveling on hot

> > > non air conditioned

> > > trains, in hot train stations, and sometimes

> > > hot airports. I was

> > > thinking of ways to keep the Gleevec safe, but

> > > haven't come up with

> > > anything very pracitical. The best I can come

> > > up with is carrying the

> > > Gleevec in an insulated lunch bag with some ice

> > > and a thermometer. I

> > > would need to check the temp often to make sure

> > > it wasn't too hot or

> > > too cold. This plan has risks of being caught

> > > in an unexpected

> > > situation with no access to ice. My Dr. says

> > > that being without daily

> > > Gleevec at this time could be extremely

> > > dangerous for me. I am

> > > thinking of canceling the trip. Any

> > > suggestions would be appreciated.

> > >

> > > Thanks,

> > >

> >

> > ~Stacey Thacker~

> >

> > ____________ _________ _________ _________ _________ _________ _

> > Park yourself in front of a world of choices in alternative

vehicles.

> > Visit the Auto Green Center.

> > http://autos. <http://autos. / green_center/>

/green_ center/

> >

>

> --

> Marcos Perreau Guimaraes

> Suppes Brain Lab

> Ventura Hall - CSLI

> Stanford University

> 220 Panama street

> Stanford CA 94305-4101

> 650 329 9920 x 305

> 650 630 5015 (cell)

> marcospg@...

> montereyunderwater@ ...

> www.stanford. edu/~marcospg/

>

June 28, 2007

Hi Marcos,

I just talked to my Dr. today. He has concluded that the risk of the

gleevec being damaged by high temps is very low. And even if it were

to be damaged, the risk to my health from taking damaged gleevec for

a few days would also be very low. So I'm off to France!

> > > > > >

> > > > > > Hi Marcos,

> > > > > >

> > > > > > Thank you for digging out that refererence.

> > > > > >

> > > > > > There are very few medications that are very sensitive to

> > > > temperature.

> > > > > >

> > > > > > Zavie

> > > > > >

> > > > > > Zavie (age 69)

> > > > > > 67 Shoreham Avenue

> > > > > > Ottawa, Canada, K2G 3X3

> > > > > > dxd AUG/99

> > > > > > INF OCT/99 to FEB/00, CHF

> > > > > > No meds FEB/00 to JAN/01

> > > > > > Gleevec since MAR/27/01 (400 mg)

> > > > > > CCR SEP/01. #102 in Zero Club

> > > > > > 2.8 log reduction Sep/05

> > > > > > 3.0 log reduction Jan/06

> > > > > > 2.9 log reduction Feb/07

> > > > > > e-mail: zmiller@

> > > >

> > > > > > Tel: 613-726-1117

> > > > > > Fax: 309-296-0807

> > > > > > Cell: 613-202-0204

> > > > > > ID: zaviem

> > > > > > _____

> > > > > >

> > > > > > From: <%40><%

40> [mailto:

> > > > <%40><%

40>] On

> > > > Behalf Of Marcos

> > > > > > Perreau Guimaraes

> > > > > > Sent: June 26, 2007 10:56 PM

> > > > > > <%40><%

40>

> > > > > > Subject: Re: [ ] Traveling with Gleevec

> > > > > >

> > > > > > Sounds as consistent as PCR testing

> > > > > > I found a 2004 document from the European Medicines Agency

> > that

> > > > says, I

> > > > > > quote :

> > > > > > " Stability

> > > > > > Preliminary investigations have established the main

> > degradation

> > > > > > pathways , e.g. oxidation to N-oxide under oxidative

stress

> > > > > > conditions. Degradation was not observed after storage at

high

> > > > > > temperatures (100ºC). "

> > > > > >

> > > > > > 100C is 212F, if you place gets that warm call the

> > firefighters

> > > > > >

> > > > > > Reference :

> > > > > > http://www.emea.

> > > > > >

> > > >

> >

<http://www.emea.europa.eu/humandocs/PDFs/EPAR/glivec/241801en6.pdf>

> > > > > > europa.eu/humandocs/PDFs/EPAR/glivec/241801en6.pdf

> > > > > >

> > > > > > (glivec is the name used in Europe, don't ask why, but it

is

> > the

> > > > same

> > > > > > drug and the same packaging).

> > > > > > Marcos.

> > > > > >

> > > > >

> > > >

> > >

> > > --

> > > Marcos Perreau Guimaraes

> > > Suppes Brain Lab

> > > Ventura Hall - CSLI

> > > Stanford University

> > > 220 Panama street

> > > Stanford CA 94305-4101

> > > 650 329 9920 x 305

> > > 650 630 5015 (cell)

> > > marcospg@

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Re: Traveling with Gleevec

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