Guest guest Posted June 24, 2007 Report Share Posted June 24, 2007 I am curious about Ibupropen and BMS. My ALT test was a little high and I was curiuos if the combination of these two might be why. Tracey <traceyincanada@...> wrote: Hi Everyone, Chris's recent experience has caused me to go back and check a few drugs to see how they metabolize and I have found some interesting things. For anyone who wants to read the technical information regarding Gleevec, you can find a good synopsis here: http://www.drugs.com/pro/gleevec.html Where it lists the drugs that may have their plasma levels altered by Gleevec you'll see that Acetaminophen (Tylenol) is specifically listed. We've known for years that we weren't supposed to take Tylenol because it can " compete with Gleevec for metabolization " but this was the first time I read that when taken together, the plasma level for Tylenol can actually increase. So in other words, a 500mg pill of Tylenol, could potentially be double or triple that in your system. Having higher levels of Acetaminophen in your blood will obviously make the risk of toxicity greater which is something we want to avoid if at all possible. Another interesting site I found: http://www.medscape.com/viewarticle/444804_5 Describes the CYP3A4 isoenzyme (the one that Gleevec uses for metabolization). It says that about 50% of drugs use this isoenzyme including exogenous corticosteroids. I often use Hydrocortisone for eczema but I never thought that it could interact with Gleevec. I'm not sure how much cream would need to be used in order to cause a significant interaction, but it's something to think about I guess. Also of note, I found that plasma levels of Diphenhydramine Hydrochloride (AKA Benadryl), can be increased when taken with Gleevec because the Benadryl uses the P450 2D6 isoenzyme to metabolize which Gleevec can inhibit. http://www.nhtsa.dot.gov/PEOPLE/injury/research/job185drugs/diphenhydr amine.htm The theraputic range for Benadryl is fairly wide so I'm not sure how significant this finding is but it's made me realize that when it comes to taking a dose of Benadryl, size can matter and smaller is better I guess the moral of my story is that it's very important to check out each drug we take to know exactly how or if it will interact with Gleevec. Tracey --------------------------------- Pinpoint customers who are looking for what you sell. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 24, 2007 Report Share Posted June 24, 2007 Hi , According to http://www.drugs.com/pro/ibuprofen.html it is possible that the Ibuprofen could cause an elevation in ALT. If you scroll down to where it talks about hepatic events, you'll see that 1% of patients in clinical trials using NSAID's (which Ibuprofen is one of) did experience an elevation in ALT and/or AST. So although rare, it is possible. Also, if you look at http://www.drugs.com/ppa/dasatinib.html , you'll see that the information for Sprycel mentions that elevated transaminases have been noted in patients so it could be from the Sprycel as well. A slight elevation usually isn't anything to worry about. It's when it gets to be double, triple and quadruple the upper limit of normal that you really need to pay attention. Take care, Tracey > > I am curious about Ibupropen and BMS. My ALT test was a little high and I was curiuos if the combination of these two might be why. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 24, 2007 Report Share Posted June 24, 2007 Thank you so much for the information. It's not there yet, but my counts are always so normal, I was a little concerned. I take about 800 mg at night before bed if I have physically pressed myself, if I don't the next day could be very rough, i.e. muscle and joint pain. I also wondered if pain in the ankles are common fr anyone? Sometimes my feet and ankles get so sore. Tracey <traceyincanada@...> wrote: Hi , According to http://www.drugs.com/pro/ibuprofen.html it is possible that the Ibuprofen could cause an elevation in ALT. If you scroll down to where it talks about hepatic events, you'll see that 1% of patients in clinical trials using NSAID's (which Ibuprofen is one of) did experience an elevation in ALT and/or AST. So although rare, it is possible. Also, if you look at http://www.drugs.com/ppa/dasatinib.html , you'll see that the information for Sprycel mentions that elevated transaminases have been noted in patients so it could be from the Sprycel as well. A slight elevation usually isn't anything to worry about. It's when it gets to be double, triple and quadruple the upper limit of normal that you really need to pay attention. Take care, Tracey > > I am curious about Ibupropen and BMS. My ALT test was a little high and I was curiuos if the combination of these two might be why. > --------------------------------- 8:00? 8:25? 8:40? Find a flick in no time with the Search movie showtime shortcut. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 25, 2007 Report Share Posted June 25, 2007 I am in the blast stage and pain and ankle joint is always pain for me. As for today my count is 40.0% which means it is too low.I am still on spycell and i do not know what is reducing the count so low. Any help please form anyone ________________________________________________________________________________\ ____ oneSearch: Finally, mobile search that gives answers, not web links. http://mobile./mobileweb/onesearch?refer=1ONXIC Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 25, 2007 Report Share Posted June 25, 2007 I don't understand. My last blood counts were normal, accept my ALT was high but minimally so (45), and I too am on Sprycell but I have been experiencing this pain for the last month. How long have you been in blast and when you say your count was low by what are you referring to? pet ade <petbenin@...> wrote: I am in the blast stage and pain and ankle joint is always pain for me. As for today my count is 40.0% which means it is too low.I am still on spycell and i do not know what is reducing the count so low. Any help please form anyone __________________________________________________________ oneSearch: Finally, mobile search that gives answers, not web links. http://mobile./mobileweb/onesearch?refer=1ONXIC --------------------------------- Ready for the edge of your seat? Check out tonight's top picks on TV. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 25, 2007 Report Share Posted June 25, 2007 Hi , Pain of any kind could be for any reason. It doesn't necessarily mean that Sprycel is at the root of it, or even CML for that matter. My ankle recently started hurting me as well, but I figured out that it was because of the way I was sitting on it in the garden and not anything ominous. After I stopped sitting on it like that, the pain went away. Don't worry about your ALT , 45 is barely even elevated. If there was anything going on with your liver, it would not only be much much higher but your ALP, bilirubin and AST would also be sky high. Take care, Tracey > I am in the blast stage and pain and ankle joint is > always pain for me. > > As for today my count is 40.0% which means it is too > low.I am still on spycell and i do not know what is > reducing the count so low. > > Any help please form anyone > > __________________________________________________________ > oneSearch: Finally, mobile search > that gives answers, not web links. > http://mobile./mobileweb/onesearch?refer=1ONXIC > > > > > > --------------------------------- > Ready for the edge of your seat? Check out tonight's top picks on TV. > > Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.