Re: Does anyone know if monocytosis is worrisome or not?

[Guest guest]

Hi Grace,

Welcome to the group. It's hard to say if your monocytosis is a

problem or not. The first question that I would ask is do you have

some kind of viral infection such as Mono or a childhood illness like

mumps or measles? These can make your monocytes go up. Another

possible reason for an increase in monocytes is a parasitic

infection.

When are you scheduled for your next blood test. Try not to worry

over one blood test result, it's a trend that will tell you if there

is something going on or not. If your next test is higher then I

think you should try to figure out what is causing your monocytes to

rise.

The bottom line is that if your monocytes are indeed on the rise, it

might not have anything to do with the CML but you do need to find

out what is going on.

The other issue I would discuss with your doctor is why is she

keeping you on Gleevec if you're still not in CCR after 3 years?

There are a variety of options that are available to you now and if

Gleevec isn't working you should switch to something that will work.

Let us know what your next test says,

Tracey

dx Jan 2002

400mg Gleevec since Feb 2002

>

> Hi. I was diagnosed with CML three years ago; have been on Gleevec

> all that time - never reached 0% PH chromosome.

>

> I went for my checkup the other day, and my blood was checked via

> the " quickie " blood machine in the office. My monocytes are over

> 17% - something new, not a problem before. Total WBC is normal at

> this point.

>

> When the doctor came in, she said, " Are you still taking your

> Gleevec? " Well, of course I am. She stated that we have to see if

> the Gleevec is still working.

>

> Well, it always takes some time to get the PCR results, and I am

> wondering, is this monocytosis a problem or not? I do know that

> monocytes over 15% are supposed to be extremely high. Could

> monocytosis be a sign that the CML is becoming Gleevec resistant?

>

> Also, supposing Gleevec isn't working anymore, what else is there?

I

> tried Sprycel because of Gleevec side effects, but I developed

angina

> from the Sprycel (never had any heart issues before or since

> Sprycel).

>

> Grace

>

[Guest guest]

Hi! No, I don't have a viral infection or any infection that I'm

aware of. I certainly have been even more tired lately - which is

strange, considering that my hemoglobin and hematrocrit were actually

normal the other day. They are usually low because of the Gleevec.

Grace

> >

> > Hi. I was diagnosed with CML three years ago; have been on

Gleevec

> > all that time - never reached 0% PH chromosome.

> >

> > I went for my checkup the other day, and my blood was checked via

> > the " quickie " blood machine in the office. My monocytes are over

> > 17% - something new, not a problem before. Total WBC is normal

at

> > this point.

> >

> > When the doctor came in, she said, " Are you still taking your

> > Gleevec? " Well, of course I am. She stated that we have to see

if

> > the Gleevec is still working.

> >

> > Well, it always takes some time to get the PCR results, and I am

> > wondering, is this monocytosis a problem or not? I do know that

> > monocytes over 15% are supposed to be extremely high. Could

> > monocytosis be a sign that the CML is becoming Gleevec resistant?

> >

> > Also, supposing Gleevec isn't working anymore, what else is

there?

> I

> > tried Sprycel because of Gleevec side effects, but I developed

> angina

> > from the Sprycel (never had any heart issues before or since

> > Sprycel).

> >

> > Grace

> >

>