RE: Quantitative RT-PCR result

[Guest guest]

Hi ,

O!!! YIPPEEE!!!

Yes indeed you are PCRU. This is an outstanding result. It took you less

than 1 year to get here.

Zavie

Zavie (age 69)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.2 log reduction Jun/07

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 309-296-0807

Cell: 613-202-0204

ID: zaviem

_____

From: [mailto: ] On Behalf Of

cy_butterfly3

Sent: July 26, 2007 9:18 PM

Subject: [ ] Quantitative RT-PCR result

Hi,

I went to see my oncologist early July. I was diagnoised in early Aug

06 and have been on Gleevec since Sept 06. He ordered a Quantitative

RT-PCR Analysis. Today I called in to the doctor office to see if the

result is back. The nurse faxed me the result of " No BCR-ABL

translocation was detected in this sample " .

I have FISH tests done in Dec 06, Jan and April 07. They all came out

negative.

Am I in remission? Am I PCRU?

Please comments.

Thanks.

[Guest guest]

Zavie,

I am very happy and surprised with the result. I have a very fast

and good response to Gleevec. Is the Quantitative RT-PCR test the

final test of the disease? Is there any other tests after

Quantitative RT-PCR to be done?

Thanks.

>

> Hi ,

>

> O!!! YIPPEEE!!!

>

> Yes indeed you are PCRU. This is an outstanding result. It took

you less

> than 1 year to get here.

>

> Zavie

>

> Zavie (age 69)

> 67 Shoreham Avenue

> Ottawa, Canada, K2G 3X3

> dxd AUG/99

> INF OCT/99 to FEB/00, CHF

> No meds FEB/00 to JAN/01

> Gleevec since MAR/27/01 (400 mg)

> CCR SEP/01. #102 in Zero Club

> 2.8 log reduction Sep/05

> 3.0 log reduction Jan/06

> 2.9 log reduction Feb/07

> 3.2 log reduction Jun/07

> e-mail: zmiller@...

> Tel: 613-726-1117

> Fax: 309-296-0807

> Cell: 613-202-0204

> ID: zaviem

>

> _____

>

> From: [mailto: ] On Behalf

Of

> cy_butterfly3

> Sent: July 26, 2007 9:18 PM

>

> Subject: [ ] Quantitative RT-PCR result

>

> Hi,

> I went to see my oncologist early July. I was diagnoised in early

Aug

> 06 and have been on Gleevec since Sept 06. He ordered a

Quantitative

> RT-PCR Analysis. Today I called in to the doctor office to see if

the

> result is back. The nurse faxed me the result of " No BCR-ABL

> translocation was detected in this sample " .

>

> I have FISH tests done in Dec 06, Jan and April 07. They all came

out

> negative.

>

> Am I in remission? Am I PCRU?

>

> Please comments.

>

> Thanks.

>

>

>

>

>

[Guest guest]

hey everybody. i just got on this chat thing and it sounds like everybody is

benifiting from these new drugs. thats just wonderful!! congrats to all.

i started on gleevic when i was diagnosed in june of 95.not sure what my dose

was, but we knew within 2 months it wasn't working. i built a resistance to it

almost emediately. my bmb at this time was 87%. then i was put in a study in

omaha on a drug called sprycel. ever since my numbers have reduced to .05% is

that close enough to be in the zero club?

---------------------------------

Building a website is a piece of cake.

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[Guest guest]

Hi ,

Hi ,

Yes, the QRT-PCR is the most sensitive test we have today. You should be

able to live a normal and productive life with this result.

I firmly believe (HOPE) that we will see a cure for this disease within

10-20 years.

Zavie

Zavie (age 69)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.2 log reduction Jun/07

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 309-296-0807

Cell: 613-202-0204

ID: zaviem

_____

From: [mailto: ] On Behalf Of

cy_butterfly3

Sent: July 27, 2007 8:13 AM

Subject: Re: [ ] Quantitative RT-PCR result

Zavie,

I am very happy and surprised with the result. I have a very fast

and good response to Gleevec. Is the Quantitative RT-PCR test the

final test of the disease? Is there any other tests after

Quantitative RT-PCR to be done?

Thanks.

>

> Hi ,

>

> O!!! YIPPEEE!!!

>

> Yes indeed you are PCRU. This is an outstanding result. It took

you less

> than 1 year to get here.

>

> Zavie

>

> Zavie (age 69)

> 67 Shoreham Avenue

> Ottawa, Canada, K2G 3X3

> dxd AUG/99

> INF OCT/99 to FEB/00, CHF

> No meds FEB/00 to JAN/01

> Gleevec since MAR/27/01 (400 mg)

> CCR SEP/01. #102 in Zero Club

> 2.8 log reduction Sep/05

> 3.0 log reduction Jan/06

> 2.9 log reduction Feb/07

> 3.2 log reduction Jun/07

> e-mail: zmiller@...

> Tel: 613-726-1117

> Fax: 309-296-0807

> Cell: 613-202-0204

> ID: zaviem

>

> _____

>

> From: groups (DOT) <mailto:%40> com

[mailto:groups (DOT) <mailto:%40> com] On Behalf

Of

> cy_butterfly3

> Sent: July 26, 2007 9:18 PM

> groups (DOT) <mailto:%40> com

> Subject: [ ] Quantitative RT-PCR result

>

> Hi,

> I went to see my oncologist early July. I was diagnoised in early

Aug

> 06 and have been on Gleevec since Sept 06. He ordered a

Quantitative

> RT-PCR Analysis. Today I called in to the doctor office to see if

the

> result is back. The nurse faxed me the result of " No BCR-ABL

> translocation was detected in this sample " .

>

> I have FISH tests done in Dec 06, Jan and April 07. They all came

out

> negative.

>

> Am I in remission? Am I PCRU?

>

> Please comments.

>

> Thanks.

>

>

>

>

>

[Guest guest]

O!!! YIPPEEE!!!

Number 1081 in the Zero Club

Zavie

It sure is close enough. All you need is to achieve CCR to make it into the

club.

Zavie

Zavie (age 69)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.2 log reduction Jun/07

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 309-296-0807

Cell: 613-202-0204

ID: zaviem

_____

From: [mailto: ] On Behalf Of

Sent: July 27, 2007 8:23 AM

Subject: RE: [ ] Quantitative RT-PCR result

hey everybody. i just got on this chat thing and it sounds like everybody

is benifiting from these new drugs. thats just wonderful!! congrats to all.

i started on gleevic when i was diagnosed in june of 95.not sure what my

dose was, but we knew within 2 months it wasn't working. i built a

resistance to it almost emediately. my bmb at this time was 87%. then i was

put in a study in omaha on a drug called sprycel. ever since my numbers have

reduced to .05% is that close enough to be in the zero club?

---------------------------------

Building a website is a piece of cake.

Small Business gives you all the tools to get online.

[Guest guest]

what is ccr?

---------------------------------

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[Guest guest]

Complete Cyetogenic response. When the sample of

white blood cells are reviewed none exhibit the CML

characteristics/translocation.

--- <stephenraymoore@...> wrote:

> what is ccr?

>

> ---------------------------------

> Luggage? GPS? Comic books?

> Check out fitting gifts for grads at Search.

>

> [Non-text portions of this message have been

> removed]

>

>

________________________________________________________________________________\

____

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[Guest guest]

Hi ,

is correct; it stands for Complete Cytogenic Response.

I usually associate this term with the BMA or BMB test. BMA: Bone Marrow

Aspiration, BMB: Bone Marrow Biopsy.

With this test they examine 20 cells. If you are 0/20 by this test, you make

it into the Zero Club.

We know that you can be Zero via this test but not Zero with the more

sensitive tests (FISH, PCR).

We also know that even though you are Zero by the most sensitive RT-PCR test

and you stop taking Gleevec that you will eventually relapse.

I see the Zero Club as a club of HOPE. When we are first diagnosed, joining

the Zero Club is a milestone that you want to achieve. This is the first

indication that you will be able to live a pretty normal life even though

you still have that nasty CML bug in your system.

Zavie

Zavie (age 69)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.2 log reduction Jun/07

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 309-296-0807

Cell: 613-202-0204

ID: zaviem

_____

From: [mailto: ] On Behalf Of

Sent: July 27, 2007 9:17 AM

Subject: RE: [ ] Quantitative RT-PCR result

what is ccr?

---------------------------------

Luggage? GPS? Comic books?

Check out fitting gifts for grads at Search.

[Guest guest]

Hi ,

Are you saying that you were only on Gleevec for 2 months before you

were switched to Sprycel and that the only reason you were switched

to Sprycel was because the Gleevec wasn't working? That seems odd to

me since 2 months isn't a very long time to see how it will work.

Most doctors will wait at least 6 months or even a year before they

determine if a drug is working or not.

Tracey

--- In , <stephenraymoore@...>

wrote:

>

> hey everybody. i just got on this chat thing and it sounds like

everybody is benifiting from these new drugs. thats just wonderful!!

congrats to all.

> i started on gleevic when i was diagnosed in june of 95.not sure

what my dose was, but we knew within 2 months it wasn't working. i

built a resistance to it almost emediately. my bmb at this time was

87%. then i was put in a study in omaha on a drug called sprycel.

ever since my numbers have reduced to .05% is that close enough to be

in the zero club?

>

>

> ---------------------------------

> Building a website is a piece of cake.

> Small Business gives you all the tools to get online.

>

>

[Guest guest]

Is number 1081 for me or for fellow ? I think I had a

number assigned 1033 when I acheived zero on my FISH test in

December 06.

>

> O!!! YIPPEEE!!!

> Number 1081 in the Zero Club

> Zavie

>

>

> It sure is close enough. All you need is to achieve CCR to make it

into the

> club.

>

> Zavie

>

>

> Zavie (age 69)

> 67 Shoreham Avenue

> Ottawa, Canada, K2G 3X3

> dxd AUG/99

> INF OCT/99 to FEB/00, CHF

> No meds FEB/00 to JAN/01

> Gleevec since MAR/27/01 (400 mg)

> CCR SEP/01. #102 in Zero Club

> 2.8 log reduction Sep/05

> 3.0 log reduction Jan/06

> 2.9 log reduction Feb/07

> 3.2 log reduction Jun/07

> e-mail: zmiller@...

> Tel: 613-726-1117

> Fax: 309-296-0807

> Cell: 613-202-0204

> ID: zaviem

>

> _____

>

> From: [mailto: ] On Behalf

Of

>

> Sent: July 27, 2007 8:23 AM

>

> Subject: RE: [ ] Quantitative RT-PCR result

>

> hey everybody. i just got on this chat thing and it sounds like

everybody

> is benifiting from these new drugs. thats just wonderful!!

congrats to all.

> i started on gleevic when i was diagnosed in june of 95.not sure

what my

> dose was, but we knew within 2 months it wasn't working. i built a

> resistance to it almost emediately. my bmb at this time was 87%.

then i was

> put in a study in omaha on a drug called sprycel. ever since my

numbers have

> reduced to .05% is that close enough to be in the zero club?

>

> ---------------------------------

> Building a website is a piece of cake.

> Small Business gives you all the tools to get online.

>

>

[Guest guest]

thats what im sayin.

---------------------------------

Luggage? GPS? Comic books?

Check out fitting gifts for grads at Search.

[Guest guest]

Hi ,

is #1081 and you are #1033.

Zavie

Zavie (age 69)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.2 log reduction Jun/07

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 309-296-0807

Cell: 613-202-0204

ID: zaviem

_____

From: [mailto: ] On Behalf Of

cy_butterfly3

Sent: July 27, 2007 10:59 AM

Subject: Re: [ ] Quantitative RT-PCR result

Is number 1081 for me or for fellow ? I think I had a

number assigned 1033 when I acheived zero on my FISH test in

December 06.

>

> O!!! YIPPEEE!!!

> Number 1081 in the Zero Club

> Zavie

>

>

> It sure is close enough. All you need is to achieve CCR to make it

into the

> club.

>

> Zavie

>

>

> Zavie (age 69)

> 67 Shoreham Avenue

> Ottawa, Canada, K2G 3X3

> dxd AUG/99

> INF OCT/99 to FEB/00, CHF

> No meds FEB/00 to JAN/01

> Gleevec since MAR/27/01 (400 mg)

> CCR SEP/01. #102 in Zero Club

> 2.8 log reduction Sep/05

> 3.0 log reduction Jan/06

> 2.9 log reduction Feb/07

> 3.2 log reduction Jun/07

> e-mail: zmiller@...

> Tel: 613-726-1117

> Fax: 309-296-0807

> Cell: 613-202-0204

> ID: zaviem

>

> _____

>

> From: groups (DOT) <mailto:%40> com

[mailto:groups (DOT) <mailto:%40> com] On Behalf

Of

>

> Sent: July 27, 2007 8:23 AM

> groups (DOT) <mailto:%40> com

> Subject: RE: [ ] Quantitative RT-PCR result

>

> hey everybody. i just got on this chat thing and it sounds like

everybody

> is benifiting from these new drugs. thats just wonderful!!

congrats to all.

> i started on gleevic when i was diagnosed in june of 95.not sure

what my

> dose was, but we knew within 2 months it wasn't working. i built a

> resistance to it almost emediately. my bmb at this time was 87%.

then i was

> put in a study in omaha on a drug called sprycel. ever since my

numbers have

> reduced to .05% is that close enough to be in the zero club?

>

> ---------------------------------

> Building a website is a piece of cake.

> Small Business gives you all the tools to get online.

>

>

[Guest guest]

i dont care what number im called as long as im cancer free!

---------------------------------

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