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Major Molecular Response

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Hello all,

I'm a 29 year old white male who was diagnosed with CML in June 2006.

My WBC at the time was 335,000. That's down to normal and all my other

numbers are stable.

I was started on 400mg of Gleevec in July 2006 and stepped up to 600mg

in August 2006, which is my current dosage.

Here's a copy of my latest test:

bcr/abl,t(9;22) Translocation Quantitative Assay by RT-PCR

BCR/ABL SOURCE NOT SPEC

BCR/ABL QUANTITATIVE 1 Q POS

Positive: There is evidence of the bcr/abl fusion

trancript by RT-PCR analysis.

This result has been reviewed and approved by

D. B., M.D. [used initials to protect doc's identity]

Results are reported as a ratio of bcr/abl transcripts to

G6PDH transcripts.The limit of detection for this assay

is 1 in 1,000 cells.

BCR/ABL RATIO 0.00005

BCR/ABL PREVIOUS SOURCE NOT APPL

BCR/ABL PREVIOUS DRAW DT/TIME NOT APPL

BCR/ABL PREVIOUS QUANT 1 NOT APPL

BCR/ABL PREVIOUS QUANT RATIO NOT APPL

So, my doctor said that this means a Major Molecular Response. What

does that really mean? I know that's pretty good, but is that as good

as it can get?

Put it in laymans terms, please. I appreciate the help.

Sincerely,

Mark

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