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anyone on SKI 606

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Hi.. I haven't been in a group in a couple of years so I'm kinda

rusty. I was wondering in anyone on here is taking SKI606

(Bosutinib).

I started 800 mg of Gleevec in June 2002. My WBC count always

stayed above normal, but even with two years of " morning sickness " I

reached CR. Due to the increasing side effects my dosage was

reduced to 400 mg. All test were zero until Dec 2006 where I had

3.5% +Ph with a blood test. March 2007 blood work showed my count

as 2.5%. Finally only had to have a BM once a year YIPPEE!!! I was

back at MDA in June and the BM showed 70%... talk aboue a shock!!!

Needless to say I was back at MDA within two weeks for

prequalification test for the SKI trial. I go back this Friday for

my first dose 500 mg/day.

I've been told it's much stronger than Gleevec but with less side

effects... considering I had very strange / unknown side effect with

Gleevec I'm curious how this is going to go.

Would appreciate any information on SKI experiences.

I have noticed being more fatigued lately but just figured it was my

work schedule... but the past two weeks I have had nausea and an

upset stomach and i'm not taking gleevec or the new meds...

Any suggestions on if the stomach issues could be CML related?

Thanks

Jacki from Tx

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