Re: FISH Test scores 0%; BCR-ABL test at 5.8% - what does it mean?????

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From: [mailto: ] On Behalf Of

tinman1939new

Sent: September 28, 2007 3:50 PM

Subject: [ ] FISH Test scores 0%; BCR-ABL test at 5.8% - what does it

mean?????

I have my results (noted in the subject line), but because I am in the

process of changing doctors/cancer centers, I have not had an

opportunity to discuss the results with my practitioner. According to

the nurse I spoke to, however, the FISH test shows I am now

in " cytogenic remission. " Agreed? Tracey, can you weigh-in on this?

Also, I know the BCR-ABL is a molecular test - and that showed I am at

5.8%. This is the first molecular test I have taken, so I am not sure

how to interpret the results. Any feedback would be appreciated. The

results also show the following: Log% BCR-ABL: .77

[Guest guest]

Hi Tinman,

Congratulations, you've had a cytogenetic response if your FISH test

has shown 0%.

There isn't much you can interpret from your PCR since this is the

first one you've had and you don't have the baseline figure that the

lab uses to determine what a newly diagnosed patient would have. The

best thing you can do is wait for the next one (hopefully done at the

same lab) and then you can compare the two. You want to see the

number go down each time until it stabilizes at a low number.

I'm a little confused as to how you reported the number though. In

your subject line you say that the PCR was 5.8% but then at the end

of your post you say that it was 0.77. Can you clarify that?

Either way, it really wont' tell you much until you get another test

done to compare it with.

Congratulations though, it looks like you're on the right track.

Tracey

--- In , " tinman1939new " <tinman1939new@...>

wrote:

>

> I have my results (noted in the subject line), but because I am in

the

> process of changing doctors/cancer centers, I have not had an

> opportunity to discuss the results with my practitioner. According

to

> the nurse I spoke to, however, the FISH test shows I am now

> in " cytogenic remission. " Agreed? Tracey, can you weigh-in on

this?

>

> Also, I know the BCR-ABL is a molecular test - and that showed I am

at

> 5.8%. This is the first molecular test I have taken, so I am not

sure

> how to interpret the results. Any feedback would be appreciated.

The

> results also show the following: Log% BCR-ABL: .77

>

[Guest guest]

Tracey,

To clarify, this is what the molecular diagnostics report says under

" Results " :

5.8% BCR-ABL

Log % BCR-ABL: .77

What is your interpretation of the results?

TinMan

Tracey <traceyincanada@...> wrote:

Hi Tinman,

Congratulations, you've had a cytogenetic response if your FISH test

has shown 0%.

There isn't much you can interpret from your PCR since this is the

first one you've had and you don't have the baseline figure that the

lab uses to determine what a newly diagnosed patient would have. The

best thing you can do is wait for the next one (hopefully done at the

same lab) and then you can compare the two. You want to see the

number go down each time until it stabilizes at a low number.

I'm a little confused as to how you reported the number though. In

your subject line you say that the PCR was 5.8% but then at the end

of your post you say that it was 0.77. Can you clarify that?

Either way, it really wont' tell you much until you get another test

done to compare it with.

Congratulations though, it looks like you're on the right track.

Tracey

--- In , " tinman1939new " <tinman1939new@...>

wrote:

>

> I have my results (noted in the subject line), but because I am in

the

> process of changing doctors/cancer centers, I have not had an

> opportunity to discuss the results with my practitioner. According

to

> the nurse I spoke to, however, the FISH test shows I am now

> in " cytogenic remission. " Agreed? Tracey, can you weigh-in on

this?

>

> Also, I know the BCR-ABL is a molecular test - and that showed I am

at

> 5.8%. This is the first molecular test I have taken, so I am not

sure

> how to interpret the results. Any feedback would be appreciated.

The

> results also show the following: Log% BCR-ABL: .77

>

---------------------------------

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[Guest guest]

Hi Tinman,

It would appear to me that your PCR result is 5.8% and that your log

reduction is .77 which is a little less than 1 log. If I'm

interpreting your results correctly, you still have a bit of a way to

go before you get to the magical 3 log reduction.

Do you have a copy of your FISH test? If so, can you tell me how

many cells they analysed and if the result was indeed 0 because

usually the FISH will look at 200 cells and when you're zero on the

FISH, I would expect your PCR to be better than a 1 log reduction.

PCR tests are not always the best indicator of what's going on if you

aren't at about a 1.5 log reduction so if you are indeed FISH

negative then, that's the test I would focus on at this point. FISH

tests don't give false negatives (they can give false positives but

not false negatives) so if your FISH is zero, that's a good start and

with some more time, your PCR should come down.

Take care,

Tracey

> >

> > I have my results (noted in the subject line), but because I am

in

> the

> > process of changing doctors/cancer centers, I have not had an

> > opportunity to discuss the results with my practitioner.

According

> to

> > the nurse I spoke to, however, the FISH test shows I am now

> > in " cytogenic remission. " Agreed? Tracey, can you weigh-in on

> this?

> >

> > Also, I know the BCR-ABL is a molecular test - and that showed I

am

> at

> > 5.8%. This is the first molecular test I have taken, so I am not

> sure

> > how to interpret the results. Any feedback would be appreciated.

> The

> > results also show the following: Log% BCR-ABL: .77

> >

>

>

>

>

>

>

> ---------------------------------

> Check out the hottest 2008 models today at Autos.

>

>