Re: Food and other stuff inreracting with cml drugs

[Guest guest]

That wasn't the link I ad in mind, the more complete I found is :

http://www.ingentaconnect.com/content/tandf/txen/2002/00000032/00000006/art00001

Marcos.

On 6/28/07, Marcos Perreau Guimaraes <montereyunderwater@...> wrote:

> Following on the recent drug interaction thread I was wondering if we

> should also worry about other things we ingest interacting with our

> cml drug. I am looking for two kind of interactions :

>

> - First, things that interact with the drug being efficient at killing our bug

>

> - Second things that interact with side effects

>

> I didn't find much beside herbal products, here a link I found pretty

> exhaustive about things interacting with the CYP3A4 liver enzyme :

> http://www.cancerlynx.com/herbhealth.html

>

> If you would like to share sources of information I would be glad to

> have more things about usual foods (fruits, vegetables, meats, etc

> ...)

> Marcos.

>

--

Marcos Perreau Guimaraes

Suppes Brain Lab

Ventura Hall - CSLI

Stanford University

220 Panama street

Stanford CA 94305-4101

650 329 9920 x 305

650 630 5015 (cell)

marcospg@...

montereyunderwater@...

www.stanford.edu/~marcospg/

[Guest guest]

Hi Marcos,

Thanks for the links. I'm also very interested in this issue and

will do some more digging in the coming days. I think this is a very

important issue to consider seeing as we're going to be on Gleevec

(or some other such drug) for the rest of our lives. We obviously

wnat to be aware of anything that can interact.

Garlic was mentioned in the links you provided but I wonder if this

was referring to high dose garlic supplements or the usual clove that

many of us would use in cooking?

I'll let you know if I find anything else out that might be of

interest as I hope everyone else will do as well.

Tracey

> > Following on the recent drug interaction thread I was wondering

if we

> > should also worry about other things we ingest interacting with

our

> > cml drug. I am looking for two kind of interactions :

> >

> > - First, things that interact with the drug being efficient at

killing our bug

> >

> > - Second things that interact with side effects

> >

> > I didn't find much beside herbal products, here a link I found

pretty

> > exhaustive about things interacting with the CYP3A4 liver enzyme :

> > http://www.cancerlynx.com/herbhealth.html

> >

> > If you would like to share sources of information I would be glad

to

> > have more things about usual foods (fruits, vegetables, meats, etc

> > ...)

> > Marcos.

> >

>

>

> --

> Marcos Perreau Guimaraes

> Suppes Brain Lab

> Ventura Hall - CSLI

> Stanford University

> 220 Panama street

> Stanford CA 94305-4101

> 650 329 9920 x 305

> 650 630 5015 (cell)

> marcospg@...

> montereyunderwater@...

> www.stanford.edu/~marcospg/

>

[Guest guest]

Some drugs notices with similar pathways interactions than our drugs

(digested by p450 enzymes like CYP3xy, x=A,B,.., y=1,2,3,4) mention

than taking the pills with a rich meals (fatty, heavy in proteins or

calories) can increase the drug plasma level 6 fold, some other drugs

notices say it can decrease the plasma level of the drug. For those in

contact with the top league cml drs, it may be a question worth

asking.

Marcos.

On 6/28/07, Tracey <traceyincanada@...> wrote:

>

> Hi Marcos,

>

> Thanks for the links. I'm also very interested in this issue and

> will do some more digging in the coming days. I think this is a very

> important issue to consider seeing as we're going to be on Gleevec

> (or some other such drug) for the rest of our lives. We obviously

> wnat to be aware of anything that can interact.

>

> Garlic was mentioned in the links you provided but I wonder if this

> was referring to high dose garlic supplements or the usual clove that

> many of us would use in cooking?

>

> I'll let you know if I find anything else out that might be of

> interest as I hope everyone else will do as well.

>

> Tracey

>

>

> > > Following on the recent drug interaction thread I was wondering

> if we

> > > should also worry about other things we ingest interacting with

> our

> > > cml drug. I am looking for two kind of interactions :

> > >

> > > - First, things that interact with the drug being efficient at

> killing our bug

> > >

> > > - Second things that interact with side effects

> > >

> > > I didn't find much beside herbal products, here a link I found

> pretty

> > > exhaustive about things interacting with the CYP3A4 liver enzyme :

> > > http://www.cancerlynx.com/herbhealth.html

> > >

> > > If you would like to share sources of information I would be glad

> to

> > > have more things about usual foods (fruits, vegetables, meats, etc

> > > ...)

> > > Marcos.

> > >

> >

> >

> > --

> > Marcos Perreau Guimaraes

> > Suppes Brain Lab

> > Ventura Hall - CSLI

> > Stanford University

> > 220 Panama street

> > Stanford CA 94305-4101

> > 650 329 9920 x 305

> > 650 630 5015 (cell)

> > marcospg@...

> > montereyunderwater@...

> > www.stanford.edu/~marcospg/

> >

>

>

>

>

--

Marcos Perreau Guimaraes

Suppes Brain Lab

Ventura Hall - CSLI

Stanford University

220 Panama street

Stanford CA 94305-4101

650 329 9920 x 305

650 630 5015 (cell)

marcospg@...

montereyunderwater@...

www.stanford.edu/~marcospg/

[Guest guest]

Hi Marcos,

I've seen a few articles mention that high fat foods have been

studied with Gleevec intake and had little to no effect on plasma

concentrations.

Here's one link that says the mean absolute bioavailability was 98%

and that it was not affected by fatty food:

http://www.bccancer.bc.ca/HPI/DrugDatabase/DrugIndexPro/Imatinib.htm

And here's another link that says that the rate of absorption was

minimally reduced when taken with a high fat meal:

http://www.health.gov.il/units/pharmacy/trufot/alonim/403.pdf

Tracey

> > >

> > > That wasn't the link I ad in mind, the more complete I found

is :

> > >

> >

http://www.ingentaconnect.com/content/tandf/txen/2002/00000032/0000000

> > 6/art00001

> > > Marcos.

> > >

> >

> > > On 6/28/07, Marcos Perreau Guimaraes <montereyunderwater@>

wrote:

> > > > Following on the recent drug interaction thread I was

wondering

> > if we

> > > > should also worry about other things we ingest interacting

with

> > our

> > > > cml drug. I am looking for two kind of interactions :

> > > >

> > > > - First, things that interact with the drug being efficient at

> > killing our bug

> > > >

> > > > - Second things that interact with side effects

> > > >

> > > > I didn't find much beside herbal products, here a link I found

> > pretty

> > > > exhaustive about things interacting with the CYP3A4 liver

enzyme :

> > > > http://www.cancerlynx.com/herbhealth.html

> > > >

> > > > If you would like to share sources of information I would be

glad

> > to

> > > > have more things about usual foods (fruits, vegetables,

meats, etc

> > > > ...)

> > > > Marcos.

> > > >

> > >

> > >

> > > --

> > > Marcos Perreau Guimaraes

> > > Suppes Brain Lab

> > > Ventura Hall - CSLI

> > > Stanford University

> > > 220 Panama street

> > > Stanford CA 94305-4101

> > > 650 329 9920 x 305

> > > 650 630 5015 (cell)

> > > marcospg@

> > > montereyunderwater@

> > > www.stanford.edu/~marcospg/

> > >

> >

> >

> >

> >

>

>

>

> --

> Marcos Perreau Guimaraes

> Suppes Brain Lab

> Ventura Hall - CSLI

> Stanford University

> 220 Panama street

> Stanford CA 94305-4101

> 650 329 9920 x 305

> 650 630 5015 (cell)

> marcospg@...

> montereyunderwater@...

> www.stanford.edu/~marcospg/

>