Guest guest Posted December 30, 2007 Report Share Posted December 30, 2007 It is my understanding that you develop the mutations, sometimes as a result of your treatment. I have a trisomy 8 , or at least the last time they checked I did. I was told it was probably a result of the chemo, but sometimes my type comes and goes. Cancer sucks, and still they seem to not be real sure about the reason mutations happen. Well that is my experience. Mel -------------- Original message from vegasrnjen@...: -------------- I have a quick, yet sort of stupid question.... Do you develop the mutations or would they have already identified if one has such a thing? I guess I don't fully understand it since it hasn't come up as a concern. I am hoping that it never will....... Thanks for the explanations in advance! 35 CML 5/13/05 Syprcel 100mg Gleevec 800mg until 8/07 Wife and mother of 3 (12,8,6) **************************************See AOL's top rated recipes (http://food.aol.com/top-rated-recipes?NCID=aoltop00030000000004) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 30, 2007 Report Share Posted December 30, 2007 Hi , This isn't a stupid question at all. Some mutations are there from the beginning and others develop with time. As if that wasn't vague enough, some mutations are transient (come and go) while others are more or less permanent. Also, some mutations are more serious than others. Some mutations are known to respond to some drugs but not others so it's important to know which mutation a person has in order to treat it with the right drug. When people are diagnosed with CML, the CML cells populate most of the marrow and by doing so, they can cover up some mutations. Once a person starts treatment, a huge portion of their CML cells get killed off and this dramatically reduces the clutter. When the clutter is gone, it allows the mutations to be seen. They were always there, they were just covered up so when the clutter is lifted, they can be seen. That's the case for mutations that were always there and those typically will show up in the first year or 18 months of treatment. In the case of mutations that develop later on, many of them are not clearly understood. Some mutations tend to develop as the disease starts to accelerate so for people who have " new " mutations, it's important for them to have regular BMB's to monitor their marrow more closely. Whether or not the drugs we take actually cause some mutations to develop is a matter of debate and research. Take care, Tracey dx Jan 2002 > > I have a quick, yet sort of stupid question.... > > Do you develop the mutations or would they have already identified if one > has such a thing? I guess I don't fully understand it since it hasn't come up > as a concern. I am hoping that it never will....... > > Thanks for the explanations in advance! > > 35 > CML 5/13/05 > Syprcel 100mg > Gleevec 800mg until 8/07 > Wife and mother of 3 (12,8,6) > > > > **************************************See AOL's top rated recipes > (http://food.aol.com/top-rated-recipes?NCID=aoltop00030000000004) > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 30, 2007 Report Share Posted December 30, 2007 Hi Mel, Trisomy 8 isn't really considered a " mutation " but rather a " cytogenetic clonal evolution " . Clonal evolutions involve chromosomes. Sometime you can have an extra copy of a chromosome (as in the case of Trisomy 8), other times you may lack a copy of one chromosome (as in the case of monosomy 7) or sometimes you can have an additional translocation besides the classic 9/22 (Philadelphia chromosome). These are all examples of cytogenetic clonal evolutions. Clonal evolutions often do come and go. Their significance isn't fully understood and there have been many patients with them who had no significant problems with treatment, who went on and attained a successful CCR. Mutations on the other hand, usually refer to kinase domain mutations which are occurrences in the cell that can prevent the drugs from reaching their target and doing their job. These mutations often interfere with treatment and require attention. Take care, Tracey > > It is my understanding that you develop the mutations, sometimes as a result of your treatment. I have a trisomy 8 , or at least the last time they checked I did. I was told it was probably a result of the chemo, but sometimes my type comes and goes. Cancer sucks, and still they seem to not be real sure about the reason mutations happen. Well that is my experience. Mel > > -------------- Original message from vegasrnjen@...: -------------- > > I have a quick, yet sort of stupid question.... > > Do you develop the mutations or would they have already identified if one > has such a thing? I guess I don't fully understand it since it hasn't come up > as a concern. I am hoping that it never will....... > > Thanks for the explanations in advance! > > 35 > CML 5/13/05 > Syprcel 100mg > Gleevec 800mg until 8/07 > Wife and mother of 3 (12,8,6) > > **************************************See AOL's top rated recipes > (http://food.aol.com/top-rated-recipes?NCID=aoltop00030000000004) > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 31, 2007 Report Share Posted December 31, 2007 All of these posts about mutations have been really interesting. I was told upon dx that I Have at least 5 other " weird chromozones " . When I met with Dr. Cortes at MD I was hoping he would enlighten me with regard to these. He said he had doubted there really were 5. I never got to talk to him after my BMA just got results from my Oncologist who said " Cortes had put the weird chromozones on the shelf " whatever the hec that means???? In an e- mail from Cortes's assistant he had mentioned that they were Clonal evolutions. My God this disease is complex!!!!!!!!!! Tracey thanks for the intelligent interpretations. Donna > > > > It is my understanding that you develop the mutations, sometimes > as a result of your treatment. I have a trisomy 8 , or at least the > last time they checked I did. I was told it was probably a result of > the chemo, but sometimes my type comes and goes. Cancer sucks, and > still they seem to not be real sure about the reason mutations > happen. Well that is my experience. Mel > > > > -------------- Original message from vegasrnjen@: -------------- > > > > I have a quick, yet sort of stupid question.... > > > > Do you develop the mutations or would they have already identified > if one > > has such a thing? I guess I don't fully understand it since it > hasn't come up > > as a concern. I am hoping that it never will....... > > > > Thanks for the explanations in advance! > > > > 35 > > CML 5/13/05 > > Syprcel 100mg > > Gleevec 800mg until 8/07 > > Wife and mother of 3 (12,8,6) > > > > **************************************See AOL's top rated recipes > > (http://food.aol.com/top-rated-recipes?NCID=aoltop00030000000004) > > > > Quote Link to comment Share on other sites More sharing options...
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