Guest guest Posted November 7, 2007 Report Share Posted November 7, 2007 Why would you go to Tasigna and not Sprycel? Just wondering... Many people who have been on Gleevec and then switched to Sprycel experience less side effects--not everyone, but lots of them. My husband is one of those people... @...: no_reply@...: Wed, 7 Nov 2007 19:17:37 +0000Subject: [ ] Tasigna Hello my CML friends and caregivers,Is there anyone active on this group that is taking the newly approved, Tasigna(AMN)drug? I've been on Gleevec for almost 4 years now, and although I look great on paper,(labs, PCR's, etc.) Gleevec has really kicked my butt with side effects and things really came to a head last week.I am currently on a Dr. approved break off of Gleevec, and I feel amazing now. (been off less than a week) and want to know if anyone can give me any input as to this new drug and how you are doing? I will be either going back onto Gleevec or possibly starting Tasigna. Will know more next week at my next Dr. visit.Any all advice would be much appreciated, Lynn Dx'd 12/03PCRU _________________________________________________________________ Peek-a-boo FREE Tricks & Treats for You! http://www.reallivemoms.com?ocid=TXT_TAGHM & loc=us Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 7, 2007 Report Share Posted November 7, 2007 Hi , I have some very big problems with edema and swelling and have been having to take 80 mg's of Lasix daily, along with potassium supplements, but it doesn't really do much to alleviate my problem. I blow up like a balloon every day. I've done a low sodium diet as well, and have not seen any difference. I have also seen an kidney specialist and all is well in that dept. Also had an echo done on my heart, thinking that I maybe having some congestive heart problems.. but the heart is good too. Lots of other tests performed.. nothing. Sprycel has a lot of fluid retention problems with some patients, (Pleural Effusion) and since I'm so sensitive to the fluid issue, it seem like a no-brainer to not take this. I recently had a Gleevec serum level test done, and my levels were sky high on 400 mg's Gleevec. I was reduced down to 300 mg's with Dr. Druker's approval, and I've still been full of side effects, with a huge weight gain, swelling edema, diarrhea, vomiting, lethargy, etc. I could go on. I may either go back to a reduced dose of Gleevec or may get to start Tasigna.. Will know more as I discuss with my Dr next week. Just wanted to put my feelers out and see what's going on with Tasigna as it was just approved for US use last week. Lynn > > > Why would you go to Tasigna and not Sprycel? Just wondering... > Many people who have been on Gleevec and then switched to Sprycel experience less side effects--not everyone, but lots of them. > My husband is one of those people... > > > > > > @...: no_reply@...: Wed, 7 Nov 2007 19:17:37 +0000Subject: [ ] Tasigna > > > > > Hello my CML friends and caregivers,Is there anyone active on this group that is taking the newly approved, Tasigna(AMN)drug? I've been on Gleevec for almost 4 years now, and although I look great on paper, (labs, PCR's, etc.) Gleevec has really kicked my butt with side effects and things really came to a head last week.I am currently on a Dr. approved break off of Gleevec, and I feel amazing now. (been off less than a week) and want to know if anyone can give me any input as to this new drug and how you are doing? I will be either going back onto Gleevec or possibly starting Tasigna. Will know more next week at my next Dr. visit.Any all advice would be much appreciated, Lynn Dx'd 12/03PCRU > > > > > > > _________________________________________________________________ > Peek-a-boo FREE Tricks & Treats for You! > http://www.reallivemoms.com?ocid=TXT_TAGHM & loc=us > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 7, 2007 Report Share Posted November 7, 2007 Hi Lynn, I don't have any personal experience with Tasigna but I was told during my recent annual checkup at MDACC that they are seeing less side effects with Tasignia than with Gleevec. They seemed to prefer Tasignia to Sprycel because of the pleural effusion issue with Sprycel. I didn't see Dr. Kantarjian this year as he was out of town so all of this came from the PA--but she seemed to be pretty knowledgeable. I don't have a lot of side effects from Gleevec but I would consider cycling just for a change after over 7 years on Gleevec. I asked about that possibility and the answer was something like--we'll see-- maybe next year. But I did get this feedback on the side effects of the new drugs. Good luck to you--I hope you find a good solution to your side effects problem. It doesn't seem you have anything to lose trying Tasignia. You could always go back to Gleevec if it didn't work out. There's likely no chance that it would change your remission status (except possibly for the better). Best wishes, Dorothy dx 5/00 pcru On Nov 7, 2007, at 2:17 PM, snickersunny wrote: > Hello my CML friends and caregivers, > > Is there anyone active on this group that is taking the newly > approved, > Tasigna(AMN)drug? > > I've been on Gleevec for almost 4 years now, and although I look great > on paper,(labs, PCR's, etc.) Gleevec has really kicked my butt with > side effects and things really came to a head last week. > > I am currently on a Dr. approved break off of Gleevec, and I feel > amazing now. (been off less than a week) and want to know if anyone > can > give me any input as to this new drug and how you are doing? I will be > either going back onto Gleevec or possibly starting Tasigna. Will know > more next week at my next Dr. visit. > > Any all advice would be much appreciated, > > Lynn > Dx'd 12/03 > PCRU > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 7, 2007 Report Share Posted November 7, 2007 I would suggest really researching Tasigna before even considering it. Tasigna has been approved by the FDA BUT with a black box warning..something that should not be taken lightly...HERE is a link[1] -shalyn > Hi Lynn, > > I don't have any personal experience with Tasigna but I was told > during my recent annual checkup at MDACC that they are seeing less > side effects with Tasignia than with Gleevec. They seemed to prefer > Tasignia to Sprycel because of the pleural effusion issue with > Sprycel. I didn't see Dr. Kantarjian this year as he was out of town > so all of this came from the PA--but she seemed to be pretty > knowledgeable. > > I don't have a lot of side effects from Gleevec but I would consider > cycling just for a change after over 7 years on Gleevec. I asked > about that possibility and the answer was something like--we'll see-- > maybe next year. But I did get this feedback on the side effects of > the new drugs. > > Good luck to you--I hope you find a good solution to your side effects > problem. It doesn't seem you have anything to lose trying Tasignia. > You could always go back to Gleevec if it didn't work out. There's > likely no chance that it would change your remission status (except > possibly for the better). > > Best wishes, > Dorothy > dx 5/00 > pcru > > On Nov 7, 2007, at 2:17 PM, snickersunny wrote: > >> Hello my CML friends and caregivers, >> >> Is there anyone active on this group that is taking the newly >> approved, >> Tasigna(AMN)drug? >> >> I've been on Gleevec for almost 4 years now, and although I look great >> on paper,(labs, PCR's, etc.) Gleevec has really kicked my butt with >> side effects and things really came to a head last week. >> >> I am currently on a Dr. approved break off of Gleevec, and I feel >> amazing now. (been off less than a week) and want to know if anyone >> can >> give me any input as to this new drug and how you are doing? I will be >> either going back onto Gleevec or possibly starting Tasigna. Will know >> more next week at my next Dr. visit. >> >> Any all advice would be much appreciated, >> >> Lynn >> Dx'd 12/03 >> PCRU >> >> >> >> > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 7, 2007 Report Share Posted December 7, 2007 Skip: I am starting at 400 mg, twice daily. And like I did with Gleevec I have a very limited knowledge of the ins and outs, like most of us do now with Gleevec. My oncologist is hopeful that I will tolerate it better than Gleevec, but I laughed when I read that " taking this drug may cause sudden death " in the pharmacology report I downloaded from Novartis. However, I will try many things and see if they respond like Gleevec. Sincerely, Matt Zero Club #1078 ville, Florida Dx January of 2005 Gleevec since March of 2005 Treated at MD Father of 3 In a message dated 12/7/2007 2:35:51 P.M. Eastern Standard Time, skipd_2002@... writes: shoot I meant to say if you have a pain in your back go to your doctor right away.. As is I did not just put it down to age or lazy etc.. and of course it was tasigna to high of a dose sorry about the extra note SkipD --- _mtmaynor@..._ (mailto:mtmaynor@...) wrote: > Because of tolerance issues with Gleevec, I begin > taking > Tasigna this week. We all know that with Gleevec > there > are some certain do's and don'ts that we learned > that > are not in the literature. Does anyone have any of > those > same " do's and don'ts " for Tasigna? > > Also, if you do not mind putting what dose you are > on. > > Sincerely, > > Matt > Zero Club #1078 > ville, Florida > Dx January of 2005 > Gleevec since March of 2005 > Treated at MD > Father of 3 > > > > > ************ **** **** ************ > AOL's list of 2007's hottest > products. > (_http://money.http://money.<WBhttp://money.http://monhttp://money.<WBhttp_ (http://money.aol.com/special/hot-products-2007?NCID=aoltop00030000000001) ) > > > [Non-text portions of this message have been > removed] > > SkipD Dx'ed Dec 1978 on Myleran(busulfan) 26 yrs on Hydroxyurea for about 1 year on Gleevec for approx 1.5 years on AMN107(Nilotinib) to now __________________________________________________________ Never miss a thing. Make your home page. _http://www..http://w_ (http://www./r/hs) **************************************Check out AOL's list of 2007's hottest products. (http://money.aol.com/special/hot-products-2007?NCID=aoltop00030000000001) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 7, 2007 Report Share Posted December 7, 2007 Thank you . I think it will be a good change. I also was told by my new oncologist of two additional drugs that are trials that are showing a lot of promise. I tried to get the numbers before I left, but in the rush of the big cancer center, I did not get the numbers. I have to go each month, so I will get them next time. Hope you have a wonderful holiday season. With warmest regards, Matt Maynor mtmaynor@... 904-219-9108 This message (including any attachments) contains confidential information intended for a specific individual and purpose, and is protected by law. If you are not the intended recipient, you should delete this message, and please advise me of your receipt. Any disclosure, copying, or distribution of this message, or the taking of any action based on it, is strictly prohibited. In a message dated 12/7/2007 2:32:49 P.M. Eastern Standard Time, deh12@... writes: Hey, Matt. I can't offer you any helpful information or advice about Tasigna, but I wish you the best of luck on it. Warmest wishes, --- In _@..._ (mailto: ) , mtmaynor@... wrote: > > Because of tolerance issues with Gleevec, I begin taking > Tasigna this week. We all know that with Gleevec there > are some certain do's and don'ts that we learned that > are not in the literature. Does anyone have any of those > same " do's and don'ts " for Tasigna? > > Also, if you do not mind putting what dose you are on. > > Sincerely, > > Matt > Zero Club #1078 > ville, Florida > Dx January of 2005 > Gleevec since March of 2005 > Treated at MD > Father of 3 > > > > > ************ **** **** ************<WBR>*********<WBR> 2007's hottest > products. > (_http://money.http://money.<WBhttp://money.http:_ (http://money.aol.com/special/hot-products-2007?) NCID=aoltop00030000NCID=ao > > > [Non-text portions of this message have been removed] > **************************************Check out AOL's list of 2007's hottest products. (http://money.aol.com/special/hot-products-2007?NCID=aoltop00030000000001) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 7, 2007 Report Share Posted December 7, 2007 Hi Matt, I'm sure many of us will want to hear about your experience with Tasigna so please share as much as you feel comfortable sharing. The only thing I know about Tasigna is that you aren't supposed to take it with food. I believe they want you to avoid food 2 hours before and 2 hours after taking your pills. This of course, is very different than Gleevec which needs to be taken with a stomach full of food. The best of luck to you, Tracey > > Because of tolerance issues with Gleevec, I begin taking > Tasigna this week. We all know that with Gleevec there > are some certain do's and don'ts that we learned that > are not in the literature. Does anyone have any of those > same " do's and don'ts " for Tasigna? > > Also, if you do not mind putting what dose you are on. > > Sincerely, > > Matt > Zero Club #1078 > ville, Florida > Dx January of 2005 > Gleevec since March of 2005 > Treated at MD > Father of 3 > > > > > **************************************Check out AOL's list of 2007's hottest > products. > (http://money.aol.com/special/hot-products-2007? NCID=aoltop00030000000001) > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 7, 2007 Report Share Posted December 7, 2007 Hi I have been on nilotinib now for about a year.. in fact it is still in trial here in Canada.. the regime is no food or drink except water 2 hours before and one hour after.. I would ask how much your going or are taking. In my case 800 mg a day was way to much and it attacked my pancreas, which landed me in the hospital for a week and a week going every day to have about a gallon of water pumped into me.. Other than that after being cut back to 400 mg a day I have been great, feel good I have other issues but I am on the green side so I thank God for every day.... SkipD --- mtmaynor@... wrote: > Because of tolerance issues with Gleevec, I begin > taking > Tasigna this week. We all know that with Gleevec > there > are some certain do's and don'ts that we learned > that > are not in the literature. Does anyone have any of > those > same " do's and don'ts " for Tasigna? > > Also, if you do not mind putting what dose you are > on. > > Sincerely, > > Matt > Zero Club #1078 > ville, Florida > Dx January of 2005 > Gleevec since March of 2005 > Treated at MD > Father of 3 > > > > > **************************************Check out > AOL's list of 2007's hottest > products. > (http://money.aol.com/special/hot-products-2007?NCID=aoltop00030000000001) > > > [Non-text portions of this message have been > removed] > > SkipD Dx'ed Dec 1978 on Myleran(busulfan) 26 yrs on Hydroxyurea for about 1 year on Gleevec for approx 1.5 years on AMN107(Nilotinib) to now ________________________________________________________________________________\ ____ Looking for last minute shopping deals? Find them fast with Search. http://tools.search./newsearch/category.php?category=shopping Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 7, 2007 Report Share Posted December 7, 2007 Hey, Matt. I can't offer you any helpful information or advice about Tasigna, but I wish you the best of luck on it. Warmest wishes, > > Because of tolerance issues with Gleevec, I begin taking > Tasigna this week. We all know that with Gleevec there > are some certain do's and don'ts that we learned that > are not in the literature. Does anyone have any of those > same " do's and don'ts " for Tasigna? > > Also, if you do not mind putting what dose you are on. > > Sincerely, > > Matt > Zero Club #1078 > ville, Florida > Dx January of 2005 > Gleevec since March of 2005 > Treated at MD > Father of 3 > > > > > **************************************Check out AOL's list of 2007's hottest > products. > (http://money.aol.com/special/hot-products-2007? NCID=aoltop00030000000001) > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 7, 2007 Report Share Posted December 7, 2007 shoot I meant to say if you have a pain in your back go to your doctor right away.. As is I did not just put it down to age or lazy etc.. and of course it was tasigna to high of a dose sorry about the extra note SkipD --- mtmaynor@... wrote: > Because of tolerance issues with Gleevec, I begin > taking > Tasigna this week. We all know that with Gleevec > there > are some certain do's and don'ts that we learned > that > are not in the literature. Does anyone have any of > those > same " do's and don'ts " for Tasigna? > > Also, if you do not mind putting what dose you are > on. > > Sincerely, > > Matt > Zero Club #1078 > ville, Florida > Dx January of 2005 > Gleevec since March of 2005 > Treated at MD > Father of 3 > > > > > **************************************Check out > AOL's list of 2007's hottest > products. > (http://money.aol.com/special/hot-products-2007?NCID=aoltop00030000000001) > > > [Non-text portions of this message have been > removed] > > SkipD Dx'ed Dec 1978 on Myleran(busulfan) 26 yrs on Hydroxyurea for about 1 year on Gleevec for approx 1.5 years on AMN107(Nilotinib) to now ________________________________________________________________________________\ ____ Never miss a thing. Make your home page. http://www./r/hs Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 8, 2007 Report Share Posted December 8, 2007 Matt were you on 800 gleevec !! Re: [ ] Tasigna Skip: I am starting at 400 mg, twice daily. And like I did with Gleevec I have a very limited knowledge of the ins and outs, like most of us do now with Gleevec. My oncologist is hopeful that I will tolerate it better than Gleevec, but I laughed when I read that " taking this drug may cause sudden death " in the pharmacology report I downloaded from Novartis. However, I will try many things and see if they respond like Gleevec. Sincerely, Matt Zero Club #1078 ville, Florida Dx January of 2005 Gleevec since March of 2005 Treated at MD Father of 3 In a message dated 12/7/2007 2:35:51 P.M. Eastern Standard Time, skipd_2002 (DOT) com writes: shoot I meant to say if you have a pain in your back go to your doctor right away.. As is I did not just put it down to age or lazy etc.. and of course it was tasigna to high of a dose sorry about the extra note SkipD --- _mtmaynoraol (DOT) mtm_ (mailto:mtmaynoraol (DOT) com) wrote: > Because of tolerance issues with Gleevec, I begin > taking > Tasigna this week. We all know that with Gleevec > there > are some certain do's and don'ts that we learned > that > are not in the literature. Does anyone have any of > those > same " do's and don'ts " for Tasigna? > > Also, if you do not mind putting what dose you are > on. > > Sincerely, > > Matt > Zero Club #1078 > ville, Florida > Dx January of 2005 > Gleevec since March of 2005 > Treated at MD > Father of 3 > > > > > ************ **** **** ************ > AOL's list of 2007's hottest > products. > (_http://money. http://money.<WBhttp://money. http://monhttp: //money.<WBhttp_ (http://money. aol.com/special/ hot-products- 2007?NCID= aoltop0003000000 0001) ) > > > [Non-text portions of this message have been > removed] > > SkipD Dx'ed Dec 1978 on Myleran(busulfan) 26 yrs on Hydroxyurea for about 1 year on Gleevec for approx 1.5 years on AMN107(Nilotinib) to now ____________ _________ _________ _________ _________ _________ _ Never miss a thing. Make your home page. _http://www.. http://w_ (http://www.. com/r/hs) ************ ********* ********* ********Check out AOL's list of 2007's hottest products. (http://money. aol.com/special/ hot-products- 2007?NCID= aoltop0003000000 0001) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 8, 2007 Report Share Posted December 8, 2007 Thank you Mel. That is wonderful. Hope you are doing well. Matt **************************************Check out AOL's list of 2007's hottest products. (http://money.aol.com/special/hot-products-2007?NCID=aoltop00030000000001) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 8, 2007 Report Share Posted December 8, 2007 , I was on 400mg of gleevec currently, but was at one time on 800 mg. Matt Re: [ ] Tasigna Matt were you on 800 gleevec !! Re: [ ] Tasigna Skip: I am starting at 400 mg, twice daily. And like I did with Gleevec I have a very limited knowledge of the ins and outs, like most of us do now with Gleevec. My oncologist is hopeful that I will tolerate it better than Gleevec, but I laughed when I read that " taking this drug may cause sudden death " in the pharmacology report I downloaded from Novartis. However, I will try many things and see if they respond like Gleevec. Sincerely, Matt Zero Club #1078 ville, Florida Dx January of 2005 Gleevec since March of 2005 Treated at MD Father of 3 In a message dated 12/7/2007 2:35:51 P.M. Eastern Standard Time, skipd_2002 (DOT) com writes: shoot I meant to say if you have a pain in your back go to your doctor right away.. As is I did not just put it down to age or lazy etc.. and of course it was tasigna to high of a dose sorry about the extra note SkipD --- _mtmaynoraol (DOT) mtm_ (mailto:mtmaynoraol (DOT) com) wrote: > Because of tolerance issues with Gleevec, I begin > taking [The entire original message is not included]= Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 8, 2007 Report Share Posted December 8, 2007 Matt, I was in the Tasigna trail. I start at 800mg, 400 in am and 400 at night. Low platlets, then put on 400mg at night only. I loved it, other than the platlets, I had no side effects at all! Mel -------------- Original message from mtmaynor@...: -------------- Because of tolerance issues with Gleevec, I begin taking Tasigna this week. We all know that with Gleevec there are some certain do's and don'ts that we learned that are not in the literature. Does anyone have any of those same " do's and don'ts " for Tasigna? Also, if you do not mind putting what dose you are on. Sincerely, Matt Zero Club #1078 ville, Florida Dx January of 2005 Gleevec since March of 2005 Treated at MD Father of 3 **************************************Check out AOL's list of 2007's hottest products. (http://money.aol.com/special/hot-products-2007?NCID=aoltop00030000000001) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2008 Report Share Posted January 21, 2008 By the way, there was once a discussion regarding whether Gleevec is or is not a type of chemotherapy. There is little discussion with that fact with Tasigna, as it comes in a package that clearly states " This is a Chemotherapy Drug, Handle with Extreme Caution " . With warm regards, Matt ville, FL DX January 2005 Gleevec March 2005 Tasigna November 2008 In a message dated 1/21/2008 10:52:53 A.M. Eastern Standard Time, mtmaynor@... writes: I had great difficulty with the GI side effects of Gleevec and begin a regimen of Tasigna last November. I have found that most of the GI issues that I had with Gleevec have promptly disappeared. Tasigna is taken twice a day on an empty stomach, at least two hours after a meal or one hour. At the beginning this is kind of hard to schedule, but I take my doses at the time I get up and at approximately 5:00 in the afternoon. The standard dose is 400 mg twice a day, however some are on 200 mg twice a day. I have also heard of people taking 400 mg once a day. I did have one scare and ended up in the ER with high pancreatic enzymes and low electrolytes. I know drink at least two 8 oz. glasses of Gatorade each day and supplement with electrolyte tablets that I obtain from Hammer Gel nutrition. For those of you with significant GI issues with Gleevec, I would encourage you to consider Tasigna as I have done well on it so far. With warm regards, Matt ville, FL DX January 2005 Gleevec March 2005 Tasigna November 2008 ************************<WBR>**Start the year off right. Easy ways to st _http://body.http://body.<WBRhttp://body.<WBRhttp://body.<WBRhttp://bo_ (http://body.aol.com/fitness/winter-exercise?NCID=aolcmp00300000002489) [Non-text portions of this message have been removed] **************Start the year off right. Easy ways to stay in shape. http://body.aol.com/fitness/winter-exercise?NCID=aolcmp00300000002489 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2008 Report Share Posted January 21, 2008 Yes, I assume that the blackbox warning you are speaking of was the " may cause sudden death " item. When I asked my oncologist about it, he stated that the worry is that you develop QT Prolongation, which can lead to ventricular arrhythmias, which as I understand it can cause cardiac arrest and then that sudden death thing. This can be an issue with a number of things and the issue of electrolytes is one of those items that can cause QT Prolongation. Like Gleevec with the Liver issues, Tasigna does cause an increase in Lipase or Pancreatic Enzymes. I have not found a way around this yet, but it appears from my tests it is a slight elevation and not of concern. For the first 28 days on the medication, you do have to have an EKG, which my GP was glad to perform. All were normal and it is a very painless and quick test. The issue with taking on an empty stomach is related to absorption rates. It seems that food elevates the absorption of Tasigna and if you take with a full stomach, the medication " spikes " absorption and can cause problems. Overall, I have found it much better for my QOL. In a message dated 1/21/2008 12:47:48 P.M. Eastern Standard Time, utfin93@... writes: Thanks Matt! Great post. I was consideing Tasigna due to same GI sides of G leevec also. Was a little taken aback by the black box warning. Did your doc discuss this with you? Also, any problems getting on your insurance formulary? Tx Rick _mtmaynor@..._ (mailto:mtmaynor@...) wrote: I had great difficulty with the GI side effects of Gleevec and begin a regimen of Tasigna last November. I have found that most of the GI issues that I had with Gleevec have promptly disappeared. Tasigna is taken twice a day on an empty stomach, at least two hours after a meal or one hour. At the beginning this is kind of hard to schedule, but I take my doses at the time I get up and at approximately 5:00 in the afternoon. The standard dose is 400 mg twice a day, however some are on 200 mg twice a day. I have also heard of people taking 400 mg once a day. I did have one scare and ended up in the ER with high pancreatic enzymes and low electrolytes. I know drink at least two 8 oz. glasses of Gatorade each day and supplement with electrolyte tablets that I obtain from Hammer Gel nutrition. For those of you with significant GI issues with Gleevec, I would encourage you to consider Tasigna as I have done well on it so far. With warm regards, Matt ville, FL DX January 2005 Gleevec March 2005 Tasigna November 2008 ************************<WBR>**Start the year off right. Easy ways to st _http://body.http://body.<WBRhttp://body.<WBRhttp://body.<WBRhttp://bo_ (http://body.aol.com/fitness/winter-exercise?NCID=aolcmp00300000002489) [Non-text portions of this message have been removed] --------------------------------- Be a better friend, newshound, and know-it-all with Mobile. Try it now. [Non-text portions of this message have been removed] **************Start the year off right. Easy ways to stay in shape. http://body.aol.com/fitness/winter-exercise?NCID=aolcmp00300000002489 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2008 Report Share Posted January 21, 2008 the description for " chemotherapy " is: the use of chemical agents in the treatment or control of disease or mental disorder. i believe as a person fighting to control a disease that will kill me unless i use a drug to keep me alive is valid. for years this word has been defined as: a bag and a line of chemicals going it to ones body for a brief time. not anymore. Re: [ ] Tasigna By the way, there was once a discussion regarding whether Gleevec is or is not a type of chemotherapy. There is little discussion with that fact with Tasigna, as it comes in a package that clearly states " This is a Chemotherapy Drug, Handle with Extreme Caution " . With warm regards, Matt ville, FL DX January 2005 Gleevec March 2005 Tasigna November 2008 In a message dated 1/21/2008 10:52:53 A.M. Eastern Standard Time, mtmaynor@... writes: I had great difficulty with the GI side effects of Gleevec and begin a regimen of Tasigna last November. I have found that most of the GI issues that I had with Gleevec have promptly disappeared. Tasigna is taken twice a day on an empty stomach, at least two hours after a meal or one hour. At the beginning this is kind of hard to schedule, but I take my doses at the time I get up and at approximately 5:00 in the afternoon. The standard dose is 400 mg twice a day, however some are on 200 mg twice a day. I have also heard of people taking 400 mg once a day. I did have one scare and ended up in the ER with high pancreatic enzymes and low electrolytes. I know drink at least two 8 oz. glasses of Gatorade each day and supplement with electrolyte tablets that I obtain from Hammer Gel nutrition. For those of you with significant GI issues with Gleevec, I would encourage you to consider Tasigna as I have done well on it so far. With warm regards, Matt ville, FL DX January 2005 Gleevec March 2005 Tasigna November 2008 ************************<WBR>**Start the year off right. Easy ways to st _http://body.http://body.<WBRhttp://body.<WBRhttp://body.<WBRhttp://bo_ (http://body.aol.com/fitness/winter-exercise?NCID=aolcmp00300000002489) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2008 Report Share Posted January 21, 2008 Thanks Matt! Great post. I was consideing Tasigna due to same GI sides of Gleevec also. Was a little taken aback by the black box warning. Did your doc discuss this with you? Also, any problems getting on your insurance formulary? Tx Rick mtmaynor@... wrote: I had great difficulty with the GI side effects of Gleevec and begin a regimen of Tasigna last November. I have found that most of the GI issues that I had with Gleevec have promptly disappeared. Tasigna is taken twice a day on an empty stomach, at least two hours after a meal or one hour. At the beginning this is kind of hard to schedule, but I take my doses at the time I get up and at approximately 5:00 in the afternoon. The standard dose is 400 mg twice a day, however some are on 200 mg twice a day. I have also heard of people taking 400 mg once a day. I did have one scare and ended up in the ER with high pancreatic enzymes and low electrolytes. I know drink at least two 8 oz. glasses of Gatorade each day and supplement with electrolyte tablets that I obtain from Hammer Gel nutrition. For those of you with significant GI issues with Gleevec, I would encourage you to consider Tasigna as I have done well on it so far. With warm regards, Matt ville, FL DX January 2005 Gleevec March 2005 Tasigna November 2008 **************Start the year off right. Easy ways to stay in shape. http://body.aol.com/fitness/winter-exercise?NCID=aolcmp00300000002489 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2008 Report Share Posted March 23, 2008 Terry, Sorry you are having a rough time and hope that it will pass. My experience with Tasigna is limited to a couple of months but it seems to me that there was some fatigue and body aches for the first few weeks that later abated mostly. If you are feeling fatigued, see if you can get your hormone levels checked. TKI's have a way of messing with them and that can make a major difference. BTW, I'm a big Bernie Siegel fan also. I've got a number of his books and they got me thru sometimes when nothing else would. Also, Dr. Larry LeShan's book, " Cancer as a Turning Point " is another classic. Best Rick Barb Stanley <barbarastanley@...> wrote: Terry Hang in there. It does get better. I tanked too, for a short time at first, but I will say that it just all takes time.I am glad you are counseling because that can do wonders... loved it myself. One of the best things that helped me at the time was the Seigal book " Love, Medicine and Miracles. " Bernie Seigal gives you things you can do to control what you can. It made me feel more like partner in my healing ( I am a big control freak) and so I felt in charge somewhat. I would recomend it. Be well, and take really good care of yourself. Barb > > Hello All, > I am on tasigna, although here in Canada it is a trial > drug called AMN107. > I started it in May '07 and it god my counts going > down which the Gleevec stopped doing. All well and > good...but I developed psoriasis and then a deep, dark > depression. I spent days and weeks in bed. I could > scarcely talk to my family and wouldn't talk on the > phone at all. > I finally asked me Dr. what length of time I could > expect to live if I dropped all the drugs. She took > this to mean I was suicidal, but that was not it at > all, I wasn't thinking of killing myself, just letting > nature take it's course. > She got me some counseling and I can now see the end > of the tunnel. I'm not where I want to be but over the > past 4- weeks, life has become more worthwhile. > I told all the Dr's I saw that I was not interested in > quantity of life without quality of life, that is > still my outlook, but I am getting back some quality. > Happy Easter to all. > Terry > > > > Yuwie is like any other social networking site, EXCEPT! > Use Yuwie - Get Paid! Yuwie is 100% FREE! > http://www.yuwie.com/yuwie.asp?r=561003 & vid= > > > > > > > > __________________________________________________________ > Looking for the perfect gift? Give the gift of Flickr! > > http://www.flickr.com/gift/ > --------------------------------- Be a better friend, newshound, and know-it-all with Mobile. Try it now. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2008 Report Share Posted March 23, 2008 Hi Terry, Gosh that is awful for you to experience. Is this a known side effect of Tasigna? And the psoriasis, do you still have that? That must have been terrible to go through. I hope you are getting on top of it all now. Regards, from Downunder " Are you a half full or half empty glass of water? " _____ From: [mailto: ] On Behalf Of Terry & Whelan Sent: Sunday, 23 March 2008 9:18 AM Subject: [ ] tasigna Hello All, I am on tasigna, although here in Canada it is a trial drug called AMN107. I started it in May '07 and it god my counts going down which the Gleevec stopped doing. All well and good...but I developed psoriasis and then a deep, dark depression. I spent days and weeks in bed. I could scarcely talk to my family and wouldn't talk on the phone at all. I finally asked me Dr. what length of time I could expect to live if I dropped all the drugs. She took this to mean I was suicidal, but that was not it at all, I wasn't thinking of killing myself, just letting nature take it's course. She got me some counseling and I can now see the end of the tunnel. I'm not where I want to be but over the past 4- weeks, life has become more worthwhile. I told all the Dr's I saw that I was not interested in quantity of life without quality of life, that is still my outlook, but I am getting back some quality. Happy Easter to all. Terry Yuwie is like any other social networking site, EXCEPT! Use Yuwie - Get Paid! Yuwie is 100% FREE! http://www.yuwie. <http://www.yuwie.com/yuwie.asp?r=561003 & vid=> com/yuwie.asp?r=561003 & vid= __________________________________________________________ Looking for the perfect gift? Give the gift of Flickr! http://www.flickr. <http://www.flickr.com/gift/> com/gift/ Quote Link to comment Share on other sites More sharing options...
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