Re: Gleevec/Sprycel Side Effects

[Guest guest]

Yes, I too have had dental problems while on Gleevec. I

have been on it for almost 36 months and I have had to

have two caps on my back teeth and I think I will need

a third at my next check up. Before you said that, I did

not think it was related to Gleevec, but now that you bring

it up, it could be related.

Matt

Diagnosed January 2005

In a message dated 12/4/2007 5:52:00 P.M. Eastern Standard Time,

lblaine767@... writes:

Can anyone tell me if you have had any side effects with either

Gleevec or Sprycel that causes you dental problems? I have had to

have two fillings in two different teeth where it seems as though my

teeth are crumbling...teeth are crumbling...<WBR>never had a probl

is really strange. My dentist said this was not caused from grinding

or clenching my teeth so I just thought I would throw it out there and

see if anyone else has heard of or experienced this side effect????

Thanks!

**************************************Check out AOL's list of 2007's hottest

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[Guest guest]

Hi,

This issue has been brought up over the years. There hasn't been

anything conclusively determined though that would show Gleevec as the

cause of dental problems.

The first thing I usually notice when this subject is raised, is that

it's from people who are over 50. You don't mention your age but age

does play a role in dental health.

For myself, I've been on Gleevec just short of 6 years and I've had

absolutely no dental issues at all. I haven't even had a filling in

all those years. I also don't floss and only go for cleaning once a

year so if anyone should be a candidate for dental problems, I'd say it

would be me The other thing I should mention is that I'm only 37 so

I'm sure that has as much to do with it as anything else.

My mother on the other hand, is perfectly healthy and yet has had no

end of grief with her teeth to the point where she actually had all the

top ones removed. Her problems started when she was in her 50's but

yet she's been healthy her whole life and never had dental issues

before that.

So while I suppose it's possible that Gleevec (and Sprycel) could cause

dental problems, I personally tend to think that age is more of a

factor.

Take care,

Tracey

>

> Can anyone tell me if you have had any side effects with either

> Gleevec or Sprycel that causes you dental problems? I have had to

> have two fillings in two different teeth where it seems as though my

> teeth are crumbling...never had a problem with my teeth before so this

> is really strange. My dentist said this was not caused from grinding

> or clenching my teeth so I just thought I would throw it out there and

> see if anyone else has heard of or experienced this side effect????

>

> Thanks!

>

[Guest guest]

Neutropenia may cause dental problems. Also changes of diet that were

coincidental with cml dx, lack of calcium, aciditic fruits.

Though like Tracey I have no special teeth problems since I am on

gleevec (2 1/2 years). I am 41.

Marcos.

On Dec 4, 2007 3:05 PM, Tracey <traceyincanada@...> wrote:

>

>

>

>

> Hi,

>

> This issue has been brought up over the years. There hasn't been

> anything conclusively determined though that would show Gleevec as the

> cause of dental problems.

>

> The first thing I usually notice when this subject is raised, is that

> it's from people who are over 50. You don't mention your age but age

> does play a role in dental health.

>

> For myself, I've been on Gleevec just short of 6 years and I've had

> absolutely no dental issues at all. I haven't even had a filling in

> all those years. I also don't floss and only go for cleaning once a

> year so if anyone should be a candidate for dental problems, I'd say it

> would be me The other thing I should mention is that I'm only 37 so

> I'm sure that has as much to do with it as anything else.

>

> My mother on the other hand, is perfectly healthy and yet has had no

> end of grief with her teeth to the point where she actually had all the

> top ones removed. Her problems started when she was in her 50's but

> yet she's been healthy her whole life and never had dental issues

> before that.

>

> So while I suppose it's possible that Gleevec (and Sprycel) could cause

> dental problems, I personally tend to think that age is more of a

> factor.

>

> Take care,

> Tracey

>

>

>

> >

> > Can anyone tell me if you have had any side effects with either

> > Gleevec or Sprycel that causes you dental problems? I have had to

> > have two fillings in two different teeth where it seems as though my

> > teeth are crumbling...never had a problem with my teeth before so this

> > is really strange. My dentist said this was not caused from grinding

> > or clenching my teeth so I just thought I would throw it out there and

> > see if anyone else has heard of or experienced this side effect????

> >

> > Thanks!

> >

>

>

>

>

--

Marcos Perreau Guimaraes

Suppes Brain Lab

Ventura Hall - CSLI

Stanford University

220 Panama street

Stanford CA 94305-4101

650 614 2305

650 630 5015 (cell)

marcospg@...

montereyunderwater@...

www.stanford.edu/~marcospg/

[Guest guest]

I think that sprycel depletes you of calcium. My teeth too hurt and have started

having trouble with them and my bones.

[ ] Gleevec/Sprycel Side Effects

Can anyone tell me if you have had any side effects with either

Gleevec or Sprycel that causes you dental problems? I have had to

have two fillings in two different teeth where it seems as though my

teeth are crumbling... never had a problem with my teeth before so this

is really strange. My dentist said this was not caused from grinding

or clenching my teeth so I just thought I would throw it out there and

see if anyone else has heard of or experienced this side effect????

Thanks!

________________________________________________________________________________\

____

Be a better sports nut! Let your teams follow you

with Mobile. Try it now.

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[Guest guest]

Hi,

I'm very happy to report I haee not had any side effects at all from Sprycel and

am in a non-detectable state.

L

[ ] Gleevec/Sprycel Side Effects

Can anyone tell me if you have had any side effects with either

Gleevec or Sprycel that causes you dental problems? I have had to

have two fillings in two different teeth where it seems as though my

teeth are crumbling... never had a problem with my teeth before so this

is really strange. My dentist said this was not caused from grinding

or clenching my teeth so I just thought I would throw it out there and

see if anyone else has heard of or experienced this side effect????

Thanks!

__________________________________________________________

Be a better sports nut! Let your teams follow you

with Mobile. Try it now.

http://mobile./sports;_ylt=At9_qDKvtAbMuh1G1SQtBI7ntAcJ

[Guest guest]

Hi,

I'm glad you asked because I was wondering it also.

I am over 50 -smile- but my very expensive dental work

is breaking down- my crowns on my bridges are falling

apart. My dentist suggested taht perhaps the stress

from being newly diagnosed was causing me to grind my

teeth at night putting extra stress on bridgework

because it just suddenly started happening. No

problems with my own teeth but the artifical caps keep

breaking. Different dentists so I know it is not the

integrity of the work unless they both used the same

lab.

On another note- I wrote to Dr. Druker about another

question I had. Gleevec is wonderful but clearly it

is a powerful form of chemo. I was soooo sick when I

statrted taking gleevec and had so many side effects

that I was wondering if it was possible to overtime

poison our partners by exposing them to .....hmmm how

do I say this... fluids during itimacy. He said no

one ever asked him the question before but that while

there was no data he thought that the amount excreted

in fluids would be so small that there would not be

any harm to anyone else.

He is a very nice man and he responded very quickly to

my email.

Chi

--- lblaine767 <lblaine767@...> wrote:

> Can anyone tell me if you have had any side effects

> with either

> Gleevec or Sprycel that causes you dental problems?

> I have had to

> have two fillings in two different teeth where it

> seems as though my

> teeth are crumbling...never had a problem with my

> teeth before so this

> is really strange. My dentist said this was not

> caused from grinding

> or clenching my teeth so I just thought I would

> throw it out there and

> see if anyone else has heard of or experienced this

> side effect????

>

> Thanks!

>

>

________________________________________________________________________________\

____

Never miss a thing. Make your home page.

http://www./r/hs

[Guest guest]

I am so glad to hear from all of you with your own experiences! I am 46

and was on Gleevec for 1 1/2 years and went into complete remission :-)

Both the BCR-ABL and Bone Marrow Biopsy were clear of CML...Just when I

felt life was good and I was winning, the next BCR-ABL came back

elevated on the high end and received a call from the doctor. He

immediately put me on Sprycel and have been taking it for a little over

3 weeks now. I'm having lots of side effects (headaches, vision

problems, weight gain, thinking problems) and so on. Thank God for

these support groups! I thought I was going crazy having all these

weird side effects, but now have found a great source of CMLers to chat

with and find out these things are not just happening to me!!! Wow,

what a relief! Thanks for all the great feedback on the dental

question. Maybe it won't be so bad now that I'm on Sprycel! :-)

Lblaine767

>

> > Can anyone tell me if you have had any side effects

> > with either

> > Gleevec or Sprycel that causes you dental problems?

> > I have had to

> > have two fillings in two different teeth where it

> > seems as though my

> > teeth are crumbling...never had a problem with my

> > teeth before so this

> > is really strange. My dentist said this was not

> > caused from grinding

> > or clenching my teeth so I just thought I would

> > throw it out there and

> > see if anyone else has heard of or experienced this

> > side effect????

> >

> > Thanks!

> >

> >

>

>

>

>

________________________________________________________________________\

____________

> Never miss a thing. Make your home page.

> http://www./r/hs

>

[Guest guest]

Do you have Dr Drukers e-mail address? I had it over 7 years ago when I was

dx'd but I can't find it now.

If not does any one else on the group have it and can you e-mail it to me

please.

Thanks

ez

[Guest guest]

,

No I don't have " Dr. Drukers " email...who is this person???

Lenda

>

> Do you have Dr Drukers e-mail address? I had it over 7 years ago when

I was

> dx'd but I can't find it now.

>

> If not does any one else on the group have it and can you e-mail it to

me

> please.

>

> Thanks

>

> ez

>

>

>

>

>

>

[Guest guest]

Dr. Druker is the man behind " The Gold " !!! He is the doctor who is responsible

for the development of Gleevec!!!! An amazing man whose life goal is to CURE

CML.

@...: lblaine767@...: Thu, 6 Dec 2007 22:59:26

+0000Subject: [ ] Re: Gleevec/Sprycel Side Effects

,No I don't have " Dr. Drukers " email...who is this person???Lenda>> Do you have Dr

Drukers e-mail address? I had it over 7 years ago whenI was> dx'd but I can't

find it now.>> If not does any one else on the group have it and can you e-mail

it tome> please.>> Thanks>> ez>>>>>> [Non-text portions of this

message have been removed]>

_________________________________________________________________

Connect and share in new ways with Windows Live.

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[Guest guest]

put his name in your search engine – that’s how I found his email address.

Barbara Hundley

<http://www.my-personal-assist.com> www.my-personal-assist.com

_____

From: [mailto: ] On Behalf Of

lblaine767

Sent: Thursday, December 06, 2007 5:59 PM

Subject: [ ] Re: Gleevec/Sprycel Side Effects

,

No I don't have " Dr. Drukers " email...who is this person???

Lenda

>

> Do you have Dr Drukers e-mail address? I had it over 7 years ago when

I was

> dx'd but I can't find it now.

>

> If not does any one else on the group have it and can you e-mail it to

me

> please.

>

> Thanks

>

> ez

>

>

>

>

>

>

[Guest guest]

Dr. Druker drukerb@... 503-494-5596

Zavie (age 69)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.2 log reduction Jun/07

3.6 log reduction Sep/07

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 309-296-0807

Cell: 613-202-0204

ID: zaviem

_____

From: [mailto: ] On Behalf Of

ez

Sent: December 6, 2007 11:18 AM

Subject: [ ] Re: Gleevec/Sprycel Side Effects

Do you have Dr Drukers e-mail address? I had it over 7 years ago when I was

dx'd but I can't find it now.

If not does any one else on the group have it and can you e-mail it to me

please.

Thanks

ez

[Guest guest]

Just out of cursity Say Gleevec 400 cost $110.00 per pill what does Sprycel cost

and is it a pill!!

[ ] Re: Gleevec/Sprycel Side Effects

Do you have Dr Drukers e-mail address? I had it over 7 years ago when I was

dx'd but I can't find it now.

If not does any one else on the group have it and can you e-mail it to me

please.

Thanks

ez

[Guest guest]

If my math is correct, it looks like it runs $182.57 per pill. The original

price on my prescription was $5477. Lord, if I had to pay that each month I

don't think I would live very long! Thank goodness we have good insurance!!!!!

Shipley <paulorkay@...> wrote: Just out

of cursity Say Gleevec 400 cost $110.00 per pill what does Sprycel cost and is

it a pill!!

[ ] Re: Gleevec/Sprycel Side Effects

Do you have Dr Drukers e-mail address? I had it over 7 years ago when I was

dx'd but I can't find it now.

If not does any one else on the group have it and can you e-mail it to me

please.

Thanks

ez