Re: Gleevec Side Effects diminishing

[Guest guest]

>

> Hi All,

>

> I just had a quick question for all the experts here. My husband

has

> been on Gleevec 800 mgs for about 6 months. For one year prior to

that

> he was on 400mg. All during that time he has had diahhrea at least

> once or twice a day. All of a sudden, that has stopped. Do you

think

> that means his response to the medicine will lessen? His PCR test

in

> December went from .001 to .007 but he had his blood drawn while he

was

> recovering from a nasty flu so we are going to have that redone

next

> week. Of course, your mind starts to wander. Anyway, just

wondering

> if anyone else has had their side effects go away.

>

> Thank for your help

> Debbie

> Husband Dx 7/06

> CCR 10/06

> MMR 7/07 PCR .002

> 10/07 PCR .001

> 12/07 PCR .007

Debbie

I am pretty sure there is no correlation between side effects and

anti-leukemia activity. I think its more likely that his body is

adjusting to the drug.

Those " fluctuations " are within the normal variation for the PCR

test. It depends on the lab but the only cause for some concern

would be if it continued going up over a few more tests and went well

over 0.05 %

[Guest guest]

Yes! Thank God, yes! The good thing about the early weeks on Gleevec is having

everyone reassure you that this, too, shall pass, and by gum, for the most part,

it does.

@...: no_reply@...: Wed, 16 Jan 2008

20:46:55 +0000Subject: [ ] Gleevec Side Effects diminishing

Hi All,I just had a quick question for all the experts here. My husband has been

on Gleevec 800 mgs for about 6 months. For one year prior to that he was on

400mg. All during that time he has had diahhrea at least once or twice a day.

All of a sudden, that has stopped. Do you think that means his response to the

medicine will lessen? His PCR test in December went from .001 to .007 but he had

his blood drawn while he was recovering from a nasty flu so we are going to have

that redone next week. Of course, your mind starts to wander. Anyway, just

wondering if anyone else has had their side effects go away.Thank for your

helpDebbieHusband Dx 7/06CCR 10/06MMR 7/07 PCR .00210/07 PCR .00112/07 PCR .007

_________________________________________________________________

Get the power of Windows + Web with the new Windows Live.

http://www.windowslive.com?ocid=TXT_TAGHM_Wave2_powerofwindows_012008

[Guest guest]

-

Thanks for the words of encouragement. It is unbelievable how much

easier it is to deal with things when you receive a few kind words of

support.

We retest next week. Keep a good thought everyone! I will keep you

posted with the results.

Deb

-- In , " " <timothyfarley16@...> wrote:

>

>

> >

> > Hi All,

> >

> > I just had a quick question for all the experts here. My husband

> has

> > been on Gleevec 800 mgs for about 6 months. For one year prior

to

> that

> > he was on 400mg. All during that time he has had diahhrea at

least

> > once or twice a day. All of a sudden, that has stopped. Do you

> think

> > that means his response to the medicine will lessen? His PCR

test

> in

> > December went from .001 to .007 but he had his blood drawn while

he

> was

> > recovering from a nasty flu so we are going to have that redone

> next

> > week. Of course, your mind starts to wander. Anyway, just

> wondering

> > if anyone else has had their side effects go away.

> >

> > Thank for your help

> > Debbie

> > Husband Dx 7/06

> > CCR 10/06

> > MMR 7/07 PCR .002

> > 10/07 PCR .001

> > 12/07 PCR .007

>

>

> Debbie

>

> I am pretty sure there is no correlation between side effects and

> anti-leukemia activity. I think its more likely that his body is

> adjusting to the drug.

>

> Those " fluctuations " are within the normal variation for the PCR

> test. It depends on the lab but the only cause for some concern

> would be if it continued going up over a few more tests and went

well

> over 0.05 %

>

[Guest guest]

Hi Debbie,

Could you please write me at e-mail: zmiller@....

Your husband has had an outstanding response to Gleevec (#1101 in the Zero

Club). Achieving MMR within 1 year guarantees that he will not relapse.

Zavie

Zavie (age 69)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.2 log reduction Jun/07

3.6 log reduction Sep/07

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 309-296-0807

Cell: 613-202-0204

ID: zaviem

_____

From: [mailto: ] On Behalf Of rdfalc

Sent: January 16, 2008 7:10 PM

Subject: [ ] Re: Gleevec Side Effects diminishing

-

Thanks for the words of encouragement. It is unbelievable how much

easier it is to deal with things when you receive a few kind words of

support.

We retest next week. Keep a good thought everyone! I will keep you

posted with the results.

Deb

-- In groups (DOT) <mailto:%40> com, " "

<timothyfarley16@...> wrote:

>

>

> >

> > Hi All,

> >

> > I just had a quick question for all the experts here. My husband

> has

> > been on Gleevec 800 mgs for about 6 months. For one year prior

to

> that

> > he was on 400mg. All during that time he has had diahhrea at

least

> > once or twice a day. All of a sudden, that has stopped. Do you

> think

> > that means his response to the medicine will lessen? His PCR

test

> in

> > December went from .001 to .007 but he had his blood drawn while

he

> was

> > recovering from a nasty flu so we are going to have that redone

> next

> > week. Of course, your mind starts to wander. Anyway, just

> wondering

> > if anyone else has had their side effects go away.

> >

> > Thank for your help

> > Debbie

> > Husband Dx 7/06

> > CCR 10/06

> > MMR 7/07 PCR .002

> > 10/07 PCR .001

> > 12/07 PCR .007

>

>

> Debbie

>

> I am pretty sure there is no correlation between side effects and

> anti-leukemia activity. I think its more likely that his body is

> adjusting to the drug.

>

> Those " fluctuations " are within the normal variation for the PCR

> test. It depends on the lab but the only cause for some concern

> would be if it continued going up over a few more tests and went

well

> over 0.05 %

>

[Guest guest]

Hi Debbie,

I remember thinking the same thing years ago when I suddenly had a

normal bowel movement for the first time in many months....lol. I've

since realized that side effects come and go without any logic or

predictability.

I can go months without any diarreah then I'll have a few days with

it. I guess food has some sort of role to play but the other side

effects also seem to wax and wane.

Some days I wake up looking like I've been punched in the eyes and

other days I look semi-normal. Some days I drag my behind around all

day because I'm so tired and other days I'm full of energy. Some

days I can concentrate on what I'm doing and other days I feel like I

have Alzheimer's.

I guess there are lots of variables to consider such as diet, sleep,

emotional issues going on etc but the bottom line is that things do

come and go and thankfully, it has nothing to do with how well the

medicine is working.

PCR tests have a certain amount of variability and 0.001 to 0.007 is

within the normal variations for most labs so please don't worry

about that. That's why they say to watch the trend of PCR tests

rather than reaching any conclusions from just one test.

Take care,

Tracey

dx 6 years ago today

>

> Hi All,

>

> I just had a quick question for all the experts here. My husband

has

> been on Gleevec 800 mgs for about 6 months. For one year prior to

that

> he was on 400mg. All during that time he has had diahhrea at least

> once or twice a day. All of a sudden, that has stopped. Do you

think

> that means his response to the medicine will lessen? His PCR test

in

> December went from .001 to .007 but he had his blood drawn while he

was

> recovering from a nasty flu so we are going to have that redone

next

> week. Of course, your mind starts to wander. Anyway, just

wondering

> if anyone else has had their side effects go away.

>

> Thank for your help

> Debbie

> Husband Dx 7/06

> CCR 10/06

> MMR 7/07 PCR .002

> 10/07 PCR .001

> 12/07 PCR .007

>

[Guest guest]

,

Six years! That is wonderful, especially since you are healthy and

and inspiration to everyone here.

I love your message. You hit the nail on the head. For my husband

to tell me that he is upset he hasn't had a " Gleevec Bowel Movement "

is really almost funny. Who would have thought you'd miss that!!

But of course, you kind of lose your innocence after the initial

diagnosis and never again feel like you can take anything for

granted. A dear friend of ours who is a breast cancer survivor, 6

years now, said that my husband needs to get used to being someone

with cancer. That it is a " condition " that we have to learn to live

with. And that is what we are doing. Like diabetes we watch it

every day, watch our diet and when we get scared, we lean on you guys

and you help us through every time.

Now the weight gain......sadly that is still there. And I am a very

sympathetic spouse who has gained right along with him.

Many thanks Tracey for your words of encouragment.

Debbie

> >

> > Hi All,

> >

> > I just had a quick question for all the experts here. My husband

> has

> > been on Gleevec 800 mgs for about 6 months. For one year prior

to

> that

> > he was on 400mg. All during that time he has had diahhrea at

least

> > once or twice a day. All of a sudden, that has stopped. Do you

> think

> > that means his response to the medicine will lessen? His PCR

test

> in

> > December went from .001 to .007 but he had his blood drawn while

he

> was

> > recovering from a nasty flu so we are going to have that redone

> next

> > week. Of course, your mind starts to wander. Anyway, just

> wondering

> > if anyone else has had their side effects go away.

> >

> > Thank for your help

> > Debbie

> > Husband Dx 7/06

> > CCR 10/06

> > MMR 7/07 PCR .002

> > 10/07 PCR .001

> > 12/07 PCR .007

> >

>

[Guest guest]

I was wondering if you all get fevers, like your under a sun lamp, but don't

sweat?

rdfalc <no_reply > wrote:

,

Six years! That is wonderful, especially since you are healthy and

and inspiration to everyone here.

I love your message. You hit the nail on the head. For my husband

to tell me that he is upset he hasn't had a " Gleevec Bowel Movement "

is really almost funny. Who would have thought you'd miss that!!

But of course, you kind of lose your innocence after the initial

diagnosis and never again feel like you can take anything for

granted. A dear friend of ours who is a breast cancer survivor, 6

years now, said that my husband needs to get used to being someone

with cancer. That it is a " condition " that we have to learn to live

with. And that is what we are doing. Like diabetes we watch it

every day, watch our diet and when we get scared, we lean on you guys

and you help us through every time.

Now the weight gain......sadly that is still there. And I am a very

sympathetic spouse who has gained right along with him.

Many thanks Tracey for your words of encouragment.

Debbie

> >

> > Hi All,

> >

> > I just had a quick question for all the experts here. My husband

> has

> > been on Gleevec 800 mgs for about 6 months. For one year prior

to

> that

> > he was on 400mg. All during that time he has had diahhrea at

least

> > once or twice a day. All of a sudden, that has stopped. Do you

> think

> > that means his response to the medicine will lessen? His PCR

test

> in

> > December went from .001 to .007 but he had his blood drawn while

he

> was

> > recovering from a nasty flu so we are going to have that redone

> next

> > week. Of course, your mind starts to wander. Anyway, just

> wondering

> > if anyone else has had their side effects go away.

> >

> > Thank for your help

> > Debbie

> > Husband Dx 7/06

> > CCR 10/06

> > MMR 7/07 PCR .002

> > 10/07 PCR .001

> > 12/07 PCR .007

> >

>

---------------------------------

Looking for last minute shopping deals? Find them fast with Search.

[Guest guest]

Hi ,

Do you mean a hot flash or just your face flushing? I get both.

Sometimes my face is tomato red but I think it's more rosacea than

Gleevec. Do you actually have a fever or just feel like you do?

Some people do go through a period where they have frequent fevers

when they first start Gleevec.

Tracey

> > >

> > > Hi All,

> > >

> > > I just had a quick question for all the experts here. My

husband

> > has

> > > been on Gleevec 800 mgs for about 6 months. For one year prior

> to

> > that

> > > he was on 400mg. All during that time he has had diahhrea at

> least

> > > once or twice a day. All of a sudden, that has stopped. Do you

> > think

> > > that means his response to the medicine will lessen? His PCR

> test

> > in

> > > December went from .001 to .007 but he had his blood drawn

while

> he

> > was

> > > recovering from a nasty flu so we are going to have that redone

> > next

> > > week. Of course, your mind starts to wander. Anyway, just

> > wondering

> > > if anyone else has had their side effects go away.

> > >

> > > Thank for your help

> > > Debbie

> > > Husband Dx 7/06

> > > CCR 10/06

> > > MMR 7/07 PCR .002

> > > 10/07 PCR .001

> > > 12/07 PCR .007

> > >

> >

>

>

>

>

>

>

> ---------------------------------

> Looking for last minute shopping deals? Find them fast with

Search.

>

>

[Guest guest]

It's a fever, because I use too ha hot flashes. Can CML cause vision problems?

Tracey <traceyincanada@...> wrote: Hi ,

Do you mean a hot flash or just your face flushing? I get both.

Sometimes my face is tomato red but I think it's more rosacea than

Gleevec. Do you actually have a fever or just feel like you do?

Some people do go through a period where they have frequent fevers

when they first start Gleevec.

Tracey

> > >

> > > Hi All,

> > >

> > > I just had a quick question for all the experts here. My

husband

> > has

> > > been on Gleevec 800 mgs for about 6 months. For one year prior

> to

> > that

> > > he was on 400mg. All during that time he has had diahhrea at

> least

> > > once or twice a day. All of a sudden, that has stopped. Do you

> > think

> > > that means his response to the medicine will lessen? His PCR

> test

> > in

> > > December went from .001 to .007 but he had his blood drawn

while

> he

> > was

> > > recovering from a nasty flu so we are going to have that redone

> > next

> > > week. Of course, your mind starts to wander. Anyway, just

> > wondering

> > > if anyone else has had their side effects go away.

> > >

> > > Thank for your help

> > > Debbie

> > > Husband Dx 7/06

> > > CCR 10/06

> > > MMR 7/07 PCR .002

> > > 10/07 PCR .001

> > > 12/07 PCR .007

> > >

> >

>

>

>

>

>

>

> ---------------------------------

> Looking for last minute shopping deals? Find them fast with

Search.

>

>

[Guest guest]

Yes CML can cause vision problems. In fact, that's how some people

get diagnosed.

Tracey

-- In , Fiol <rachel_art_design@...> wrote:

>

> It's a fever, because I use too ha hot flashes. Can CML cause

vision problems?

>

> Tracey <traceyincanada@...> wrote: Hi ,

>

> Do you mean a hot flash or just your face flushing? I get both.

> Sometimes my face is tomato red but I think it's more rosacea than

> Gleevec. Do you actually have a fever or just feel like you do?

> Some people do go through a period where they have frequent fevers

> when they first start Gleevec.

>

> Tracey

>

>

> > > >

> > > > Hi All,

> > > >

> > > > I just had a quick question for all the experts here. My

> husband

> > > has

> > > > been on Gleevec 800 mgs for about 6 months. For one year

prior

> > to

> > > that

> > > > he was on 400mg. All during that time he has had diahhrea at

> > least

> > > > once or twice a day. All of a sudden, that has stopped. Do

you

> > > think

> > > > that means his response to the medicine will lessen? His PCR

> > test

> > > in

> > > > December went from .001 to .007 but he had his blood drawn

> while

> > he

> > > was

> > > > recovering from a nasty flu so we are going to have that

redone

> > > next

> > > > week. Of course, your mind starts to wander. Anyway, just

> > > wondering

> > > > if anyone else has had their side effects go away.

> > > >

> > > > Thank for your help

> > > > Debbie

> > > > Husband Dx 7/06

> > > > CCR 10/06

> > > > MMR 7/07 PCR .002

> > > > 10/07 PCR .001

> > > > 12/07 PCR .007

> > > >

> > >

> >

> >

> >

> >

> >

> >

> > ---------------------------------

> > Looking for last minute shopping deals? Find them fast with

> Search.

> >

> >

[Guest guest]

Thank you sooo much...I thought I was going blind!! The light really bothers

me...as if I looked into a bright light I get those circles kina things...

Tracey <traceyincanada@...> wrote:

Yes CML can cause vision problems. In fact, that's how some people

get diagnosed.

Tracey

-- In , Fiol <rachel_art_design@...> wrote:

>

> It's a fever, because I use too ha hot flashes. Can CML cause

vision problems?

>

> Tracey <traceyincanada@...> wrote: Hi ,

>

> Do you mean a hot flash or just your face flushing? I get both.

> Sometimes my face is tomato red but I think it's more rosacea than

> Gleevec. Do you actually have a fever or just feel like you do?

> Some people do go through a period where they have frequent fevers

> when they first start Gleevec.

>

> Tracey

>

>

> > > >

> > > > Hi All,

> > > >

> > > > I just had a quick question for all the experts here. My

> husband

> > > has

> > > > been on Gleevec 800 mgs for about 6 months. For one year

prior

> > to

> > > that

> > > > he was on 400mg. All during that time he has had diahhrea at

> > least

> > > > once or twice a day. All of a sudden, that has stopped. Do

you

> > > think

> > > > that means his response to the medicine will lessen? His PCR

> > test

> > > in

> > > > December went from .001 to .007 but he had his blood drawn

> while

> > he

> > > was

> > > > recovering from a nasty flu so we are going to have that

redone

> > > next

> > > > week. Of course, your mind starts to wander. Anyway, just

> > > wondering

> > > > if anyone else has had their side effects go away.

> > > >

> > > > Thank for your help

> > > > Debbie

> > > > Husband Dx 7/06

> > > > CCR 10/06

> > > > MMR 7/07 PCR .002

> > > > 10/07 PCR .001

> > > > 12/07 PCR .007

> > > >

> > >

> >

> >

> >

> >

> >

> >

> > ---------------------------------

> > Looking for last minute shopping deals? Find them fast with

> Search.

> >

> >

[Guest guest]

Hi ,

You should have your eyes checked out. CML is just one of a variety

of reasons you could be having vision problems. Sometimes treatment

is necessary and the earlier you start, the better.

Tracey

> > > > >

> > > > > Hi All,

> > > > >

> > > > > I just had a quick question for all the experts here. My

> > husband

> > > > has

> > > > > been on Gleevec 800 mgs for about 6 months. For one year

> prior

> > > to

> > > > that

> > > > > he was on 400mg. All during that time he has had diahhrea

at

> > > least

> > > > > once or twice a day. All of a sudden, that has stopped. Do

> you

> > > > think

> > > > > that means his response to the medicine will lessen? His

PCR

> > > test

> > > > in

> > > > > December went from .001 to .007 but he had his blood drawn

> > while

> > > he

> > > > was

> > > > > recovering from a nasty flu so we are going to have that

> redone

> > > > next

> > > > > week. Of course, your mind starts to wander. Anyway, just

> > > > wondering

> > > > > if anyone else has had their side effects go away.

> > > > >

> > > > > Thank for your help

> > > > > Debbie

> > > > > Husband Dx 7/06

> > > > > CCR 10/06

> > > > > MMR 7/07 PCR .002

> > > > > 10/07 PCR .001

> > > > > 12/07 PCR .007

> > > > >

> > > >

> > >

> > >

> > >

> > >

> > >

> > >

> > > ---------------------------------

> > > Looking for last minute shopping deals? Find them fast with

>

> > Search.

> > >

> > >

[Guest guest]

Yes CML can cause vision problems. In fact, that's how some people

get diagnosed.

______________________

When you are on Gleevec, it can cause increased tearing in the eye and this

can cause blurry vision. Once your white blood count is under control, the

CML itself is not causing the eye problems, but they are drug related.

C.

[Guest guest]

This will be my 2nd week on Gleevek, so I believe it's the CML.

I'll see my eye Dr. soon to be sure.

Tahnks again

Cogan <ncogan@...> wrote:

Yes CML can cause vision problems. In fact, that's how some people

get diagnosed.

______________________

When you are on Gleevec, it can cause increased tearing in the eye and this

can cause blurry vision. Once your white blood count is under control, the

CML itself is not causing the eye problems, but they are drug related.

C.

---------------------------------

Never miss a thing. Make your homepage.

[Guest guest]

>

> Yes CML can cause vision problems. In fact, that's how some people

> get diagnosed.

> ______________________

> When you are on Gleevec, it can cause increased tearing in the eye

and this

> can cause blurry vision. Once your white blood count is under

control, the

> CML itself is not causing the eye problems, but they are drug related.

>

> C.

************************************************

Hi ,

I believe that is newly diagnosed so I don't know if CML can be

ruled out as causing her vision problems.

There's a very technical but informative article that illustrates the

various complications that leukemias (including CML) can cause in the

eyes where vision can be effected.

http://tinyurl.com/yvcjmu

Of course there are also many other reasons that someone could be

having vision problems so it's always a good idea to have it checked

out.

Tracey