Re: Can someone please help me with my FISH results

[Guest guest]

Hi Deloni,

I have no idea why they would have done this particular type of FISH

test on you. Either they suspected that you had another disease or

they just mixed up the test.

The good news is that you don't appear to have any of the diseases

that are related to these chromosomes (16 and 22) but the bad news is

that it tells you nothing about your CML.

In order to get an idea of what your CML is doing, they need to look

at the BCR/ABL rearrangement on chromosomes 9 and 22 which they

didn't do on this test.

I suggest you ask your doctor why this test was done and not the

usual FISH that looks for BCR/ABL.

Goodluck,

Tracey

>

> Hi,

> I am confused about my FISH results and was hoping some of the

great people on the board can help interpret the reults. They are as

follows: Interphase cells:200

> Peripheral Cells:0

> FISH results: Negative for 16q22 rearrangement by FISH nuc ish

(CBFBx2) (200) Interpretation and Comments:

> The FISH study showed no evidence of a CBFB (16q22) rearrangement,

inv(16) or t(16;16), seen in acute myelomonocytic leukemia with

eosinophilia, less commonly in other forms of acute myeloid leukemia,

and rarely myelodysplastic syndrome. A normal hybridization signal

was detected in more than 98% of onterphase cells analyzed. To be

considered positive, a " break apart " FISH pattern should be detected

in 3% or more cells. This test will not detect other cytogenetic

abnormalities that may have clinical significance. These reults

should be considered incomonation with other standard cytogenic

results as well as other clinical and hematological data.

> Here is why I am confused. What does 16 and 22 have to do with

this? I thought they were looking for 9 and 22? I think this is very

good news, but I am confused about the whole 16/22 thing. Someone

please help. Thanks,

> D

>

>

> ---------------------------------

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[Guest guest]

Hi Lori,

Is it just possible that the lab mistook the 9 22 test for a 16 22

test?

Zavie.

>

> Hi,

> I am confused about my FISH results and was hoping some of the

great people on the board can help interpret the reults. They are as

follows: Interphase cells:200

> Peripheral Cells:0

> FISH results: Negative for 16q22 rearrangement by FISH nuc ish

(CBFBx2) (200) Interpretation and Comments:

> The FISH study showed no evidence of a CBFB (16q22) rearrangement,

inv(16) or t(16;16), seen in acute myelomonocytic leukemia with

eosinophilia, less commonly in other forms of acute myeloid

leukemia, and rarely myelodysplastic syndrome. A normal

hybridization signal was detected in more than 98% of onterphase

cells analyzed. To be considered positive, a " break apart " FISH

pattern should be detected in 3% or more cells. This test will not

detect other cytogenetic abnormalities that may have clinical

significance. These reults should be considered incomonation with

other standard cytogenic results as well as other clinical and

hematological data.

> Here is why I am confused. What does 16 and 22 have to do with

this? I thought they were looking for 9 and 22? I think this is very

good news, but I am confused about the whole 16/22 thing. Someone

please help. Thanks,

> D

>

>

> ---------------------------------

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hottest shows on TV.

>

>

[Guest guest]

Zavie,

Thanks for the response. I found out they did in fact make an error on the

test. I found out from Shands that the lab messed up. Oh well. Hope I still

have a good result.

Thanks,

Dennis

________________________________

From: Zavie [mailto:zmiller@...]

Sent: Wednesday, October 03, 2007 12:00 AM

Subject: [ ] Re: Can someone please help me with my FISH results

Hi Lori,

Is it just possible that the lab mistook the 9 22 test for a 16 22

test?

Zavie.

>

> Hi,

> I am confused about my FISH results and was hoping some of the

great people on the board can help interpret the reults. They are as

follows: Interphase cells:200

> Peripheral Cells:0

> FISH results: Negative for 16q22 rearrangement by FISH nuc ish

(CBFBx2) (200) Interpretation and Comments:

> The FISH study showed no evidence of a CBFB (16q22) rearrangement,

inv(16) or t(16;16), seen in acute myelomonocytic leukemia with

eosinophilia, less commonly in other forms of acute myeloid

leukemia, and rarely myelodysplastic syndrome. A normal

hybridization signal was detected in more than 98% of onterphase

cells analyzed. To be considered positive, a " break apart " FISH

pattern should be detected in 3% or more cells. This test will not

detect other cytogenetic abnormalities that may have clinical

significance. These reults should be considered incomonation with

other standard cytogenic results as well as other clinical and

hematological data.

> Here is why I am confused. What does 16 and 22 have to do with

this? I thought they were looking for 9 and 22? I think this is very

good news, but I am confused about the whole 16/22 thing. Someone

please help. Thanks,

> D

>

>

> ---------------------------------

> Tonight's top picks. What will you watch tonight? Preview the

hottest shows on TV.

>

>