Guest guest Posted October 25, 2007 Report Share Posted October 25, 2007 Hi , It would really be helpful to know just how much his PCR went up. I'm sure you already know that PCR's do fluctuate and depending on the lab that did them, there can be a significant margin of error with them. I've seen my PCR's fluctuate almost a complete log at times and I know others who've had this experience as well. The other thing I want to point out is that I think you're being a little bit unrealistic in expecting to achieve a 3 log reduction so quickly. Your first goal should be that reaches CCR (where the 20 cells analyzed in a bone marrow biopsy are Philadelphia free). Once he gets to CCR, then you can look forward to the 3 log reduction. Many of us took several years to achieve a 3 log reduction so don't be discouraged if isn't there yet. What matters is that he remains stable and hopefully in time, you'll see the trend continue to drop. Let us know when you have the numbers, in the mean time, try to relax. If the doctor used the words " ever so slightly " that indicates to me that is stable and the PCR has fluctuated within the margin of error that you could expect with the test. Take care, Tracey > > > Hi all: > My husband, , has been on Sprycel now for almost 4 months. He feels great..hardly any side affects anymore. He just got his first PCR test done...we had our fingers crossed and were hoping the call from his doc would be " GREAT NEWS!!! You did it! You reached a 3-log reduction!! " > > Well, we dont have the " reports " yet, just the call from the onc...so we dont have any numbers to share. But all she said was " Well......your numbers actually went up ever so slightly. Let's give it another 3-4 months and run another PCR. " He is still scheduled for a Bone Marrow Biopsy in December. > > We have asked her to gather all reports so can drop by and pick up copies. > > I dont know if many of you remember, but was taken off Gleevec due to liver intolerance. At the point he was taken off, he hadnt had a PCR test done for about 4 months prior. And, the onc didnt think to do one at the point she took him off. We are all kicking ourselves for that oversight, cuz ultimately, we dont now just how well he was responding to Gleevec, since he went off of it with a rather " old " PCR test. > > All in all---PCR tests that go up slightly--how worrysome is this? Again, we will share the exact numbers when we get them. Are we wrong to feel like this PCR will be our baseline test for Sprycel, so until we look at the results of the next one (in another 3-4 months), we shouldnt think this or that? > > We really felt like this was the one - like would get to be on Zavie's list!!! When we saw Dr. Druker, he said to give it a year....though he felt would respond in less time since Sprycel is so much more powerful. Dr. Druker is the one that told us to give Sprycel a year, and if didnt reach a 3-log reduction in that time to start looking into bone marrow matches. > > Regards > Cervera > wife of Cervera, dgnsd 07/2006 - current age: 35 > Was on 400mg Gleevec daily, changed to Sprycel due to liver intolerance 07/2007. > Currently on 140mg Sprycel daily. > _________________________________________________________________ > Boo! Scare away worms, viruses and so much more! Try Windows Live OneCare! > http://onecare.live.com/standard/en-us/purchase/trial.aspx? s_cid=wl_hotmailnews > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 25, 2007 Report Share Posted October 25, 2007 O!!! YIPPEEE!!! Number 1111 in the Zero Club Zavie _____ From: [mailto: ] On Behalf Of Cervera Sent: October 24, 2007 8:09 PM Subject: [ ] PCR log INCREASE Hi all: My husband, , has been on Sprycel now for almost 4 months. He feels great..hardly any side affects anymore. He just got his first PCR test done...we had our fingers crossed and were hoping the call from his doc would be " GREAT NEWS!!! You did it! You reached a 3-log reduction!! " Well, we dont have the " reports " yet, just the call from the onc...so we dont have any numbers to share. But all she said was " Well......your numbers actually went up ever so slightly. Let's give it another 3-4 months and run another PCR. " He is still scheduled for a Bone Marrow Biopsy in December. We have asked her to gather all reports so can drop by and pick up copies. I dont know if many of you remember, but was taken off Gleevec due to liver intolerance. At the point he was taken off, he hadnt had a PCR test done for about 4 months prior. And, the onc didnt think to do one at the point she took him off. We are all kicking ourselves for that oversight, cuz ultimately, we dont now just how well he was responding to Gleevec, since he went off of it with a rather " old " PCR test. All in all---PCR tests that go up slightly--how worrysome is this? Again, we will share the exact numbers when we get them. Are we wrong to feel like this PCR will be our baseline test for Sprycel, so until we look at the results of the next one (in another 3-4 months), we shouldnt think this or that? We really felt like this was the one - like would get to be on Zavie's list!!! When we saw Dr. Druker, he said to give it a year....though he felt would respond in less time since Sprycel is so much more powerful. Dr. Druker is the one that told us to give Sprycel a year, and if didnt reach a 3-log reduction in that time to start looking into bone marrow matches. Regards Cervera wife of Cervera, dgnsd 07/2006 - current age: 35 Was on 400mg Gleevec daily, changed to Sprycel due to liver intolerance 07/2007. Currently on 140mg Sprycel daily. __________________________________________________________ Boo! Scare away worms, viruses and so much more! Try Windows Live OneCare! http://onecare. <http://onecare.live.com/standard/en-us/purchase/trial.aspx?s_cid=wl_hotmail news> live.com/standard/en-us/purchase/trial.aspx?s_cid=wl_hotmailnews Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 25, 2007 Report Share Posted October 25, 2007 Sorry Zavie-- I have a tendendancy to ramble and it seems I have confused you. I actually stated that we were WISHING the doctor said " Yeah--3-log reduction! " , but she DID NOT say that and in fact 's numbers slightly increased ever so slightly. I wish that we could take your #1111 in the Zero Club, but it will have to go to someone else! Hopefully will get his number soon! From: zmiller@...: @...: weez_555@...: RE: [ ] PCR log INCREASEDate: Wed, 24 Oct 2007 23:45:13 -0400 O!!! YIPPEEE!!! Number 1111 in the Zero Club Zavie From: [mailto: ] On Behalf Of CerveraSent: October 24, 2007 8:09 PM@...: [ ] PCR log INCREASE Hi all:My husband, , has been on Sprycel now for almost 4 months. He feels great..hardly any side affects anymore. He just got his first PCR test done...we had our fingers crossed and were hoping the call from his doc would be " GREAT NEWS!!! You did it! You reached a 3-log reduction!! " Well, we dont have the " reports " yet, just the call from the onc...so we dont have any numbers to share. But all she said was " Well......your numbers actually went up ever so slightly. Let's give it another 3-4 months and run another PCR. " He is still scheduled for a Bone Marrow Biopsy in December.We have asked her to gather all reports so can drop by and pick up copies.I dont know if many of you remember, but was taken off Gleevec due to liver intolerance. At the point he was taken off, he hadnt had a PCR test done for about 4 months prior. And, the onc didnt think to do one at the point she took him off. We are all kicking ourselves for that oversight, cuz ultimately, we dont now just how well he was responding to Gleevec, since he went off of it with a rather " old " PCR test. All in all---PCR tests that go up slightly--how worrysome is this? Again, we will share the exact numbers when we get them. Are we wrong to feel like this PCR will be our baseline test for Sprycel, so until we look at the results of the next one (in another 3-4 months), we shouldnt think this or that?We really felt like this was the one - like would get to be on Zavie's list!!! When we saw Dr. Druker, he said to give it a year....though he felt would respond in less time since Sprycel is so much more powerful. Dr. Druker is the one that told us to give Sprycel a year, and if didnt reach a 3-log reduction in that time to start looking into bone marrow matches.Regards Cerverawife of Cervera, dgnsd 07/2006 - current age: 35Was on 400mg Gleevec daily, changed to Sprycel due to liver intolerance 07/2007.Currently on 140mg Sprycel daily.__________________________________________________________Boo! Scare away worms, viruses and so much more! Try Windows Live OneCare!http://onecare.live.com/standard/en-us/purchase/trial.aspx?s_cid=wl_hotm\ ailnews Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 25, 2007 Report Share Posted October 25, 2007 Hi , Don’t be so quick to reject the Zero Club number. The criterion to get a number and join the club is for the patient to be at CCR. Not PCRU or a 3 log reduction. So does qualify and the number 1111 is assigned to . The next goal is for him to get to a 3 log reduction. Zavie _____ From: [mailto: ] On Behalf Of Cervera Sent: October 25, 2007 12:24 PM Zavie miller; Subject: RE: [ ] PCR log INCREASE Sorry Zavie-- I have a tendendancy to ramble and it seems I have confused you. I actually stated that we were WISHING the doctor said " Yeah--3-log reduction! " , but she DID NOT say that and in fact 's numbers slightly increased ever so slightly. I wish that we could take your #1111 in the Zero Club, but it will have to go to someone else! Hopefully will get his number soon! From: zmillersympatico (DOT) <mailto:zmiller%40sympatico.caTo> caTo: groups (DOT) <mailto:%40CC> comCC: weez_555hotmail (DOT) <mailto:weez_555%40hotmail.comSubject> comSubject: RE: [ ] PCR log INCREASEDate: Wed, 24 Oct 2007 23:45:13 -0400 O!!! YIPPEEE!!! Number 1111 in the Zero Club Zavie From: groups (DOT) <mailto:%40> com [mailto:groups (DOT) <mailto:%40> com] On Behalf Of CerveraSent: October 24, 2007 8:09 PMgroups (DOT) <mailto:%40Subject> comSubject: [ ] PCR log INCREASE Hi all:My husband, , has been on Sprycel now for almost 4 months. He feels great..hardly any side affects anymore. He just got his first PCR test done...we had our fingers crossed and were hoping the call from his doc would be " GREAT NEWS!!! You did it! You reached a 3-log reduction!! " Well, we dont have the " reports " yet, just the call from the onc...so we dont have any numbers to share. But all she said was " Well......your numbers actually went up ever so slightly. Let's give it another 3-4 months and run another PCR. " He is still scheduled for a Bone Marrow Biopsy in December.We have asked her to gather all reports so can drop by and pick up copies.I dont know if many of you remember, but was taken off Gleevec due to liver intolerance. At the point he was taken off, he hadnt had a PCR test done for about 4 months prior. And, the onc didnt think to do one at the point she took him off. We are all kicking ourselves for that oversight, cuz ultimately, we dont now just how well he was responding to Gleevec, since he went off of it with a rather " old " PCR test. All in all---PCR tests that go up slightly--how worrysome is this? Again, we will share the exact numbers when we get them. Are we wrong to feel like this PCR will be our baseline test for Sprycel, so until we look at the results of the next one (in another 3-4 months), we shouldnt think this or that?We really felt like this was the one - like would get to be on Zavie's list!!! When we saw Dr. Druker, he said to give it a year....though he felt would respond in less time since Sprycel is so much more powerful. Dr. Druker is the one that told us to give Sprycel a year, and if didnt reach a 3-log reduction in that time to start looking into bone marrow matches.Regards Cerverawife of Cervera, dgnsd 07/2006 - current age: 35Was on 400mg Gleevec daily, changed to Sprycel due to liver intolerance 07/2007.Currently on 140mg Sprycel daily.__________________________________________________________Boo! Scare away worms, viruses and so much more! Try Windows Live OneCare!http://onecare. <http://onecare.live.com/standard/en-us/purchase/trial.aspx?s_cid=wl_hotmail news> live.com/standard/en-us/purchase/trial.aspx?s_cid=wl_hotmailnews[Non-text portions of this message have been removed] __________________________________________________________ Help yourself to FREE treats served up daily at the Messenger Café. Stop by today. http://www.cafemess <http://www.cafemessenger.com/info/info_sweetstuff2.html?ocid=TXT_TAGLM_OctW Ltagline> enger.com/info/info_sweetstuff2.html?ocid=TXT_TAGLM_OctWLtagline Quote Link to comment Share on other sites More sharing options...
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