RE: Please interpret my FISH results

[Guest guest]

Congratulations Dennis, you are a big fat zero!!! The only time you'll

want to hear that I'm sure

I suspect that Zavie will be along momentarily to asign you a zero club

number.

Tracey

[Guest guest]

That means you are now in Complete Cytogenetic Remission (the CCR

acronym you see in a lot of posts). From now on you should have PCR

tests to monitor the residual cml. A FISH at 0 means that you are

probably at 2 log reduction or better, next goal is to get a 3 log (10

time less cml cells than at 2 log), or Major Molecular Remission

(MMR). But the important thing to remember is that the main cml study

shows that you have very good odds (better than 95% at 5 years) of

staying in remission.

Marcos.

On Feb 11, 2008 10:46 AM, Tracey <traceyincanada@...> wrote:

>

>

>

>

> Congratulations Dennis, you are a big fat zero!!! The only time you'll

> want to hear that I'm sure

>

> I suspect that Zavie will be along momentarily to asign you a zero club

> number.

>

> Tracey

>

>

--

Marcos Perreau Guimaraes

Suppes Brain Lab

Ventura Hall - CSLI

Stanford University

220 Panama street

Stanford CA 94305-4101

650 614 2305

650 630 5015 (cell)

marcospg@...

montereyunderwater@...

www.stanford.edu/~marcospg/

[Guest guest]

O!!! YIPPEEE!!!

Number 1149 in the Zero Club

Zavie

Zavie (age 69)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.2 log reduction Jun/07

3.6 log reduction Sep/07

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 309-296-0807

Cell: 613-202-0204

ID: zaviem

YM: zaviemiller

Skype: Zavie

_____

From: [mailto: ] On Behalf Of Dennis

Mc

Sent: February 11, 2008 1:48 PM

Subject: [ ] Please interpret my FISH results

Hello,

Thanks for your help. I have received my second FISH test results.

They are as follows:

FISH Results:

Negative for BCR/ABL, t (9;22), fusion by FISH

Nuc ish (ABL1, BCR)x2 (200)

Interpretation and Comments:

The FISh study showed no evidence of a BCR/ABL Philadelphia (9;22)

translocation.

A normal hybridization pattern (BCR/ABL1 dual fusion probe; Abbott

Molecular, INC/BYSIS, INC. ) was documented. The classical

translocation pattern reported in the September 2007 study was not

observed in this study. The BCR probe spans the common breakpoints of

both the major and minor BCR. If a low level of BCR/ABL positive cells

or minimal residue is suspected, analysis by RT-PCR should also be

considered. This test will not detect other abnormalities that may have

clinical significance.

Am I a ZERO?

Thanks for your reply (especially ZAVIE)

D