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Donna:

I have had CML now for 10 years this March and as you can see, I was

diagnosed in the years before Gleevec when Interferon was the best thing

available. I, too, am a patient at MDA, though in the last three years I

have only sent my tests, rather than going to Houston.

I have been PCRU since January 2002. Though my doctors no longer pressure

me to have frequent BMBs, for several years I had them every quarter at MDA.

They have the best people doing them, and I have only once had a BMB there

that was painful. I have never had any mutations.

Even now I ask for a BMB once a year and am finally considering having one

every other year. It gives me peace of mind, which I cannot get any other

way.

I urge you to follow your MDA doctors' lead in these matters. They are the

experts and treat a multitude of patients with our problems.

This is just meant as food for thought.

Margot

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Donna:

I have been traveling today and did

not get yhour message till late. I too

was a patient at MDACC and ended up

leaving because I had a difficult

time communicating with medical

Team [ ] Donna

-Dear Friends,

Thanks for all your input I am in a panic now to say the least :)

My Onc at Pensacola had advised me that the " standard of care " was to

be tested every year and he thot that Cortes was wanting to test me

every 3 mos as part of a clinical trial. Which is all well and good

but I am 10 hrs from Houston and have 4 children and that trip is not

much fun. What I am really confused about is why Cortes never really

made a suggestion for my course of treatment after he received the

results of tests at MD , I only got a fumbled comment from

the Pensacola Onc that he presumed Cortes had put my weird

mutations " on the shelf " and to carry on with the standard of care

course.

Looking back over my results a Ault (DR> Cortes) side kick notes

in them that the mutations are due to clonal evolution and can be

kept in check with medication.

Anyway after considering your sound advice (which I value far more

than the Pen Onc (who incidentally has now resigned???)

I am going back to my newly assigned Onc in Pensacola next friday and

ask him what my course of action should be. I will also e=mail

Cortes and ask him what he thinks. Don't ask me why I havent worried

about all this til yesterday Call me an Ostrich.

One question though. If it is possible to start going into blast

phase in the short span of 2 weeks why dont we have our cbc's checked

more often. I reached CCR so am only monitored every 3 mos. It

scares me to think everything can go wrong so quickly.

I am so grateful to you all.

Regards Donna x-- In , " marri35 " <tmtip@...>

wrote:

>

> I totally agree... I think your cents are worth so much more... By

> pure necessity sometimes we 'figure' things out! Just imagine if

> everyone were put on those much smaller doses... GET me a

> calculator.. that wouldn't be in the drug company's best interest I

> suspect. Just a thought... maybe I'm way off base. I have " self

> adjusted " my doses of Sprycel..unfortunately... had great

difficulty

> finding decent care etc. and had horrible side effects. STill

early.

> Trying to get into CML guru eventually (no ins).

>

>

> >

> > Hey Group. . .

> > I have said this before and I will say it again. . .

> > " We are a Statistic to the Hematologist/Oncologist; but each

one

> of us is an Individual in our Survival and the choice(s) we make on

> our treatment is the most important decision we will make during

our

> lifetime " .

> > Due to 'side effects', I was unable to tolerate 400 or 600 m.g.

> of our gold on a daily basis; therefore, my daily dosage was 300

m.g.

> After reaching 0.00136 in 1/2005; I began to 'pulse'.

> > My reasoning was 'if it took 300 m.g. to reach '0'; I didn't

need

> that dosage daily to maintain my response'. My RT-PCR Test was

> 0.00021 on February 13th and I take 300 m.g.~~3 - 4 days a week and

> my side effects are greatly diminished from the H**L I went through

> after diagnosis.

> > " I am not a Doctor, never portrayed one on TV; nor do I aspire

to

> be a Physician in another life " . This is FYI~~my 2 cents only.

> > Take care, as always I have ALL in my prayers. . . " K "

> >

> >

> >

> > " K "

> > " I AIN'T FINISHED YET " !!!

> >

> >

> >

> >

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