G250E Mutation and Goodbye Gleevec!

[Guest guest]

Dear Group:

I have had CML for five years and have recently developed the G250E

mutation which, I understand, is sensitive to both dasatinib and nilotinib. I

am now on 800 mg. of imatinib but PCR has gradually risen over the past months

from neglible to .5% PCR from the bone marrow and .3% PCR from peripheral blood.

FISH is 0/500 down from 2/500 about a month ago. Cytogenetics are pending.

My doc at MSKCC, who is considering switching me to dasatinib says the

response data for patients for both these drugs is rather sparse.

Does anyone have info. or data on the G250E mutation and which drug is

most effective? I looks as if Gleevec and I will be getting a divorce.

Many thanks,

Carl Davies

town, PA, USA

---------------------------------

Looking for last minute shopping deals? Find them fast with Search.