RE: Questions/1 Year Anniversary - Help!!!

[Guest guest]

Your oncologist is right. From what I understand from your post 4.1325

is the baseline ratio of the lab which is an average result at dx for

previous patients. Same thing for me at the Stanford hospital lab. The

formula for the log reduction is correct :

log reduction = log10(baseline/ measured ratio) = log10(baseline) -

log10(measured ratio), where the measured ratio is what you write

BCR-ABL;ABL ratio. It looks to me that the 1.723 is the log reduction.

If it was the the ratio the log reduction would be in that case about

0.38 , what sounds unlikely (I dunno how you got 2.4095). So my guess

1.723 is the log reduction, what means the number of cml cells are

about 55 times lower than the average patient at dx. It's close to CCR

and it makes more sense at one year of treatment. As your dr not

understanding the results I am not so surprised. You may want to call

or pay a visit to the quest lab to be sure that 1.723 is the log

reduction. Also you may want to see a cml specialist, as it is

important to know if you are at CCR at one year. The dosage of gleevec

depends on that information.

Marcos.

On Jan 26, 2008 9:30 PM, manny45409 <manny1113@...> wrote:

>

>

>

>

> I recently just came up on a year with CML and had a PCR test done.

> I need help with a few things, as my doctor even admitted he did not

> understand my latest results. Let me first start off by saying that

> I never had a bone marrow test at diagnosis. Therefore, I have no

> baseline. However, my oncologist indicates I did not need one. My

> latest PCR test came back with BCR-ABL T (9;22) Fusion result at

> 0.078 H. It also indicates that my BCR-ABL:ABL Ratio result is 1.723

> (next to that it indicates that this is my log reduction). My doctor

> and I are puzzled, as my CBC's have been great all year. The PCR

> test was done at Quest Diagnositics. It indicates to calculate the

> log reduction, you should do the following: Log10(4.1325) - Log10

> (BCR-ABL;ABL ration) Unit/log reduct. Given this information, is my

> log reduction 2.4095 or is it a 1.723 log reduction (page 1 of my

> report)? I am concerned about my numbers, as I know that in order to

> reduce the risk of disease progression one must achieve a 3-log

> reduction during the first year of treatment. Should I consider

> taking Sprycel? I'm even considering a transplant since I am only 31

> (thinking that should of been my first choice but there are so many

> risk factors involved). I appreciate any responses to my post, as I

> am confused and scared. I want to live a long productive life, as I

> have two kids and a wife that I love dearly. By the way, I started

> on Gleevec 400mg in January 07 and switched to Gleevec 600mg in

> March. I'm not sure if switching to 800mg would help at all given

> all the literature that exist.

>

>

--

Marcos Perreau Guimaraes

Suppes Brain Lab

Ventura Hall - CSLI

Stanford University

220 Panama street

Stanford CA 94305-4101

650 614 2305

650 630 5015 (cell)

marcospg@...

montereyunderwater@...

www.stanford.edu/~marcospg/

[Guest guest]

Sounds like my own story except that I started on 600 mg and when I didn't

reach 3 logs at one year, they moved me to 800 mg and within 2 months I was

there, I was told that the one year mark isn't being and strict of time

anymore. They told me they have extended it to 18 months as the stats don't

show

any difference in the outcomes. I have been over a 3 log reduction since.

The experts on this site will give you the good suggestions but I just

wanted to throw out my 2 cents there.

I was only 33 when diagnosed as well. (35 now). I also have 3 little

children as well. Do you have a sibling match? Transplant is such an

individual

choice. I am now on Spyrcel and feeling great. Much better quality of life

then Gleevec. I had some tremendous side effects with that.

Best of luck and I am sure you will get some great advice from others.

35

CML 5/13/05

Gleevec 800mg until 8/07

Spyrcel 100 mg since 9/7/07

Wife and mother of 3 (12,8,7)

**************Biggest Grammy Award surprises of all time on AOL Music.

(http://music.aol.com/grammys/pictures/never-won-a-grammy?NCID=aolcmp00300000002\

5

48)

[Guest guest]

,

Thanks for the advice. I appreciated it. I am going to have two of my siblings

tested just in case.

Manny

@...: vegasrnjen@...: Sun, 27 Jan 2008 09:45:44

-0500Subject: Re: [ ] Questions/1 Year Anniversary - Help!!!

Sounds like my own story except that I started on 600 mg and when I didn't reach

3 logs at one year, they moved me to 800 mg and within 2 months I was there, I

was told that the one year mark isn't being and strict of time anymore. They

told me they have extended it to 18 months as the stats don't show any

difference in the outcomes. I have been over a 3 log reduction since.The experts

on this site will give you the good suggestions but I just wanted to throw out

my 2 cents there. I was only 33 when diagnosed as well. (35 now). I also have 3

little children as well. Do you have a sibling match? Transplant is such an

individual choice. I am now on Spyrcel and feeling great. Much better quality of

life then Gleevec. I had some tremendous side effects with that.Best of luck and

I am sure you will get some great advice from others. 35CML

5/13/05Gleevec 800mg until 8/07Spyrcel 100 mg since 9/7/07Wife and mother of 3

(12,8,7)**************Biggest Grammy Award surprises of all time on AOL Music.

(http://music.aol.com/grammys/pictures/never-won-a-grammy?NCID=aolcmp00300000002\

548)