RE: Stomaching Sprycel (cross-posted)

[Guest guest]

Hello Carl,

I, too, had stomach problems while taking 800 mg/day of Gleevec and had two

stomach bleeds, inflamation of the rest of my stomach and took Protonix for

awhile which cleared that up. I now have been on Sprycel for about 1 1/2 years.

I was taken off Sprycel for about 2 1/2 weeks recently because of pleural

effusion and peripheral neuropathy and started taking it again about a week ago.

I take my two 50 mg tabs in the morning was a serving of Enusre or another

nutritional drink and have not had any stomach problems at all.

L

[ ] " Stomaching " Sprycel (cross-posted)

Greetings:

As you may know because of the G250E mutation I have to switch from Gleevec to

Sprycel.

While on Gleevec, I had to take it with food and even then I experienced

nausea and occasional vomiting.

What is the best way to take Sprycel? With water? With food? And when is the

best time of day?

Is it as rough on the stomach as Gleevec?

I would appreciate feedback from you Sprycel veterans and some ideas as to

what initial side effects to expect.

Many thanks,

Carl

---------------------------------

Never miss a thing. Make your homepage.

[Guest guest]

I was on Sprycel for three years.. I could take it any time. No food, food,

whatever. It never bothered my stomach. Unfortunately after three years just

two weeks ago I developed some bad side effects. Even tho I am PCRU. It

worked that way. My Doctor is going to start me on Tsigna. Anyone out there

on Tsigna? What side effects are you having and what dosage are you on? I am

really sad about having to go of Sprycel.

Sharon

_____

From: [mailto: ] On Behalf Of Carl

Davies

Sent: Friday, February 22, 2008 9:10 AM

CMLHopegooglegroups; asiancmlsupportgroup ;

Subject: [ ] " Stomaching " Sprycel (cross-posted)

Greetings:

As you may know because of the G250E mutation I have to switch from Gleevec

to Sprycel.

While on Gleevec, I had to take it with food and even then I experienced

nausea and occasional vomiting.

What is the best way to take Sprycel? With water? With food? And when is the

best time of day?

Is it as rough on the stomach as Gleevec?

I would appreciate feedback from you Sprycel veterans and some ideas as to

what initial side effects to expect.

Many thanks,

Carl

---------------------------------

Never miss a thing. Make your homepage.

[Guest guest]

See I do not understand why some doctors just take you off Sprycell for

awhile for pleural effusion and then back. My dr. just insists I go off it

and on to Tsigna. I wonder sometimes who knows what. By the way

---when you had pleural effusion what did they do about it? Did they

draw out the fluid. You can email me at onthewtr@... if you like.

I am in the midst of deciding what to do.

Sharon

_____

From: [mailto: ] On Behalf Of

seloew12

Sent: Friday, February 22, 2008 9:30 AM

Subject: Re: [ ] " Stomaching " Sprycel (cross-posted)

Hello Carl,

I, too, had stomach problems while taking 800 mg/day of Gleevec and had two

stomach bleeds, inflamation of the rest of my stomach and took Protonix for

awhile which cleared that up. I now have been on Sprycel for about 1 1/2

years. I was taken off Sprycel for about 2 1/2 weeks recently because of

pleural effusion and peripheral neuropathy and started taking it again about

a week ago. I take my two 50 mg tabs in the morning was a serving of Enusre

or another nutritional drink and have not had any stomach problems at all.

L

[ ] " Stomaching " Sprycel (cross-posted)

Greetings:

As you may know because of the G250E mutation I have to switch from Gleevec

to Sprycel.

While on Gleevec, I had to take it with food and even then I experienced

nausea and occasional vomiting.

What is the best way to take Sprycel? With water? With food? And when is the

best time of day?

Is it as rough on the stomach as Gleevec?

I would appreciate feedback from you Sprycel veterans and some ideas as to

what initial side effects to expect.

Many thanks,

Carl

---------------------------------

Never miss a thing. Make your homepage.

[Guest guest]

Hi Sharon,

I'm on a Sprycel trial so of course they want to continue and I would like to

continue on Sprycel as well if I can handle it ie., no pleural effusion or

peripheral neuropathy. But another doc I know from NIH research strongly

suggested I move on to Tasigna, too. I'm also weighing my options and waiting

to see how I do on this second try with Sprycel. You know, some people also

take vacations with Gleevec and I eventually was not responsive to that drug. I

was fortunate to get into a Sprycel trial.

Lots of things to consider.

Let me know whwhat you decide to do and why, if you want.

L.

[ ] " Stomaching " Sprycel (cross-posted)

Greetings:

As you may know because of the G250E mutation I have to switch from Gleevec

to Sprycel.

While on Gleevec, I had to take it with food and even then I experienced

nausea and occasional vomiting.

What is the best way to take Sprycel? With water? With food? And when is the

best time of day?

Is it as rough on the stomach as Gleevec?

I would appreciate feedback from you Sprycel veterans and some ideas as to

what initial side effects to expect.

Many thanks,

Carl

---------------------------------

Never miss a thing. Make your homepage.

[Guest guest]

Hi again,

I too, was PCRU and was doing quite well. I really don't know the answer. I

asked my trial onc about Tasigna and we do have it on the table for discussion.

I would not hesitate to demand it if these bad side effects came back.

L.

[ ] " Stomaching " Sprycel (cross-posted)

Greetings:

As you may know because of the G250E mutation I have to switch from Gleevec

to Sprycel.

While on Gleevec, I had to take it with food and even then I experienced

nausea and occasional vomiting.

What is the best way to take Sprycel? With water? With food? And when is the

best time of day?

Is it as rough on the stomach as Gleevec?

I would appreciate feedback from you Sprycel veterans and some ideas as to

what initial side effects to expect.

Many thanks,

Carl

---------------------------------

Never miss a thing. Make your homepage.

[Guest guest]

Carl, I have been on Sprycel since 6/07 and I take one before breakfast and one

before dinner with no problems. My experience has been alot better with the

Sprycel than Gleevec. Best of Luck.

Mike

Carl Davies <ctdavies2003@...> wrote:

Greetings:

As you may know because of the G250E mutation I have to switch from Gleevec to

Sprycel.

While on Gleevec, I had to take it with food and even then I experienced nausea

and occasional vomiting.

What is the best way to take Sprycel? With water? With food? And when is the

best time of day?

Is it as rough on the stomach as Gleevec?

I would appreciate feedback from you Sprycel veterans and some ideas as to what

initial side effects to expect.

Many thanks,

Carl

---------------------------------

Never miss a thing. Make your homepage.

[Guest guest]

I was on a study also but they have taken me off it because of the plural

effusion. Did you tell me you had plural effusion also? If so what did they

do for you. Did they draw the liquid out?

Anyone one have an ans to that question? What do they do. Does it just go

away.

Sharon T

_____

From: [mailto: ] On Behalf Of

seloew12

Sent: Friday, February 22, 2008 9:49 AM

Subject: Re: [ ] " Stomaching " Sprycel (cross-posted)

Hi Sharon,

I'm on a Sprycel trial so of course they want to continue and I would like

to continue on Sprycel as well if I can handle it ie., no pleural effusion

or peripheral neuropathy. But another doc I know from NIH research strongly

suggested I move on to Tasigna, too. I'm also weighing my options and

waiting to see how I do on this second try with Sprycel. You know, some

people also take vacations with Gleevec and I eventually was not responsive

to that drug. I was fortunate to get into a Sprycel trial.

Lots of things to consider.

Let me know whwhat you decide to do and why, if you want.

L.

[ ] " Stomaching " Sprycel (cross-posted)

Greetings:

As you may know because of the G250E mutation I have to switch from Gleevec

to Sprycel.

While on Gleevec, I had to take it with food and even then I experienced

nausea and occasional vomiting.

What is the best way to take Sprycel? With water? With food? And when is the

best time of day?

Is it as rough on the stomach as Gleevec?

I would appreciate feedback from you Sprycel veterans and some ideas as to

what initial side effects to expect.

Many thanks,

Carl

---------------------------------

Never miss a thing. Make your homepage.

[Guest guest]

Sharon,

My pleural effusion was not horrible but I also had peripheral neuropathy in

all ten finger tips and could not write or type -- and I'm a writer. So, the

level of the liquid in my lungs was possibly less than what you have or had. I

did take lasix and potassium for one week at the beginning of being off the

trial then nothing after that. That did help but it took the full 2 1/2 weeks

to get it out of my system.

Now I'm monitoring myself and was told that if I got the least bit of pleural

effusion or had trouble breathing to call them immediately. My trial onc is in

land and I live in Virginia so it take more than an hour to get to the trial

onc and if I'm disabled in any way it wouldn't be possible for me to drive all

that way. They did not draw any loiquid out of my lungs.

L.

[ ] " Stomaching " Sprycel (cross-posted)

Greetings:

As you may know because of the G250E mutation I have to switch from Gleevec

to Sprycel.

While on Gleevec, I had to take it with food and even then I experienced

nausea and occasional vomiting.

What is the best way to take Sprycel? With water? With food? And when is the

best time of day?

Is it as rough on the stomach as Gleevec?

I would appreciate feedback from you Sprycel veterans and some ideas as to

what initial side effects to expect.

Many thanks,

Carl

---------------------------------

Never miss a thing. Make your homepage.

[Guest guest]

Carl,

I have only been on Sprycel for three months.? It doesn't seem to matter if?I

take it with food or not.? Since I am on the trial and I must take it twice a

day, I take it with food in the morning and just before bed at night without

food.

?

For only a week of the three months I felt nausea at night.? The docs said to

take with lots of water and to sit up for awhile after you take it to make sure

it 'goes all the way down.'?? I felt worse when I took it with lots of water.?

Now I take it with just a couple of sips.? However, I do try to sit up for 15 to

30 minutes before lying down.

?

After the first month on the drug (and my first month with CML) I did need to

stop the drug because of low counts and pneumonia.? I didn't get the plueral

effusion but my clinic was watching very close for such things.? In three weeks

I had three or four chest xrays!

?

Since I never took Gleevec, I can't compare the two drugs.? I can say from what

I've heard, Tasigna seems to have some impact on heart rhythms, I may steer

clear of that since I have a murmur and palpitations from time to time already.?

?

For me, the major side effects on Sprycel have been the fevers and fatigue,

swelling feet and hands, some very minor neuropathy in my hands, and a funky eye

rash swelling thing.? However, this is probably due to the fact that I started

my CML treatment on Sprycel, and so I had a sizeable disease load to kill.?

?

Keep us posted on how you are doing.? At this moment, and for most of this

week.... I'm great!? Go Sprycel!

?

Happy Friday.

Rhonda

Re: [ ] " Stomaching " Sprycel (cross-posted)

Carl, I have been on Sprycel since 6/07 and I take one before breakfast and one

before dinner with no problems. My experience has been alot better with the

Sprycel than Gleevec. Best of Luck.

Mike

Carl Davies ctdavies2003@...> wrote:

Greetings:

As you may know because of the G250E mutation I have to switch from Gleevec to

Sprycel.

While on Gleevec, I had to take it with food and even then I experienced nausea

and occasional vomiting.

What is the best way to take Sprycel? With water? With food? And when is the

best time of day?

Is it as rough on the stomach as Gleevec?

I would appreciate feedback from you Sprycel veterans and some ideas as to what

initial side effects to expect.

Many thanks,

Carl

---------------------------------

Never miss a thing. Make your homepage.

[Guest guest]

Sharon,

I had a pleural effusion due to fractured ribs. It wasn't a bad effusion, so

they just waited it out. I did not stop my Gleevec. The only time that I did

stop, is when I had pneumonia, with a HCT of about 8.2, very low soduium, and

was in ICU for 5 days. I was also on Interferon and Neupogen at the same time.

@...: onthewtr@...: Fri, 22 Feb 2008

09:36:07 -0800Subject: RE: [ ] " Stomaching " Sprycel (cross-posted)

See I do not understand why some doctors just take you off Sprycell forawhile

for pleural effusion and then back. My dr. just insists I go off itand on to

Tsigna. I wonder sometimes who knows what. By the way---when you had

pleural effusion what did they do about it? Did theydraw out the fluid. You can

email me at onthewtr@... if you like.I am in the midst of deciding what

to do. Sharon_____ From: [mailto: ] On

Behalf Ofseloew12Sent: Friday, February 22, 2008 9:30 AMTo:

@...: Re: [ ] " Stomaching " Sprycel

(cross-posted)Hello Carl,I, too, had stomach problems while taking 800 mg/day of

Gleevec and had twostomach bleeds, inflamation of the rest of my stomach and

took Protonix forawhile which cleared that up. I now have been on Sprycel for

about 1 1/2years. I was taken off Sprycel for about 2 1/2 weeks recently because

ofpleural effusion and peripheral neuropathy and started taking it again abouta

week ago. I take my two 50 mg tabs in the morning was a serving of Enusreor

another nutritional drink and have not had any stomach problems at all.

L [ ] " Stomaching " Sprycel (cross-posted)Greetings:As

you may know because of the G250E mutation I have to switch from Gleevecto

Sprycel.While on Gleevec, I had to take it with food and even then I

experiencednausea and occasional vomiting. What is the best way to take Sprycel?

With water? With food? And when is thebest time of day?Is it as rough on the

stomach as Gleevec?I would appreciate feedback from you Sprycel veterans and

some ideas as towhat initial side effects to expect.Many

thanks,Carl---------------------------------Never miss a thing. Make your

homepage.

[Guest guest]

Wow, . I presume you're doing well now? Certainly hope so after reading

your endurance record.

L

[ ] " Stomaching " Sprycel (cross-posted)Greetings:As

you may know because of the G250E mutation I have to switch from Gleevecto

Sprycel.While on Gleevec, I had to take it with food and even then I

experiencednausea and occasional vomiting. What is the best way to take Sprycel?

With water? With food? And when is thebest time of day?Is it as rough on the

stomach as Gleevec?I would appreciate feedback from you Sprycel veterans and

some ideas as towhat initial side effects to expect.Many

thanks,Carl---------------------------------Never miss a thing. Make your

homepage.

[Guest guest]

Thanks ,

I did not even know I had fluid on my lung. Had no symptoms. They took a

chest xray to see what was going on because I was running fever. I asked

them if I could take a water pill and they said that was for congestive

heart failure not for pleural effusion. I do no want to have them draw it

out.

Sharon

_____

From: [mailto: ] On Behalf Of

seloew12

Sent: Friday, February 22, 2008 2:47 PM

Subject: Re: [ ] " Stomaching " Sprycel (cross-posted)

Sharon,

My pleural effusion was not horrible but I also had peripheral neuropathy in

all ten finger tips and could not write or type -- and I'm a writer. So, the

level of the liquid in my lungs was possibly less than what you have or had.

I did take lasix and potassium for one week at the beginning of being off

the trial then nothing after that. That did help but it took the full 2 1/2

weeks to get it out of my system.

Now I'm monitoring myself and was told that if I got the least bit of

pleural effusion or had trouble breathing to call them immediately. My trial

onc is in land and I live in Virginia so it take more than an hour to

get to the trial onc and if I'm disabled in any way it wouldn't be possible

for me to drive all that way. They did not draw any loiquid out of my lungs.

L.

[ ] " Stomaching " Sprycel (cross-posted)

Greetings:

As you may know because of the G250E mutation I have to switch from Gleevec

to Sprycel.

While on Gleevec, I had to take it with food and even then I experienced

nausea and occasional vomiting.

What is the best way to take Sprycel? With water? With food? And when is the

best time of day?

Is it as rough on the stomach as Gleevec?

I would appreciate feedback from you Sprycel veterans and some ideas as to

what initial side effects to expect.

Many thanks,

Carl

---------------------------------

Never miss a thing. Make your homepage.