Re: paper on long term effects on imatinib bone health

[Guest guest]

Thanks for that article Marcos, that was very informative in deed! I

only had one bone density test which showed that I was at the very

early stages of osteopenia but I'm sure my dietary habits have more

to do with that than the Gleevec. I've never drank milk or eaten

many calcium rich foods....ever. I'll welcome any increased bone

density that Gleevec can give me

Tracey

>

> Hi all,

> The journal blood has an article in the last issue on the long term

> effects of gleevec on bone formation. From what I read and was able

to

> understand (I am no md) gleevec has definitively an impact on our

> bones, but it may not be the way we usually thought. It looks it may

> actually increase bone density, they even suggest it could be used

to

> treat osteoporosis. They do encourage drs treating cml patients to

> monitor bone health. Here an extract from the conclusion :

> " In summary, we demonstrate for the first time that imatinib

mesylate

> significantly modulates bone turnover, as evidenced by an increase

in

> TBV and lowered levels of serum calcium and phosphate. Although we

are

> unable to predict the long-term skeletal consequences of this drug,

> our study does suggest that patient management and care should

include

> appropriate monitoring of skeletal health. Furthermore, the observed

> increase in TBV, a significant determinant of bone strength, raises

> the intriguing possibility that imatinib and similar agents may have

> uses in treating diseases that are characterized by generalized bone

> loss, such as osteoporosis and osteomalacia. This possibility is

> particularly attractive in light of the long-term safety data that

> have accrued during imatinib's widespread use as a front-line

therapy

> for CML and GIST. "

>

> The link is :

>

http://bloodjournal.hematologylibrary.org/cgi/content/full/111/5/2538

> Marcos.

> PS: No snow here, forecast for tomorrow is sun and temperature in

the 70s

>

> --

> Marcos Perreau Guimaraes

> Suppes Brain Lab

> Ventura Hall - CSLI

> Stanford University

> 220 Panama street

> Stanford CA 94305-4101

> 650 614 2305

> 650 630 5015 (cell)

> marcospg@...

> montereyunderwater@...

> www.stanford.edu/~marcospg/

>

[Guest guest]

Bone health is something I pay some attention because of the diving.

Bone problems (necrosis, osteoporosis) are frequent in people who dove

a long time, or deep with mixed gases, so I am pretty glad gleevec may

not be making things worse. Exercise is also a good way to keep strong

bones. I am no milk lover either but I compensate with cheese. BTW I

broke bones (fingers) a couple of time since dx (nothing to do with

the cml or gleevec, that's just the usual diving or climbing) and it

healed really well.

Marcos.

On Sun, Mar 9, 2008 at 12:51 PM, Tracey <traceyincanada@...> wrote:

>

>

>

>

> Thanks for that article Marcos, that was very informative in deed! I

> only had one bone density test which showed that I was at the very

> early stages of osteopenia but I'm sure my dietary habits have more

> to do with that than the Gleevec. I've never drank milk or eaten

> many calcium rich foods....ever. I'll welcome any increased bone

> density that Gleevec can give me

>

> Tracey

>

>

> >

> > Hi all,

> > The journal blood has an article in the last issue on the long term

> > effects of gleevec on bone formation. From what I read and was able

> to

> > understand (I am no md) gleevec has definitively an impact on our

> > bones, but it may not be the way we usually thought. It looks it may

> > actually increase bone density, they even suggest it could be used

> to

> > treat osteoporosis. They do encourage drs treating cml patients to

> > monitor bone health. Here an extract from the conclusion :

> > " In summary, we demonstrate for the first time that imatinib

> mesylate

> > significantly modulates bone turnover, as evidenced by an increase

> in

> > TBV and lowered levels of serum calcium and phosphate. Although we

> are

> > unable to predict the long-term skeletal consequences of this drug,

> > our study does suggest that patient management and care should

> include

> > appropriate monitoring of skeletal health. Furthermore, the observed

> > increase in TBV, a significant determinant of bone strength, raises

> > the intriguing possibility that imatinib and similar agents may have

> > uses in treating diseases that are characterized by generalized bone

> > loss, such as osteoporosis and osteomalacia. This possibility is

> > particularly attractive in light of the long-term safety data that

> > have accrued during imatinib's widespread use as a front-line

> therapy

> > for CML and GIST. "

> >

> > The link is :

> >

> http://bloodjournal.hematologylibrary.org/cgi/content/full/111/5/2538

> > Marcos.

> > PS: No snow here, forecast for tomorrow is sun and temperature in

> the 70s

> >

> > --

> > Marcos Perreau Guimaraes

> > Suppes Brain Lab

> > Ventura Hall - CSLI

> > Stanford University

> > 220 Panama street

> > Stanford CA 94305-4101

> > 650 614 2305

> > 650 630 5015 (cell)

> > marcospg@...

> > montereyunderwater@...

> > www.stanford.edu/~marcospg/

> >

>

>

>

>

--

Marcos Perreau Guimaraes

Suppes Brain Lab

Ventura Hall - CSLI

Stanford University

220 Panama street

Stanford CA 94305-4101

650 614 2305

650 630 5015 (cell)

marcospg@...

montereyunderwater@...

www.stanford.edu/~marcospg/