Re: Deletion on Chromosome 9

[Guest guest]

Hi Rhonda,

I found one abstract from the ASH meeting this year (ASH is the

American Society of Hematology and they meet once a year to discuss

all the latest and greatest information, all the top doctors from

around the world go to this conference).

Anyway, the abstract I found referred to patients who had deletion of

chromosome 9 and were on Gleevec. It showed that the deletion had

absolutely no effect on the patient's prognosis for either their

response or their loss of response.

I know you're on Sprycel but if this deletion has no effect for

people on Gleevec, we can be hopeful that it will have no effect for

people on Sprycel as well.

http://www.abstracts2view.com/hem07/view.php?nu=HEM07L1_648 & terms=

Tracey

>

> Hello CMLers...

>

>

> Just checking to see if any of you know if you additional deletions

on chromosome 9.

>

>

> ?

>

>

> Sometimes it's called (der)9 chromosome deletion, or homozygous

deletion on chromosome 9.

>

>

> ?

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>

> Also, anyone else heard of 'deletion of the tumor suppression gene

p16'?

>

>

> ?

>

>

> Ya'll are a wealth of wisdom on everything, so I bow to you....

>

>

> ?

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> Please let me know what you have experienced on the subject.

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> ?

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> Thanks so very much,

>

>

> Rhonda

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>

> dx Nov 2, 2007

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>

>

>

[Guest guest]

Hi Aliza,

In people with " garden variety CML " , there is a gene on chromosomes 9

and 22 that switch places to create the famous Philadelphia Chromosome.

Some people have additional chromosomal problems though and der 9 is

just one example of another abnormality that can sometimes occur.

Tracey

>

> what is delition?new to all the cml lingo

> aliza yaffa

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> **************It's Tax Time! Get tips, forms, and advice on AOL Money

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[Guest guest]

Hi Rhonda,

I saw a few articles that showed a poor prognosis as well but then I

realized that they were all pre Gleevec days. Things have changed so

dramatically in the last few years.

Tracey

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> >

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> > what is delition?new to all the cml lingo

>

> > aliza yaffa

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> >

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> >

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> >

>

> > **************It's Tax Time! Get tips, forms, and advice on AOL

Money

>

> &

>

> > Finance. (http://money.aol.com/tax?NCID=aolprf00030000000001)

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