PK level testing

[Guest guest]

Dear Jan,

Here is a site you can read about PK testing. You would have to ask your

oncologist if they do the testing, or send it off. I think it is the most

efficient way to determine if you are getting the right dose and I personally

believe everyone should get it as part of the protocol. How many do it, I really

don't know. A good topic for research.

" Two key reasons why drugs fail at late stages are a lack of understanding of

the relationship between dose-concentration response and unanticipated safety

events. Given this scenario, it is critical to have enabling tools that help

predict how a drug will perform in vivo and assist in the success of a clinical

therapeutic candidate.

Traditional PK/PD modeling in drug development defines parameters such as drug

dose concentration, drug exposure effects, drug half-life, drug concentrations

against time, and drug effects against time.

A variety of PK/PD modeling tools are available to drug development researchers,

and one of these is Pharsight's WinNonlin. " WinNonlin effectively performs PK/PD

modeling based on data such as the presence of drug in plasma at particular

points in time, and allows for calculation and estimation of critical PK

parameters such as maximum concentration, total exposure (i.e., area under the

curve), half-life, clearance rate, and volume of distribution. "

I have given you the website so that you can read the entire article, the

above is a synopsis.

http://www.dddmag.com/modeling-success-in-pk-pd-testing.aspx

Killing leukemia stem cells you sleep.

http://www.medicalnewstoday.com/articles/84420.php

Clinical Trials

http://www.clinicaltrials.gov/ct2/show/NCT00471497?term=cml & rank=11

Study of P210-B3A2 Derived Peptide Vaccine (2007)

Diagnosis of CML with b3a2 breakpoint http://tinyurl.com/2jksuc

Blessings,

Lottie